Inhibitors of the lipoxygenase arachidonic acid pathway impair glycocholate efflux in isolated rat hepatocytes

1991 ◽  
Vol 12 (3) ◽  
pp. 302-311 ◽  
Author(s):  
Jorge Quiroga ◽  
JoséL. Rodríguez-Sanromán ◽  
Francisco Guarner ◽  
Carlos Rodríguez Ortigosa ◽  
JoséM. Aréjola ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Rat Hepatocytes ◽  
Isolated Rat Hepatocytes ◽  
Acid Pathway ◽  
Arachidonic Acid Pathway ◽  
Isolated Rat

Effect of hydrazine upon vitamin B12-dependent methionine synthase activity and the sulphur amino acid pathway in isolated rat hepatocytes

1999 ◽  
Vol 57 (11) ◽  
pp. 1311-1319 ◽  
Author(s):  
Susan H Kenyon ◽  
Catherine J Waterfield ◽  
Daniel S Asker ◽  
Mariko Kudo ◽  
David W Moss ◽  
...  
Keyword(s):  
Amino Acid ◽  
Vitamin B12 ◽  
Rat Hepatocytes ◽  
Methionine Synthase ◽  
Isolated Rat Hepatocytes ◽  
Sulphur Amino Acid ◽  
Acid Pathway ◽  
Isolated Rat

Effects of exogenous phospholipase enzymes, arachidonic acid and 1-oleoyl-2-acetyl-sn-glycerol on ketogenesis in isolated rat hepatocytes

1989 ◽  
Vol 1012 (1) ◽  
pp. 5-9 ◽  
Author(s):  
Masaru Chihara ◽  
Takahide Nomura ◽  
Masakatsu Tachibana ◽  
Hiroko Nomura ◽  
Yukihiko Nomura ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Rat Hepatocytes ◽  
Isolated Rat Hepatocytes ◽  
Isolated Rat

Stimulation of arachidonic acid metabolism by CCl4 in isolated rat hepatocytes

1989 ◽  
Vol 37 (1) ◽  
pp. 23-31 ◽  
Author(s):  
M. Marinovich ◽  
L.M. Flaminio ◽  
M. Papagni ◽  
C.L. Galli
Keyword(s):  
Arachidonic Acid ◽  
Acid Metabolism ◽  
Rat Hepatocytes ◽  
Arachidonic Acid Metabolism ◽  
Isolated Rat Hepatocytes ◽  
Isolated Rat ◽  
Stimulation Of

scholarly journals Endogenous Arachidonic Acid Inhibits Hypotonically-Activated Cl- Channels in Isolated Rat Hepatocytes.

1996 ◽  
Vol 46 (4) ◽  
pp. 311-318 ◽  
Author(s):  
Hideki SAKAI ◽  
Bunpei KAKINOKI ◽  
Martin DIENER ◽  
Noriaki TAKEGUCHI
Keyword(s):  
Arachidonic Acid ◽  
Rat Hepatocytes ◽  
Isolated Rat Hepatocytes ◽  
Cl Channels ◽  
Isolated Rat

Chlorobutanol, a Preservative of Desmopressin, Inhibits Human Platelet Aggregation and Release In Vitro

1990 ◽  
Vol 64 (03) ◽  
pp. 473-477 ◽  
Author(s):  
Shih-Luen Chen ◽  
Wu-Chang Yang ◽  
Tung-Po Huang ◽  
Shiang Wann ◽  
Che-ming Teng
Keyword(s):  
Arachidonic Acid ◽  
Platelet Aggregation ◽  
Atp Release ◽  
Free Calcium ◽  
Dependent Manner ◽  
Antiplatelet Effect ◽  
Human Platelet Aggregation ◽  
Acid Pathway ◽  
Arachidonic Acid Pathway

SummaryTherapeutic preparations of desmopressin for parenteral use contain the preservative chlorobutanol (5 mg/ml). We show here that chlorobutanol is a potent inhibitor of platelet aggregation and release. It exhibited a significant inhibitory activity toward several aggregation inducers in a concentration- and time-dependent manner. Thromboxane B2 formation, ATP release, and elevation of cytosolic free calcium caused by collagen, ADP, epinephrine, arachidonic acid and thrombin respectively were markedly inhibited by chlorobutanol. Chlorobutanol had no effect on elastase- treated platelets and its antiplatelet effect could be reversed. It is concluded that the antiplatelet effect of chlorobutanol is mainly due to its inhibition on the arachidonic acid pathway but it is unlikely to have a nonspecitic toxic effect. This antiplatelet effect of chlorobutanol suggests that desmopressin, when administered for improving hemostasis, should not contain chlorobutanol as a preservative.

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