Successful treatment of zygomycosis of the paranasal sinuses with surgical debridement and amphotericin B colloidal dispersion

AbstractA case of mucormycosis involving the nose and paranasalsinuses in a 55-year-old man with recently diagnosed acute promyelocytic leukaemia is reported. It was successfully treated with a combination of aggressive surgical debridement and systemic amphotericin B. In addition, local nebulized amphotericin B was used as an adjunct totherapy. We believe this is only the second documented use of nebulized amphotericin in the management of sinonasal mucormycosis. The needfor a high index of suspicion and early aggressive management is emphasized.

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Fungal keratitis caused by Scopulariopsis brevicaulis: successful treatment with topical amphotericin B and chloramphenicol without the need for surgical debridement.

British Journal of Ophthalmology ◽

10.1136/bjo.78.9.730 ◽

1994 ◽

Vol 78 (9) ◽

pp. 730-730 ◽

Cited By ~ 19

Author(s):

A J Lotery ◽

J R Kerr ◽

B A Page

Keyword(s):

Amphotericin B ◽

Successful Treatment ◽

Fungal Keratitis ◽

Surgical Debridement ◽

Scopulariopsis Brevicaulis

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Successful treatment of rhinoorbital mucormycosis due to Rhizopus arrhizus with liposomal amphotericin B, posaconazole and surgical debridement in a child with neuroblastoma

Medical Mycology Case Reports ◽

10.1016/j.mmcr.2019.06.003 ◽

2019 ◽

Vol 25 ◽

pp. 10-14

Author(s):

Kleoniki I. Athanasiadou ◽

Dimitrios I. Athanasiadis ◽

John Constantinidis ◽

Athanasia Anastasiou ◽

Emmanuel Roilides ◽

...

Keyword(s):

Amphotericin B ◽

Successful Treatment ◽

Liposomal Amphotericin ◽

Rhizopus Arrhizus ◽

Surgical Debridement ◽

Liposomal Amphotericin B

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Use of posaconazole in the treatment of infective rhinocerebral mucormycosis

The Journal of Laryngology & Otology ◽

10.1017/s0022215110000678 ◽

2010 ◽

Vol 124 (12) ◽

pp. 1314-1317 ◽

Cited By ~ 4

Author(s):

K Kulendra ◽

M Habibi ◽

C Butler ◽

P Clarke ◽

D Howard

Keyword(s):

Amphotericin B ◽

Paranasal Sinuses ◽

Liposomal Amphotericin ◽

Disease Process ◽

Type Ii Diabetes Mellitus ◽

Surgical Debridement ◽

Liposomal Amphotericin B ◽

Test Results ◽

Drug Induced ◽

Rhinocerebral Mucormycosis

AbstractIntroduction:A patients with undiagnosed type II diabetes mellitus presented with infective rhinocerebral mucormycosis.Investigation results:Initial magnetic resonance imaging scans demonstrated an aggressive disease process involving the left orbit and paranasal sinuses. A repeated scan following treatment excluded intracranial spread or recurrence. Pus from the paranasal sinuses grew Rhizopus arrhizus on microbiological culture.Management:Initial treatment comprised intravenous liposomal amphotericin B, intravenous co-amoxiclav and surgical debridement. The patient's diabetes was managed medically. The development of drug-induced transaminitis required a change of medication. The dose of liposomal amphotericin B was reduced, and then titrated back up as the liver function test results improved. Posaconazole was also introduced and the patient was eventually discharged on this alone, as the maximum recommended cumulative dose of liposomal amphotericin B had been reached.Conclusions:Posaconazole may be used effectively in conjunction with surgical debridement in the treatment of patients with infective rhinocerebral mucormycosis who develop hepatotoxic side effects to liposomal amphotericin B. Posaconazole may also allow a reduction in the dose of liposomal amphotericin B, resulting in better tolerance.

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