Involvement of clathrin light chains in pathology of Alzheimer's disease and pick' S disease: implication for impairment of axonal transport

1994 ◽  
Vol 15 ◽  
pp. S27
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Axonal Transport ◽  
Light Chains

Axonal Transport, Tau Protein, and Neurodegeneration in Alzheimer's Disease

2002 ◽  
Vol 2 (2) ◽  
pp. 151-166 ◽  
Author(s):  
Dick Terwel ◽  
Ilse Dewachter ◽  
Fred Van Leuven
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Axonal Transport ◽  
Tau Protein

scholarly journals Stabilization of dynamic microtubules by mDia1 drives Tau-dependent Aβ1–42 synaptotoxicity

2017 ◽  
Vol 216 (10) ◽  
pp. 3161-3178 ◽  
Author(s):  
Xiaoyi Qu ◽  
Feng Ning Yuan ◽  
Carlo Corona ◽  
Silvia Pasini ◽  
Maria Elena Pero ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Axonal Transport ◽  
Dendritic Spines ◽  
Posttranslational Modifications ◽  
Hippocampal Neurons ◽  
Neuronal Damage ◽  
Driving Factors ◽  
Hyperphosphorylated Tau ◽  
Tau Hyperphosphorylation

Oligomeric Amyloid β1–42 (Aβ) plays a crucial synaptotoxic role in Alzheimer’s disease, and hyperphosphorylated tau facilitates Aβ toxicity. The link between Aβ and tau, however, remains controversial. In this study, we find that in hippocampal neurons, Aβ acutely induces tubulin posttranslational modifications (PTMs) and stabilizes dynamic microtubules (MTs) by reducing their catastrophe frequency. Silencing or acute inhibition of the formin mDia1 suppresses these activities and corrects the synaptotoxicity and deficits of axonal transport induced by Aβ. We explored the mechanism of rescue and found that stabilization of dynamic MTs promotes tau-dependent loss of dendritic spines and tau hyperphosphorylation. Collectively, these results uncover a novel role for mDia1 in Aβ-mediated synaptotoxicity and demonstrate that inhibition of MT dynamics and accumulation of PTMs are driving factors for the induction of tau-mediated neuronal damage.

O3-14-06: AXONAL TRANSPORT AND CYTOSKELETAL THERAPEUTICS IN ALZHEIMER'S DISEASE

2014 ◽  
Vol 10 ◽  
pp. P238-P238
Author(s):  
Donna J. Cross ◽  
Christopher A. Potter ◽  
Nathalie Martin ◽  
Gregory G. Garwin ◽  
Rodney J.Y. Ho ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Axonal Transport

scholarly journals In vivo axonal transport rates decrease in a mouse model of Alzheimer's disease

NeuroImage ◽  
2007 ◽  
Vol 35 (4) ◽  
pp. 1401-1408 ◽  
Author(s):  
Karen Dell Brown Smith ◽  
Verena Kallhoff ◽  
Hui Zheng ◽  
Robia G. Pautler
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Axonal Transport ◽  
Model Of Alzheimer’S Disease

scholarly journals Aluminum alters cell viability and axonal transport system in Alzheimer's disease pathogenic mutation-bearing cells

2004 ◽  
Vol 4 (2) ◽  
pp. 20-23
Author(s):  
Hisashi TANII ◽  
Naohiko MATSUMOTO ◽  
Yujiro KASHIWAGI ◽  
Masayasu OKOCHI ◽  
Toshihisa TANAKA ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Viability ◽  
Axonal Transport ◽  
Transport System ◽  
Pathogenic Mutation

Axonal Transport Defects in Alzheimer’s Disease

2014 ◽  
Vol 51 (3) ◽  
pp. 1309-1321 ◽  
Author(s):  
Zi-Xuan Wang ◽  
Lan Tan ◽  
Jin-Tai Yu
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Axonal Transport
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