Antisense oligodeoxynucleotide attenuates in vivo expression of c-fos in the paraventricular hypothalamic nucleus of the rat brain

1996 ◽  
Vol 209 (2) ◽  
pp. 89-92 ◽  
Author(s):  
Suzanne Quercia ◽  
Sulie L. Chang
1991 ◽  
Vol 59 (2) ◽  
pp. 157-162 ◽  
Author(s):  
Yukiko Uehara-Kunugi ◽  
Kazuhiro Terai ◽  
Takashi Taniguchi ◽  
Ikuo Tooyama ◽  
Hiroshi Kimura

2005 ◽  
Vol 32 (2) ◽  
pp. 108-120 ◽  
Author(s):  
N. A. Platonova ◽  
S. V. Barabanova ◽  
R. G. Povalikhin ◽  
N. V. Tsymbalenko ◽  
M. A. Danilovskii ◽  
...  

2021 ◽  
Author(s):  
Zhi-Li Huang ◽  
Chang-Rui Chen ◽  
Yu-Heng Zhong ◽  
Shan Jiang ◽  
Wei Xu ◽  
...  

Abstract Adequate wakefulness is fundamental for proper daytime functioning. Clinical observations indicate that the paramedian region of the hypothalamus is a critical node for controlling wakefulness. However, the specific nucleus and neural circuitry for this function remain unknown. Here, we found that inhibition of PVHvglut2 neurons induced 3-h increase of NREM sleep. Chemogenetic activation of PVHvglut2 neurons potently induced 9-h wakefulness, and PVHCRH neuronal activation also exerted wakefulness. Photostimulation of PVHvglut2→parabrachial complex/ventral lateral septum circuits immediately drove transitions from NREM to wakefulness. Furthermore, using in vivo fiber photometry or multichannel electrophysiological recordings in mice, we find arousal-dependent increases in population activity of PVHvglut2 neurons. Most importantly, ablation of PVHvglut2 neurons dramatically led mice to hypersomnia-like behaviors. These results demonstrate that PVHvglut2 neurons are essential for physiologic arousal in the hypothalamus.


2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S468-S468
Author(s):  
Jennifer K Callaway ◽  
Christine Molnar ◽  
Song T Yao ◽  
Bevyn Jarrott ◽  
R David Andrew

2013 ◽  
Vol 44 (S 01) ◽  
Author(s):  
M Breu ◽  
D Reisinger ◽  
D Wu ◽  
Y Zhang ◽  
A Fatemi ◽  
...  

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