Bidirectional responsiveness of the pituitary-adrenal system in old and young male and female rats

1986 ◽  
Vol 7 (3) ◽  
pp. 153-159 ◽  
Author(s):  
Linda Phillips Brett ◽  
Roger Levine ◽  
Seymour Levine
Keyword(s):  
Young Male ◽  
Female Rats ◽  
Male And Female ◽  
Adrenal System ◽  
Male And Female Rats

Necessity of vitamin B12 for growth of rats fed on an odd- or even-carbon-number fat

1978 ◽  
Vol 39 (3) ◽  
pp. 615-626 ◽  
Author(s):  
J. Bitman ◽  
Joan R. Weyant ◽  
D. L. Wood ◽  
T. R. Wrenn
Keyword(s):  
Carbon Number ◽  
Young Male ◽  
Female Rats ◽  
Vitamin B ◽  
Dietary Energy ◽  
Male And Female ◽  
Glucose Levels ◽  
Male And Female Rats ◽  
Long Chain ◽  
Maize Oil

1. The effect of vitamin B12 on growth was studied in young male and female rats fed on diets sufficient (+B12) or deficient (−B12) in vitamin B12 containing 30% of the dietary energy as fat, either maize oil (CO) or triundecanoin (TUD).2. Vitamin B12 deficiency severely depressed growth. After 6 weeks the weight gain of CO(−B12) rats was only 72% of that of CO(+B12) rats and the gain of TUD(−B12) rats was only 47% of TUD(+B12) rats.3. After fasting 24 or 96 h TUD-fed rats, both + B12 and −B12, had greater glycogen reserves and higher plasma glucose levels than CO-fed rats.4. It is concluded that vitamin B12 is required for the metabolism and utilization of both an odd-carbon-number medium-chain fat, TUD, and an even-C-number long-chain fat, CO, during growth in rats.

scholarly journals Corticosteroid-binding globulin in experimental hypothyroidism in male and female rats

2000 ◽  
Vol 46 (5) ◽  
pp. 35-39
Author(s):  
L. I. Nadolnik ◽  
N. V. Emelyanov ◽  
I. P. Pasteur ◽  
V. V. Vinogradov
Keyword(s):  
Biological Activity ◽  
Thyroid Hormones ◽  
Binding Sites ◽  
Young Male ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Corticosteroid Binding Globulin ◽  
Daily Dose

Main parameters of complex formation of corticosteroid-binding globulin (CSG) were studied in young male and female rats with hypothyrosis induced by mercasolyl in a daily dose of 6 and 30 mg/kg. No pronounced differences in CSG, typical of adult animals, were observed in young rats under conditions of thyroid function inhibition. Steroidand androgen-inhibitory and estrogen-inducing effects of hormones towards CSG did not manifest in hypothyrosis. Decrease in the level of thyroid hormones is characterized by increased affinity of CSG for glucocorticoids and a decrease in the concentration of binding sites. These data indicate that thyroid hormones are the primary regulators of CSG activity. Possibility of modifying CSG affinity and role of this factor in regulation of biological activity of glucocorticoids are discussed.

Effect of acute stress on thymocyte subpopulation in young male and female rats

1997 ◽  
Vol 56 ◽  
pp. 466
Author(s):  
D. Djergovic ◽  
I. Zivkovic ◽  
A. Kezic ◽  
D. Kosec ◽  
M. Lovren ◽  
...  
Keyword(s):  
Acute Stress ◽  
Young Male ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats

CIRCADIAN PERIODICITY AND STRESS RESPONSIVENESS OF THE PITUITARY–ADRENAL SYSTEM OF RATS AFTER CENTRAL ADMINISTRATION OF 6-HYDROXYDOPAMINE

1974 ◽  
Vol 63 (2) ◽  
pp. 299-310 ◽  
Author(s):  
J. KAPLANSKI ◽  
A. M. L. VAN DELFT ◽  
C. NYAKAS ◽  
J. C. STOOF ◽  
P. G. SMELIK
Keyword(s):  
Body Weight ◽  
Female Rats ◽  
Adrenal Weight ◽  
Brain Serotonin ◽  
Central Administration ◽  
Serotonin Content ◽  
Male And Female ◽  
Adrenal System ◽  
Male And Female Rats ◽  
6 Hydroxydopamine

SUMMARY Injection of 250 μg 6-hydroxydopamine (6-OHDA) into the lateral ventricle of adult male and female rats resulted 1 week later in: (1) a lowered brain content of noradrenaline to 20% and dopamine to 40–50% that of control levels but no change in brain serotonin content; (2) a slight reduction in male and no change in female body weight; (3) no change in adrenal weight; (4) minor or no changes in diurnal pituitary–adrenal periodicity or in the responsiveness of this system to ether stress, laparotomy or exposure to a strange environment and handling. Dexamethasone blockade of the diurnal rise in adrenocortical activity was also unchanged. Intracerebral administration of 200 μg 6-OHDA to newborn male and female rats in three sequential doses of 40, 60 and 100 μg, resulted at 12 weeks of age in (1) a lowered brain content of noradrenaline and dopamine to 10% that of control levels but no change in brain serotonin; (2) a 30% decrease in body weight; (3) no change in adrenal weight; (4) minor or no changes in pituitary–adrenal periodicity nor in the responsiveness to ether stress and exposure to a strange environment and handling. When minor changes after 6-OHDA treatment of adult or neonatal rats were found, they always pointed to a stimulatory function of brain catecholamines in pituitary–adrenal activity. It is concluded however that a severe and chronic depletion of brain catecholaminergic systems has no important consequences for the normal functioning of the pituitary–adrenal system.

Interactions of “Ultra-Low” Doses of Naltrexone and Morphine in Mature and Young Male and Female Rats

2004 ◽  
Vol 10 (2) ◽  
pp. 73-81 ◽  
Author(s):  
Scott R. Hamann ◽  
Hammad Malik ◽  
Jewell W. Sloan ◽  
Elzbieta P. Wala
Keyword(s):  
Young Male ◽  
Female Rats ◽  
Low Doses ◽  
Male And Female ◽  
Male And Female Rats
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