Frequency-to-voltage conversion in the pyramidal tract neuron: An important role of the inhibitory postsynaptic potential

1985 ◽  
Vol 57 (2) ◽  
pp. 175-180
Author(s):  
Y. Kang ◽  
K. Endo ◽  
T. Araki
Keyword(s):  
Pyramidal Tract ◽  
Inhibitory Postsynaptic Potential ◽  
Postsynaptic Potential ◽  
Voltage Conversion ◽  
Pyramidal Tract Neuron

scholarly journals Role of GABAA inhibition in modulation of pyramidal tract neuron activity during postural corrections

2007 ◽  
Vol 25 (5) ◽  
pp. 1484-1491 ◽  
Author(s):  
Zinaida A. Tamarova ◽  
Mikhail G. Sirota ◽  
Grigori N. Orlovsky ◽  
Tatiana G. Deliagina ◽  
Irina N. Beloozerova
Keyword(s):  
Pyramidal Tract ◽  
Neuron Activity ◽  
Pyramidal Tract Neuron

GABAA and GABAC Receptors Have Contrasting Effects on Excitability in Superior Colliculus

1999 ◽  
Vol 82 (4) ◽  
pp. 2020-2023 ◽  
Author(s):  
Michael Pasternack ◽  
Mathias Boller ◽  
Belinda Pau ◽  
Matthias Schmidt
Keyword(s):  
Superior Colliculus ◽  
Receptor Agonist ◽  
Brain Slices ◽  
Superficial Layer ◽  
Field Potentials ◽  
Competitive Antagonist ◽  
Postsynaptic Potential ◽  
Late Potential ◽  
Receptor Agonists And Antagonists

We have recently found that GABAC receptor subunit transcripts are expressed in the superficial layers of rat superior colliculus (SC). In the present study we used immunocytochemistry to demonstrate the presence of GABAC receptors in rat SC at protein level. We also investigated in acute rat brain slices the effect of GABAA and GABAC receptor agonists and antagonists on stimulus-evoked extracellular field potentials in SC. Electrical stimulation of the SC optic layer induced a biphasic, early and late, potential in the adjacent superficial layer. The late component was completely inhibited by 6-cyano-7-nitroquinoxaline-2,3-dione or CoCl2, indicating that it was generated by postsynaptic activation. Muscimol, a potent GABAA and GABAC receptor agonist, strongly attenuated this postsynaptic potential at concentrations >10 μM. In contrast, the GABAC receptor agonist cis-aminocrotonic acid, as well as muscimol at lower concentrations (0.1–1 μM) increased the postsynaptic potential. This increase was blocked by (1,2,5,6-tetrahydropyridine-4-yl)methylphosphinic acid, a novel competitive antagonist of GABAC receptors. Our findings demonstrate the presence of functional GABAC receptors in SC and suggest a disinhibitory role of these receptors in SC neuronal circuitry.

scholarly journals Intracellular and Computational Characterization of the Intracortical Inhibitory Control of Synchronized Thalamic Inputs In Vivo

1997 ◽  
Vol 78 (1) ◽  
pp. 335-350 ◽  
Author(s):  
Diego Contreras ◽  
Alain Destexhe ◽  
Mircea Steriade
Keyword(s):  
Inhibitory Control ◽  
Computational Models ◽  
Pyramidal Cells ◽  
Excitatory Postsynaptic Potential ◽  
Thalamic Stimulation ◽  
Postsynaptic Potential ◽  
Spike Wave

Contreras, Diego, Alain Destexhe, and Mircea Steriade. Intracellular and computational characterization of the intracortical inhibitory control of synchronized thalamic inputs in vivo. J. Neurophysiol. 78: 335–350, 1997. We investigated the presence and role of local inhibitory cortical control over synchronized thalamic inputs during spindle oscillations (7–14 Hz) by combining intracellular recordings of pyramidal cells in barbiturate-anesthetized cats and computational models. The recordings showed that 1) similar excitatory postsynaptic potential (EPSP)/inhibitory postsynaptic potential (IPSP) sequences occurred either during spindles or following thalamic stimulation; 2) reversed IPSPs with chloride-filled pipettes transformed spindle-related EPSP/IPSP sequences into robust bursts with spike inactivation, resembling paroxysmal depolarizing shifts during seizures; and 3) dual simultaneous impalements showed that inhibition associated with synchronized thalamic inputs is local. Computational models were based on reconstructed pyramidal cells constrained by recordings from the same cells. These models showed that the transformation of EPSP/IPSP sequences into fully developed spike bursts critically needs a relatively high density of inhibitory currents in the soma and proximal dendrites. In addition, models predict significant Ca2+ transients in dendrites due to synchronized thalamic inputs. We conclude that synchronized thalamic inputs are subject to strong inhibitory control within the cortex and propose that 1) local impairment of inhibition contributes to the transformation of spindles into spike-wave-type discharges, and 2) spindle-related inputs trigger Ca2+ events in cortical dendrites that may subserve plasticity phenomena during sleep.

Functional role of regrowing pyramidal tract fibers

1982 ◽  
Vol 211 (3) ◽  
pp. 276-283 ◽  
Author(s):  
Thomas Reh ◽  
Katherine Kalil
Keyword(s):  
Functional Role ◽  
Pyramidal Tract

A depolarizing inhibitory postsynaptic potential activated by synaptically released γ-aminobutyric acid under physiological conditions in rat hippocampal pyramidal cells

1988 ◽  
Vol 66 (8) ◽  
pp. 1100-1102 ◽  
Author(s):  
Paul Perreault ◽  
Massimo Avoli
Keyword(s):  
High Intensity ◽  
Pyramidal Neurons ◽  
Pyramidal Cells ◽  
Rat Hippocampus ◽  
Aminobutyric Acid ◽  
Afferent Stimulation ◽  
Inhibitory Postsynaptic Potential ◽  
Physiological Conditions ◽  
Ca1 Pyramidal Neurons ◽  
Postsynaptic Potential

We report that CA1 pyramidal neurons of the rat hippocampus respond to high intensity afferent stimulation by generating a late depolarizing potential that typically occurs between the early (fast) inhibitory postsynaptic potential (IPSP) and the late (slow) IPSP. This potential is reminiscent of the response seen after the application of 4-aminopyridine and can be blocked by bicuculline, indicating that GABAA receptors are involved in its generation.

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