A mathematical model for brain edema: The relationship between brain tissue water content and intracranial pressure

1992 ◽  
Vol 37 (2) ◽  
pp. 63-64 ◽  
Author(s):  
M.E. Weinand
1981 ◽  
Vol 50 (3) ◽  
pp. 566-574 ◽  
Author(s):  
E. E. Nattie ◽  
W. H. Edwards

We studied the response of blood, cerebrospinal fluid (CSF), and brain ionic composition and acid-base status as well as ventilation to acute respiratory acidosis (FICO2 0.08) in lightly anesthetized newborn puppies. Control puppy plasma ions and CSF-plasma ionic distribution ratios were essentially adultlike while in blood a mild, compensated respiratory acidosis was present, and in CSF, PCO2 and [HCO3-] were slightly higher than in adults. Brain tissue water content was higher in puppy vs. adult; the Cl- space was greater; the content of [Na+], [Cl-], and [HCO3-] were higher and [K+] lower. During respiratory acidosis, CSF [HCO3-] increased 2.0 mmol/l by 15 min and 6.2 mmol/l by 3 h, a response quantitatively like that observed in the adult. The quantity, CSF [Na+] -- [Cl-], increased stoichiometrically with CSF [HCO3-], indicating the mechanistic involvement of these ions in the CSF [HCO3-] response. In brain tissue, water content, [Cl-], and the [Cl-] space were unchanged, but by 3 h [Na+] and [HCO3-] were increased. Ventilation was stimulated but the response expressed as ml.min-1.Torr-1.body wt-1 was less in puppy than in adult.


Radiology ◽  
2007 ◽  
Vol 243 (3) ◽  
pp. 720-726 ◽  
Author(s):  
Imanuel Dzialowski ◽  
Ernst Klotz ◽  
Sophia Goericke ◽  
Arnd Doerfler ◽  
Michael Forsting ◽  
...  

Brain Edema ◽  
1985 ◽  
pp. 360-366 ◽  
Author(s):  
S. Inao ◽  
H. Kuchiwaki ◽  
N. Hirai ◽  
S. Takada ◽  
N. Kageyama ◽  
...  

2005 ◽  
Vol 18 (8) ◽  
pp. 499-506 ◽  
Author(s):  
Emmanuel L. Barbier ◽  
Lijun Liu ◽  
Emmanuelle Grillon ◽  
Jean-François Payen ◽  
Jean-François Lebas ◽  
...  

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