HI-6 in man: Blood levels, urinary excretion, and tolerance after intramuscular administration of the oxime to healthy volunteers

The administration of creatine (5 g/day for one month) to 11 young active sportsmen affected their urinary excretion of creatine, creatinine, and thiodiglycolic acid (TDGA) as well as blood levels of homocysteine, vitamin B12 and folates. The probands were divided into four groups, according to the amount of creatine found in urine, and of folates and vitamin B12 determined in blood. The changes of folates and vitamin B12 were mutually reciprocal. Each group utilized CR as donor of one- and two-carbon (1C and 2C) units by means of homocysteine (HoCySH), folates, and vitamin B12, in different metabolic pathways. In 10 men the creatine administration was accompanied by an increase of HoCySH level in blood, while in the last man, with accidentally discovered hyperhomocysteinemia, the HoCySH level dropped by 50 %. Differences between initial and terminal TDGA levels indicate that creatine affects equilibria of redox processes. Creatinine excretion into urine changed in the dependence on the extent of metabolic disturbances.

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A study of thiacetazone blood levels and urinary excretion in man, using high performance liquid chromatography

Leprosy Review ◽

10.5935/0305-7518.19840015 ◽

1984 ◽

Vol 55 (2) ◽

Cited By ~ 1

Author(s):

P. J. JENNER ◽

G. A. ELLARD ◽

O. B. SWAI

Keyword(s):

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

Urinary Excretion ◽

High Performance ◽

Blood Levels

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Plasma levels and urinary excretion of lormetazepam in patients with liver cirrhosis and in healthy volunteers

European Journal of Drug Metabolism and Pharmacokinetics ◽

10.1007/bf03190123 ◽

1990 ◽

Vol 15 (1) ◽

pp. 19-26 ◽

Cited By ~ 6

Author(s):

M. Hildebrand ◽

A. Hellstern ◽

M. Hümpel ◽

D. Hellenbrecht ◽

R. Saller

Keyword(s):

Liver Cirrhosis ◽

Urinary Excretion ◽

Healthy Volunteers ◽

Plasma Levels

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Diflunisal, a New-Acting Analgesic and Prostaglandin Inhibitor: Effect of Concomitant Acetylsalicylic Acid Therapy on Ototoxicity and on Disposition of Both Drugs

Journal of International Medical Research ◽

10.1177/030006057900700110 ◽

1979 ◽

Vol 7 (1) ◽

pp. 61-68 ◽

Cited By ~ 7

Author(s):

P Schulz ◽

C V Perrier ◽

F Ferber-Perret ◽

W J A VandenHeuvel ◽

S L Steelman

Keyword(s):

Single Dose ◽

Urinary Excretion ◽

Acetylsalicylic Acid ◽

Blood Levels ◽

Concomitant Therapy ◽

Significant Drop ◽

Acid Therapy ◽

Prostaglandin Inhibitor ◽

Clinically Significant ◽

Higher Doses

Intermittent and concomitant acetylsalicylic acid (ASA) therapy was superimposed onto a 21-day regimen with diflunisal 250 mg b.i.d. Low doses of ASA (600 mg single dose or 300 mg q.i.d.) did not influence significantly diflunisal blood levels whereas a 600 mg q.i.d. dosing caused a small significant drop, especially at trough level. This drop is not expected to be clinically significant. No ototoxicity could be demonstrated with any treatment of diflunisal though four of fourteen subjects reported mild tinnitus during concomitant therapy at the higher doses of ASA. Diflunisal at 375 mg b.i.d. failed to alter the metabolism of a single dose of labelled ASA (600 mg) as judged by plasma levels, urinary excretion and plasma binding. Daily urinary excretion of prostaglandins E1 and E2 major metabolite was decreased by about 70% by diflunisal.

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Hydroxocobalamin. I. Blood Levels and Urinary Excretion of Vitamin B12 in Man After a Single Parenteral Dose of Aqueous Hydroxocobalamin, Aqueous Cyanocobalamin and Cyanocobalamin Zinc-Tannate Complex

Blood ◽

10.1182/blood.v18.5.511.511 ◽

1961 ◽

Vol 18 (5) ◽

pp. 511-521 ◽

Cited By ~ 23

Author(s):

GEORGE B. JERZY GLASS ◽

HELEN R. SKEGGS ◽

DUK HO LEE ◽

E. LINN JONES ◽

WILLIAM W. HARDY

Keyword(s):

Urinary Excretion ◽

Vitamin B12 ◽

Blood Level ◽

Intramuscular Injection ◽

Serum Vitamin ◽

Blood Levels ◽

Parenteral Dose ◽

Single Intramuscular Injection

Abstract A single intramuscular injection of 500 or 1000 µg. of hydroxocobalamin to 17 individuals resulted in a 1.8- to 4.1-times higher mean serum vitamin B12 blood level, respectively, 5 hours after injection; a 4.6- and 12.8-times higher level 24 hours after injection; a 2.4- and 5.2-times higher level 72 hours after injection, and a 1.6- and 2.4-times higher level by the 2nd through the 4th week after injection than identical doses of cyanocobalamin administered to 19 individuals. The vitamin B12 blood levels following i.m. administration of 500 or 1000 µg. of hydroxocobalamin were significantly higher during the first 24 and 48 hours, respectively, than they were after a cyanocobalamin zinc-tannate complex given to 17 individuals at identical doses. After a single i.m. injection of 500 or 1000 µg. of hydroxocobalamin, an average of only 16 per cent and 27 per cent, respectively, of the vitamin B12 was lost in the 72-hour urines, as compared to 60 per cent and 69 per cent, respectively, after identical doses of cyanocobalamin. These differences, again, were highly significant statistically. The results of these studies give evidence of a slower rate of urinary excretion of hydroxocobalamin as compared to that of cyanocobalamin, and of its ability to build up consistently higher and more prolonged vitamin B12 levels in the blood.

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