Bone mineral content in mild primary hyperparathyroidism at three measurement sites before and after removal of a parathyroid adenoma

Abstract. The bone mineral content (BMC) of 35 patients with primary hyperparathyroidism (PHPT) was measured at the mid radius (95% cortical bone) by photon absorptiometry of a 241Am source. The majority of the patients had an overt disease of moderate to severe degree. Average serum calcium of the group was 12.3 mg/100 ml (range 10.6 to 18.0 mg/100 ml). The percentage of normality of the BMC was (Av ± 1 sd) 75.1 ± 13.0% for the whole group. The average increment of BMC in 14 patients 9 to 26 months after parathyroidectomy was 9.9%, with a wide dispersion. However a highly significant negative correlation (r: 0.83; P < 0.01) was found between the initial bone mass and the percentage increment per month after surgery. No further gain was observed 2 years after parathyroidectomy except in one patient with an extremely severe bone loss. In spite of the gain obtained after surgery the bone mass remained markedly diminished in most patients showing that the cortical bone loss caused by PHPT is mainly irreversible.

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Bone mineral content in patients with primary hyperparathyroidism: a comparison of conservative management with surgical treatment

British Journal of Surgery ◽

10.1002/bjs.1800790327 ◽

1992 ◽

Vol 79 (3) ◽

pp. 263-265 ◽

Cited By ~ 17

Author(s):

P. A. Mole ◽

M. H. Walkinshaw ◽

A. Gunn ◽

C. R. Paterson

Keyword(s):

Surgical Treatment ◽

Primary Hyperparathyroidism ◽

Bone Mineral Content ◽

Bone Mineral ◽

Conservative Management ◽

Mineral Content

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Bone Mineral Content in Idiopathic Renal Stone Disease and in Primary Hyperparathyroidism

European Urology ◽

10.1159/000474039 ◽

1983 ◽

Vol 9 (1) ◽

pp. 32-34 ◽

Cited By ~ 33

Author(s):

Michel Fuss ◽

Clémentine Gillet ◽

Jacques Simon ◽

Jean-Claude Vandewalle ◽

André Schoutens ◽

...

Keyword(s):

Primary Hyperparathyroidism ◽

Bone Mineral Content ◽

Bone Mineral ◽

Mineral Content ◽

Renal Stone ◽

Stone Disease ◽

Renal Stone Disease

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BONE MINERAL CONTENT IN PATIENTS WITH PRIMARY HYPERPARATHYROIDISM WITHOUT RADIOLOGICAL EVIDENCE OF SKELETAL CHANGES

Acta Endocrinologica ◽

10.1530/acta.0.0750297 ◽

1974 ◽

Vol 75 (2) ◽

pp. 297-304 ◽

Cited By ~ 40

Author(s):

Nils Dalén ◽

Bo Hjern

Keyword(s):

Primary Hyperparathyroidism ◽

Bone Mineral Content ◽

Distal Radius ◽

Bone Mineral ◽

Mineral Content ◽

Femoral Shaft ◽

Control Group ◽

Skeletal Changes ◽

Radiological Evidence ◽

One Year

ABSTRACT Bone mineral content was determined by X-ray spectrophotometry at 7 sites in 10 patients suffering from primary hyperparathyroidism without any radiological evidence of skeletal alterations. Bone mineral assays were performed before parathyroidectomy and one year after the operation in order to ascertain whether the bone mineral level is abnormal in this disease, and also whether it increases after parathyroidectomy. In comparison with a control-group of 170 subjects the pre-operative level of bone mineral content was low for the distal radius and ulna and the calcaneus, as was the amount of bone mineral per unit volume of cortical bone in the femoral shaft. After parathyroidectomy, the mean bone mineral content for the series increased significantly in the distal radius and ulna, in the femoral neck and the calcaneus.

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BONE MINERALIZATION AND BONE MINERAL CONTENT IN PRIMARY HYPERPARATHYROIDISM

Acta Endocrinologica ◽

10.1530/acta.0.0840314 ◽

1977 ◽

Vol 84 (2) ◽

pp. 314-319 ◽

Cited By ~ 16

Author(s):

Lars Tougaard ◽

Christian Hau ◽

Paul Rødbro ◽

Jørn Ditzel

Keyword(s):

Primary Hyperparathyroidism ◽

Bone Mineral Content ◽

Bone Mineral ◽

Mineral Content ◽

Bone Mineralization ◽

Elevated Serum ◽

Photon Absorptiometry ◽

Mean Values ◽

Bone Biopsies ◽

The Mean

ABSTRACT The degree of bone mineralization and the bone mineral content (BMC) was evaluated in 6 patients with primary hyperparathyroidism. The degree of bone mineralization was estimated as the phosphorus/hydroxyproline ratio (P/Hypro) in bone biopsies; BMC was estimated by photon absorptiometry on both forearms. The mean values of both parameters were significantly lower than normal (P < 0.001 for P/Hypro; P < 0.02 for BMC). As no significant correlation was found between P/Hypro and BMC in hyperparathyroidism, the findings of low values of P/Hypro and of BMC in patients with elevated serum calcium point to primary hyperparathyroidism.

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