Effect of transfer RNA from various sources on placental messenger RNA translation

1983 ◽  
Vol 29 (2) ◽  
pp. 181-195 ◽  
Author(s):  
Susan J. Kelly ◽  
Jean Loria M.T. Gyves ◽  
Judith Ilan
Keyword(s):  
Messenger Rna ◽  
Transfer Rna ◽  
Rna Translation ◽  
Messenger Rna Translation

scholarly journals Cryo-EM visualization of the ribosome in termination complex with apo-RF3 and RF1

eLife ◽  
2013 ◽  
Vol 2 ◽  
Author(s):  
Jesper Pallesen ◽  
Yaser Hashem ◽  
Gürkan Korkmaz ◽  
Ravi Kiran Koripella ◽  
Chenhui Huang ◽  
...  
Keyword(s):  
G Protein ◽  
Messenger Rna ◽  
Stop Codon ◽  
Transfer Rna ◽  
Guanine Nucleotide ◽  
Nucleotide Exchange ◽  
Rna Translation ◽  
Guanine Nucleotide Exchange ◽  
Messenger Rna Translation ◽  
A Site

Termination of messenger RNA translation in Bacteria and Archaea is initiated by release factors (RFs) 1 or 2 recognizing a stop codon in the ribosomal A site and releasing the peptide from the P-site transfer RNA. After release, RF-dissociation is facilitated by the G-protein RF3. Structures of ribosomal complexes with RF1 or RF2 alone or with RF3 alone—RF3 bound to a non-hydrolyzable GTP-analog—have been reported. Here, we present the cryo-EM structure of a post-termination ribosome containing both apo-RF3 and RF1. The conformation of RF3 is distinct from those of free RF3•GDP and ribosome-bound RF3•GDP(C/N)P. Furthermore, the conformation of RF1 differs from those observed in RF3-lacking ribosomal complexes. Our study provides structural keys to the mechanism of guanine nucleotide exchange on RF3 and to an L12-mediated ribosomal recruitment of RF3. In conjunction with previous observations, our data provide the foundation to structurally characterize the complete action cycle of the G-protein RF3.

scholarly journals AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia

Blood ◽  
2014 ◽  
Vol 123 (6) ◽  
pp. 905-913 ◽  
Author(s):  
Erika K. Keeton ◽  
Kristen McEachern ◽  
Keith S. Dillman ◽  
Sangeetha Palakurthi ◽  
Yichen Cao ◽  
...  
Keyword(s):  
Messenger Rna ◽  
Myeloid Leukemia ◽  
Tandem Duplication ◽  
Kinase Inhibitor ◽  
Wild Type ◽  
Internal Tandem Duplication ◽  
Rna Translation ◽  
Key Points ◽  
Messenger Rna Translation ◽  
Flt3 Internal Tandem Duplication

Key Points AZD1208 is a selective pan-Pim kinase inhibitor with efficacy in AML cells, xenografts, and Flt3-internal tandem duplication or Flt3 wild-type patient samples. AML cell growth inhibition is associated with suppression of p70S6K, 4EBP1 phosphorylation, and messenger RNA translation.

scholarly journals Increased Efficiency of Exogenous Messenger RNA Translation in a Krebs Ascites Cell Lysate

1972 ◽  
Vol 69 (5) ◽  
pp. 1299-1303 ◽  
Author(s):  
S. Metafora ◽  
M. Terada ◽  
L. W. Dow ◽  
P. A. Marks ◽  
A. Bank
Keyword(s):  
Messenger Rna ◽  
Ascites Cell ◽  
Rna Translation ◽  
Cell Lysate ◽  
Messenger Rna Translation

scholarly journals Interferon Messenger RNA: Translation in Heterologous Cells

1972 ◽  
Vol 69 (5) ◽  
pp. 1203-1207 ◽  
Author(s):  
J. D. Maeyer-Guignard ◽  
E. D. Maeyer ◽  
L. Montagnier
Keyword(s):  
Messenger Rna ◽  
Rna Translation ◽  
Messenger Rna Translation
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