scholarly journals Corticosteroid-binding globulin in experimental hypothyroidism in male and female rats

2000 ◽  
Vol 46 (5) ◽  
pp. 35-39
Author(s):  
L. I. Nadolnik ◽  
N. V. Emelyanov ◽  
I. P. Pasteur ◽  
V. V. Vinogradov
Keyword(s):  
Biological Activity ◽  
Thyroid Hormones ◽  
Binding Sites ◽  
Young Male ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Corticosteroid Binding Globulin ◽  
Daily Dose

Main parameters of complex formation of corticosteroid-binding globulin (CSG) were studied in young male and female rats with hypothyrosis induced by mercasolyl in a daily dose of 6 and 30 mg/kg. No pronounced differences in CSG, typical of adult animals, were observed in young rats under conditions of thyroid function inhibition. Steroidand androgen-inhibitory and estrogen-inducing effects of hormones towards CSG did not manifest in hypothyrosis. Decrease in the level of thyroid hormones is characterized by increased affinity of CSG for glucocorticoids and a decrease in the concentration of binding sites. These data indicate that thyroid hormones are the primary regulators of CSG activity. Possibility of modifying CSG affinity and role of this factor in regulation of biological activity of glucocorticoids are discussed.

Studies on progestin binding sites in the hepatic microsomal fraction of male and female rats

1988 ◽  
Vol 117 (4_Suppl) ◽  
pp. S191-S192
Author(s):  
M. STOPPOK ◽  
H. SCHRIEFERS ◽  
E. R. LAX
Keyword(s):  
Binding Sites ◽  
Microsomal Fraction ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats

scholarly journals Role of the oxytocin system in amygdala subregions in the regulation of social interest in male and female rats

Neuroscience ◽  
2016 ◽  
Vol 330 ◽  
pp. 138-149 ◽  
Author(s):  
Kelly M. Dumais ◽  
Andrea G. Alonso ◽  
Remco Bredewold ◽  
Alexa H. Veenema
Keyword(s):  
Social Interest ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats

Necessity of vitamin B12 for growth of rats fed on an odd- or even-carbon-number fat

1978 ◽  
Vol 39 (3) ◽  
pp. 615-626 ◽  
Author(s):  
J. Bitman ◽  
Joan R. Weyant ◽  
D. L. Wood ◽  
T. R. Wrenn
Keyword(s):  
Carbon Number ◽  
Young Male ◽  
Female Rats ◽  
Vitamin B ◽  
Dietary Energy ◽  
Male And Female ◽  
Glucose Levels ◽  
Male And Female Rats ◽  
Long Chain ◽  
Maize Oil

1. The effect of vitamin B12 on growth was studied in young male and female rats fed on diets sufficient (+B12) or deficient (−B12) in vitamin B12 containing 30% of the dietary energy as fat, either maize oil (CO) or triundecanoin (TUD).2. Vitamin B12 deficiency severely depressed growth. After 6 weeks the weight gain of CO(−B12) rats was only 72% of that of CO(+B12) rats and the gain of TUD(−B12) rats was only 47% of TUD(+B12) rats.3. After fasting 24 or 96 h TUD-fed rats, both + B12 and −B12, had greater glycogen reserves and higher plasma glucose levels than CO-fed rats.4. It is concluded that vitamin B12 is required for the metabolism and utilization of both an odd-carbon-number medium-chain fat, TUD, and an even-C-number long-chain fat, CO, during growth in rats.

scholarly journals Age-dependent changes in cocaine sensitivity across early ontogeny in male and female rats: possible role of dorsal striatal D2High receptors

2015 ◽  
Vol 232 (13) ◽  
pp. 2287-2301 ◽  
Author(s):  
Sanders A. McDougall ◽  
Shannon E. Eaton ◽  
Alena Mohd-Yusof ◽  
Cynthia A. Crawford
Keyword(s):  
Early Ontogeny ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Age Dependent
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