scholarly journals Quantitative microdialysis determination of extracellular striatal dopamine concentration in male and female rats: effects of estrous cycle and gonadectomy

1994 ◽  
Vol 180 (2) ◽  
pp. 155-158 ◽  
Author(s):  
Li Xiao ◽  
Jill B. Becker
Keyword(s):  
Estrous Cycle ◽  
Striatal Dopamine ◽  
Female Rats ◽  
Male And Female ◽  
Dopamine Concentration ◽  
Male And Female Rats

Effect of Chronic Lead Exposure on Kidney Function in Male and Female Rats: Determination of a Lead Exposure Biomarker

2001 ◽  
Vol 109 (5) ◽  
pp. 457-463 ◽  
Author(s):  
F. Ghorbe ◽  
M. Boujelbene ◽  
F. Makni-Ayadi ◽  
F. Guermazi ◽  
A. Kammoun ◽  
...  
Keyword(s):  
Kidney Function ◽  
Lead Exposure ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Exposure Biomarker ◽  
Chronic Lead Exposure

scholarly journals Gender Differences in the Effect of Prenatal Methamphetamine Exposure and Challenge Dose of Other Drugs on Behavior of Adult Rats

2013 ◽  
pp. S99-S108 ◽  
Author(s):  
R. ŠLAMBEROVÁ ◽  
E. MACÚCHOVÁ ◽  
K. NOHEJLOVÁ-DEYKUN ◽  
B. SCHUTOVÁ ◽  
L. HRUBÁ ◽  
...  
Keyword(s):  
Estrous Cycle ◽  
Adult Male ◽  
Gonadal Hormones ◽  
Female Rats ◽  
Male Rats ◽  
Prenatally Exposed ◽  
Challenge Dose ◽  
Adult Rats ◽  
Male And Female ◽  
Male And Female Rats

The aim of the present study was to compare the response to acute application of several drugs in adult male and female rats prenatally exposed to methamphetamine (MA). Spontaneous locomotor activity and exploratory behavior of adult male and female rats prenatally exposed to MA (5 mg/kg) or saline were tested in a Laboras apparatus (Metris B.V., Netherlands) for 1 h. Challenge dose of the examined drug [amphetamine – 5 mg/kg; cocaine – 5mg/kg; MDMA (3,4-methylenedioxymethamphetamine) – 5 mg/kg; morphine – 5 mg/kg; THC (delta9-tetrahydrocannabinol) – 2 mg/kg] or saline was injected prior to testing. Our data demonstrate that prenatal MA exposure did not affect behavior in male rats with cocaine or morphine treatment, but increased locomotion and exploration in females. Application of amphetamine and MDMA in adulthood increased activity in both sexes, while cocaine and THC only in female rats. Morphine, on the other hand, decreased the activity in the Laboras test in both sexes. As far as sex and estrous cycle is concerned, the present study shows that males were generally less active than females and also females in proestrus-estrus phase of the estrous cycle were more active than females in diestrus. In conclusion, the present study shows that the prenatal MA exposure does not induce general sensitization but affects the sensitivity to drugs dependently to mechanism of drug action and with respect to gonadal hormones.

scholarly journals In vivo determination of body composition by tritium dilution in the rat

1979 ◽  
Vol 41 (3) ◽  
pp. 625-628 ◽  
Author(s):  
Nancy J. Rothwell ◽  
M. J. Stock
Keyword(s):  
Body Water ◽  
Female Rats ◽  
Indirect Methods ◽  
Male And Female ◽  
Male And Female Rats ◽  
Significant Difference ◽  
Total Body ◽  
Direct And Indirect Methods

Total body water was determined in vivo by tritium dilution in thirty-two male and female rats. Body water obtained by tritium dilution and body fat calculated from this value correlated significantly with body water and fat obtained by analysis (r 0.985, 0.855 respectively). There was no significant difference between values for fat assessed by the direct and indirect methods.

Effects of estrogen on striatal dopamine receptor function in male and female rats

1982 ◽  
Vol 16 (2) ◽  
pp. 285-291 ◽  
Author(s):  
Robert E. Hruska ◽  
Lynn M. Ludmer ◽  
Karen T. Pitman ◽  
Marc De Ryck ◽  
Ellen K. Silbergeld
Keyword(s):  
Dopamine Receptor ◽  
Striatal Dopamine ◽  
Female Rats ◽  
Receptor Function ◽  
Male And Female ◽  
Male And Female Rats ◽  
Striatal Dopamine Receptor

Osmotic control of vasopressin in male and female rats

1989 ◽  
Vol 257 (4) ◽  
pp. R738-R743 ◽  
Author(s):  
J. T. Crofton ◽  
L. Share
Keyword(s):  
Estrous Cycle ◽  
Hypertonic Saline ◽  
Plasma Osmolality ◽  
Cardiovascular Responses ◽  
Progressive Increase ◽  
Female Rats ◽  
Male Rats ◽  
Vasopressin Release ◽  
Male And Female ◽  
Male And Female Rats

To examine the osmotic control of vasopressin release, hypertonic saline was infused in conscious unrestrained male rats and female rats in each phase of the estrous cycle. The progressive increase in plasma osmolality was accompanied by a progressive increase in the plasma vasopressin concentration, but the magnitude of the former was smaller in metestrus than in other phases of the cycle and in males (P less than 0.01). The osmotic threshold for vasopressin release was higher in males than in females in each phase of the estrous cycle (P less than 0.05 to P less than 0.01), but the sensitivity of the osmotic control of vasopressin release was similar in male and female rats. Although the pressor response to hypertonic saline was greater in estrous females than in the other females (P less than 0.05 to P less than 0.01), the reduction in blood pressure, after a V1 antagonist 30 min after starting the hypertonic saline infusion, was similar in males and females. Thus there are gender-related differences in the osmotic control of vasopressin release and, in females, cycle-dependent differences in the cardiovascular responses to hypertonic saline.

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