Effects of neonatal handling on the behavior and prolactin stress response in male and female rats at various ages and estrous cycle phases of females

2004 ◽  
Vol 81 (3) ◽  
pp. 489-498 ◽  
Author(s):  
G SEVERINO ◽  
I FOSSATI ◽  
M PADOIN ◽  
C GOMES ◽  
L TREVIZAN ◽  
...  
Keyword(s):  
Stress Response ◽  
Estrous Cycle ◽  
Female Rats ◽  
Male And Female ◽  
Neonatal Handling ◽  
Male And Female Rats

Effects of neonatal handling on the basal forebrain cholinergic system of adult male and female rats

Neuroscience ◽  
2006 ◽  
Vol 142 (2) ◽  
pp. 305-314 ◽  
Author(s):  
S. Pondiki ◽  
A. Stamatakis ◽  
A. Fragkouli ◽  
H. Philippidis ◽  
F. Stylianopoulou
Keyword(s):  
Adult Male ◽  
Basal Forebrain ◽  
Cholinergic System ◽  
Female Rats ◽  
Male And Female ◽  
Neonatal Handling ◽  
Male And Female Rats

Neonatal handling alters learning in adult male and female rats in a task-specific manner

2007 ◽  
Vol 1154 ◽  
pp. 144-153 ◽  
Author(s):  
Therese A. Kosten ◽  
Hongjoo J. Lee ◽  
Jeansok J. Kim
Keyword(s):  
Adult Male ◽  
Female Rats ◽  
Male And Female ◽  
Neonatal Handling ◽  
Male And Female Rats ◽  
Specific Manner

scholarly journals Gender Differences in the Effect of Prenatal Methamphetamine Exposure and Challenge Dose of Other Drugs on Behavior of Adult Rats

2013 ◽  
pp. S99-S108 ◽  
Author(s):  
R. ŠLAMBEROVÁ ◽  
E. MACÚCHOVÁ ◽  
K. NOHEJLOVÁ-DEYKUN ◽  
B. SCHUTOVÁ ◽  
L. HRUBÁ ◽  
...  
Keyword(s):  
Estrous Cycle ◽  
Adult Male ◽  
Gonadal Hormones ◽  
Female Rats ◽  
Male Rats ◽  
Prenatally Exposed ◽  
Challenge Dose ◽  
Adult Rats ◽  
Male And Female ◽  
Male And Female Rats

The aim of the present study was to compare the response to acute application of several drugs in adult male and female rats prenatally exposed to methamphetamine (MA). Spontaneous locomotor activity and exploratory behavior of adult male and female rats prenatally exposed to MA (5 mg/kg) or saline were tested in a Laboras apparatus (Metris B.V., Netherlands) for 1 h. Challenge dose of the examined drug [amphetamine – 5 mg/kg; cocaine – 5mg/kg; MDMA (3,4-methylenedioxymethamphetamine) – 5 mg/kg; morphine – 5 mg/kg; THC (delta9-tetrahydrocannabinol) – 2 mg/kg] or saline was injected prior to testing. Our data demonstrate that prenatal MA exposure did not affect behavior in male rats with cocaine or morphine treatment, but increased locomotion and exploration in females. Application of amphetamine and MDMA in adulthood increased activity in both sexes, while cocaine and THC only in female rats. Morphine, on the other hand, decreased the activity in the Laboras test in both sexes. As far as sex and estrous cycle is concerned, the present study shows that males were generally less active than females and also females in proestrus-estrus phase of the estrous cycle were more active than females in diestrus. In conclusion, the present study shows that the prenatal MA exposure does not induce general sensitization but affects the sensitivity to drugs dependently to mechanism of drug action and with respect to gonadal hormones.

scholarly journals Adolescence and the ontogeny of the hormonal stress response in male and female rats and mice

2016 ◽  
Vol 70 ◽  
pp. 206-216 ◽  
Author(s):  
Russell D. Romeo ◽  
Ravenna Patel ◽  
Laurie Pham ◽  
Veronica M. So
Keyword(s):  
Stress Response ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Rats And Mice

The interaction between prenatal stress and neonatal handling on nociceptive response latencies in male and female rats

1994 ◽  
Vol 55 (5) ◽  
pp. 971-974 ◽  
Author(s):  
James W. Smythe ◽  
Cheryl M. McCormick ◽  
Joseph Rochford ◽  
Michael J. Meaney
Keyword(s):  
Prenatal Stress ◽  
Female Rats ◽  
Nociceptive Response ◽  
Response Latencies ◽  
Male And Female ◽  
Neonatal Handling ◽  
Male And Female Rats

