Alterations in the potassium-evoked release of substance P from the spinal cord of streptozotocin-induced diabetic rats in vitro

1991 ◽  
Vol 22 (6) ◽  
pp. 1093-1096 ◽  
Author(s):  
J. Kamei ◽  
Y. Ogawa ◽  
Y. Ohhashi ◽  
Y. Kasuya
Keyword(s):  
Spinal Cord ◽  
Substance P ◽  
Diabetic Rats

Regulation of neuropeptide release

1980 ◽  
Vol 210 (1178) ◽  
pp. 91-111 ◽  
Keyword(s):  
Spinal Cord ◽  
Substance P ◽  
Gaba Receptors ◽  
Opiate Receptors ◽  
Sensory Nerve ◽  
Substantia Gelatinosa ◽  
Nerve Terminals ◽  
Analgesic Effects ◽  
Spinal Cord Level

The demonstration of depolarization-induced release of substance P, Met- and Leu-enkephalin, somatostatin, neurotensin, vasoactive intestinal polypeptide and cholecystokinin-like material from various regions of rat brain in vitro supports the hypothesis that these and other neuropeptides may act as neurotransmitters. In each case the stimulusevoked release, but not the basal release, of peptide was dependent on the presence of calcium ions in the external medium. The stimulus-evoked release of substance P from nerve terminals in rat substantia nigra may be regulated by presynaptic γ -aminobutyric acid (GABA) receptors. The possible existence of presynaptic opiate receptors on substance P-containing sensory nerve terminals may offer an explanation for the analgesic effects of opiates at spinal cord level, and for the existence of enkephalin neurons in substantia gelatinosa. Capsaicin releases substance P from spinal cord nerve terminals and may impair their function, while having no effect on substance P neurons in supraspinal regions. The possibility of cosecretion of peptide and amine products from the same cells is discussed.

scholarly journals Bombesin-Like, Substance P and Vasoactive Intestinal Polypeptide Receptors in Fetal Cortical Homografts to Host Cortex and Spinal Cord

1989 ◽  
Vol 1 (3-4) ◽  
pp. 105-112 ◽  
Author(s):  
Terry W. Moody ◽  
Reina L. Getz ◽  
William J. Goldberg ◽  
Jerald J. Bernstein
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Substance P ◽  
Vasoactive Intestinal Polypeptide ◽  
Peptide Receptors ◽  
Adult Rat ◽  
Graft Donor ◽  
Intestinal Polypeptide

Neuropeptide receptors were visualized in homografts of fetal cortex (E14) into adult rat cortex (immediate or 7 day delay) and spinal cord usingin vitroautoradiographic techniques to explore the expression of peptide receptors in the same graft tissue in different central nervous system implantation sites. Receptors for bombesin (BN)-like peptides developed in the grafts by 3 weeks postimplantation regardless of location or age of implantation pocket in host. After 4 weeks, the density of BN receptors was confined to the graft. In grafts to spinal cord, however, high densities of BN-like receptors were not confined to the graft but were distributed throughout the spinal cord. In contrast, the density of vasoactive intestinal polypeptide (VIP) and substance P (SP) receptors was moderate and low to undetectable in the fetal grafts. The development of the peptide receptors studied was graft donor tissue specific since they were not altered by central nervous system implantation site.

Lack of effect of baclofen on substance P and somatostatin release from the spinal cord in vitro

1982 ◽  
Vol 319 (1) ◽  
pp. 78-81 ◽  
Author(s):  
J. Sawynok ◽  
N. Kato ◽  
V. Havlicek ◽  
F. S. LaBella
Keyword(s):  
Spinal Cord ◽  
Substance P
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