Successful treatment of rhinocerebral mucormycosis by a combination of aggressive surgical debridement and the use of systemic liposomal amphotericin B and local therapy with nebulized amphotericin – a case report

1998 ◽  
Vol 112 (4) ◽  
pp. 367-370 ◽  
Author(s):  
P. Raj ◽  
E. J. Vella ◽  
R.C. Bickerton
Keyword(s):  
Case Report ◽  
Amphotericin B ◽  
Successful Treatment ◽  
Acute Promyelocytic Leukaemia ◽  
Liposomal Amphotericin ◽  
Local Therapy ◽  
Surgical Debridement ◽  
Rhinocerebral Mucormycosis ◽  
Aggressive Management ◽  
High Index Of Suspicion

AbstractA case of mucormycosis involving the nose and paranasalsinuses in a 55-year-old man with recently diagnosed acute promyelocytic leukaemia is reported. It was successfully treated with a combination of aggressive surgical debridement and systemic amphotericin B. In addition, local nebulized amphotericin B was used as an adjunct totherapy. We believe this is only the second documented use of nebulized amphotericin in the management of sinonasal mucormycosis. The needfor a high index of suspicion and early aggressive management is emphasized.

Rhinocerebral mucormycosis with orbital and intracranial extension: a case report and review of optimum management

2006 ◽  
Vol 121 (2) ◽  
pp. 192-195 ◽  
Author(s):  
N Munir ◽  
N S Jones
Keyword(s):  
Case Report ◽  
Fungal Infection ◽  
Amphotericin B ◽  
Liposomal Amphotericin ◽  
Surgical Debridement ◽  
Liposomal Amphotericin B ◽  
Intracranial Extension ◽  
Rhinocerebral Mucormycosis ◽  
Optimum Management

Rhinocerebral mucormycosis is a devastating, rapidly progressive and often fatal opportunistic fungal infection predominantly affecting individuals with underlying metabolic and/or immunological compromise. Intracranial extension of the disease has invariably been associated with mortality.We present a review of optimum management of rhinocerebral mucormycosis and a case report of sinonasal mucormycosis with intracranial and orbital extension which was treated successfully with a combination of systemic liposomal amphotericin B therapy and wide surgical debridement.

Another Case Report of Rhinocerebral Mucormycosis Treated with Liposomal Amphotericin B and Surgery

1994 ◽  
Vol 18 (4) ◽  
pp. 653-654 ◽  
Author(s):  
K. K. T. Lim ◽  
M. J. Potts ◽  
D. W. Warnock ◽  
N. B. N. Ibrahim ◽  
E. M. Brown ◽  
...  
Keyword(s):  
Case Report ◽  
Amphotericin B ◽  
Liposomal Amphotericin ◽  
Liposomal Amphotericin B ◽  
Rhinocerebral Mucormycosis

scholarly journals Successful treatment of rhinoorbital mucormycosis due to Rhizopus arrhizus with liposomal amphotericin B, posaconazole and surgical debridement in a child with neuroblastoma

2019 ◽  
Vol 25 ◽  
pp. 10-14
Author(s):  
Kleoniki I. Athanasiadou ◽  
Dimitrios I. Athanasiadis ◽  
John Constantinidis ◽  
Athanasia Anastasiou ◽  
Emmanuel Roilides ◽  
...  
Keyword(s):  
Amphotericin B ◽  
Successful Treatment ◽  
Liposomal Amphotericin ◽  
Rhizopus Arrhizus ◽  
Surgical Debridement ◽  
Liposomal Amphotericin B

scholarly journals Use of posaconazole in the treatment of infective rhinocerebral mucormycosis

2010 ◽  
Vol 124 (12) ◽  
pp. 1314-1317 ◽  
Author(s):  
K Kulendra ◽  
M Habibi ◽  
C Butler ◽  
P Clarke ◽  
D Howard
Keyword(s):  
Amphotericin B ◽  
Paranasal Sinuses ◽  
Liposomal Amphotericin ◽  
Disease Process ◽  
Type Ii Diabetes Mellitus ◽  
Surgical Debridement ◽  
Liposomal Amphotericin B ◽  
Test Results ◽  
Drug Induced ◽  
Rhinocerebral Mucormycosis

AbstractIntroduction:A patients with undiagnosed type II diabetes mellitus presented with infective rhinocerebral mucormycosis.Investigation results:Initial magnetic resonance imaging scans demonstrated an aggressive disease process involving the left orbit and paranasal sinuses. A repeated scan following treatment excluded intracranial spread or recurrence. Pus from the paranasal sinuses grew Rhizopus arrhizus on microbiological culture.Management:Initial treatment comprised intravenous liposomal amphotericin B, intravenous co-amoxiclav and surgical debridement. The patient's diabetes was managed medically. The development of drug-induced transaminitis required a change of medication. The dose of liposomal amphotericin B was reduced, and then titrated back up as the liver function test results improved. Posaconazole was also introduced and the patient was eventually discharged on this alone, as the maximum recommended cumulative dose of liposomal amphotericin B had been reached.Conclusions:Posaconazole may be used effectively in conjunction with surgical debridement in the treatment of patients with infective rhinocerebral mucormycosis who develop hepatotoxic side effects to liposomal amphotericin B. Posaconazole may also allow a reduction in the dose of liposomal amphotericin B, resulting in better tolerance.

scholarly journals Rhinocerebral mucormycosis treated with 32 gram liposomal amphotericin B and incomplete surgery: a case report

2001 ◽  
Vol 1 (1) ◽  
Author(s):  
Atahan A Çagatay ◽  
Serkan S Öncü ◽  
Semra S Çalangu ◽  
Taner T Yildirmak ◽  
Halit H Özsüt ◽  
...  
Keyword(s):  
Case Report ◽  
Amphotericin B ◽  
Liposomal Amphotericin ◽  
Liposomal Amphotericin B ◽  
Rhinocerebral Mucormycosis ◽  
Incomplete Surgery
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