Osmotic control of vasopressin in male and female rats

1989 ◽  
Vol 257 (4) ◽  
pp. R738-R743 ◽  
Author(s):  
J. T. Crofton ◽  
L. Share
Keyword(s):  
Estrous Cycle ◽  
Hypertonic Saline ◽  
Plasma Osmolality ◽  
Cardiovascular Responses ◽  
Progressive Increase ◽  
Female Rats ◽  
Male Rats ◽  
Vasopressin Release ◽  
Male And Female ◽  
Male And Female Rats

To examine the osmotic control of vasopressin release, hypertonic saline was infused in conscious unrestrained male rats and female rats in each phase of the estrous cycle. The progressive increase in plasma osmolality was accompanied by a progressive increase in the plasma vasopressin concentration, but the magnitude of the former was smaller in metestrus than in other phases of the cycle and in males (P less than 0.01). The osmotic threshold for vasopressin release was higher in males than in females in each phase of the estrous cycle (P less than 0.05 to P less than 0.01), but the sensitivity of the osmotic control of vasopressin release was similar in male and female rats. Although the pressor response to hypertonic saline was greater in estrous females than in the other females (P less than 0.05 to P less than 0.01), the reduction in blood pressure, after a V1 antagonist 30 min after starting the hypertonic saline infusion, was similar in males and females. Thus there are gender-related differences in the osmotic control of vasopressin release and, in females, cycle-dependent differences in the cardiovascular responses to hypertonic saline.

scholarly journals Sex-Dependent Effects of Neonatal Inflammation on Adult Inflammatory Markers and Behavior

Endocrinology ◽  
2010 ◽  
Vol 151 (6) ◽  
pp. 2689-2699 ◽  
Author(s):  
A. C. Kentner ◽  
S. A. McLeod ◽  
E. F. Field ◽  
Q. J. Pittman
Keyword(s):  
Estrous Cycle ◽  
Adult Male ◽  
Female Rats ◽  
Sucrose Preference ◽  
Male Rats ◽  
Total Fluid Intake ◽  
Male And Female ◽  
Lps Challenge ◽  
Male And Female Rats ◽  
Cox 2

Inflammatory molecules, such as cyclooxygenase (COX), a prostaglandin synthetic enzyme, have been identified as a marker of depressive symptomology. Previously, we have observed elevated basal COX-2 expression in the hypothalamus of adult male rats treated neonatally with lipopolysaccharide (LPS), which might suggest a phenotype for disrupted hedonic behavior, a symptom of depression. However, COX-2 and its contribution to the expression of anhedonic behavior has not been investigated in these males or in female rats across the estrous cycle, which is the purpose of the current work. Here, we examine the effects of a neonatal LPS challenge or saline on the sucrose preference test as a measure of anhedonia, and hypothalamic COX-2 expression, in adult male and freely cycling female rats. Our data indicate a sex difference in that neonatal LPS at postnatal d 14 causes elevated basal expression of hypothalamic COX-2 in male, but not in female, rats. Additionally, baseline sucrose preference in male and female rats was unaltered as a function of neonatal LPS treatment or estrous cycle stage. In both male and female animals, 50 μg/kg LPS in adulthood caused elevated plasma IL-6 and hypothalamic COX-2 expression in neonatally saline-treated rats but significantly less so in neonatally LPS-treated rats of both sexes; this neonatal programming was not evident for sucrose preference or for total fluid intake (even after much higher doses of LPS). Our data are suggestive of a dissociation between inflammation and anhedonic behavior and a differential effect of neonatal inflammation in males and females.

PITUITARY–ADRENAL FUNCTION IN THYROPARATHYROIDECTOMIZED MALE AND FEMALE RATS

1976 ◽  
Vol 71 (1) ◽  
pp. 47-50 ◽  
Author(s):  
J. D. DUNN ◽  
M. E. HESS
Keyword(s):  
Stress Response ◽  
Peak Plasma ◽  
Plasma Corticosterone ◽  
Adrenal Function ◽  
Female Rats ◽  
Adrenocortical Function ◽  
Dark Phase ◽  
Intact Control ◽  
Male And Female ◽  
Male And Female Rats

SUMMARY The influence of thyroid hormones on pituitary–adrenal function was assessed by studying several aspects of adrenocortical function approximately 30 days after thyroparathyroidectomy (TPTx). Both male and female rats showed evidence of rhythmic adrenocortical activity; peak plasma corticosterone levels occurred just before the dark phase of the lighting schedule. Only the amplitude of the rhythm appeared altered by TPTx. Peak plasma corticosterone levels in TPTx male and female animals were less (P < 0·05) than corresponding levels in intact control rats. Both sexes showed significant responses to stress, but the morning stress response in TPTx females was less (P < 0·01) than the stress response in intact controls. Concomitant with the reduced stress response, the adrenocortical response to exogenous ACTH was reduced in TPTx female rats.

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