Brain tissue water content in patients with idiopathic normal pressure hydrocephalus

2006 ◽  
pp. 348-351 ◽  
Author(s):  
G. Aygok ◽  
A. Marmarou ◽  
P. Fatouros ◽  
H. Young
Keyword(s):  
Water Content ◽  
Brain Tissue ◽  
Normal Pressure Hydrocephalus ◽  
Normal Pressure ◽  
Idiopathic Normal Pressure Hydrocephalus ◽  
Tissue Water Content ◽  
Tissue Water

scholarly journals Increased interstitial fluid in periventricular and deep white matter hyperintensities in patients with suspected idiopathic normal pressure hydrocephalus

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Alexander Rau ◽  
Marco Reisert ◽  
Elias Kellner ◽  
Jonas A. Hosp ◽  
Horst Urbach ◽  
...  
Keyword(s):  
White Matter ◽  
Water Content ◽  
Normal Pressure Hydrocephalus ◽  
Interstitial Fluid ◽  
White Matter Hyperintensities ◽  
Free Water ◽  
Normal Pressure ◽  
Idiopathic Normal Pressure Hydrocephalus ◽  
Imaging Features ◽  
Deep White Matter

AbstractPeriventricular white matter changes are common in patients with idiopathic normal pressure hydrocephalus (iNPH) and considered to represent focally elevated interstitial fluid. We compared diffusion measures in periventricular hyperintensities in patients with imaging features of iNPH to patients without. The hypothesis is that periventricular hyperintensities in patients with presumed iNPH show higher water content than in patients without imaging features of iNPH. 21 patients with iNPH Radscale 7–12 (“high probability of iNPH”) and 10 patients with iNPH Radscale 2–4 (“low probability of iNPH”) were examined with a neurodegeneration imaging protocol including a diffusion microstructure imaging sequence. Periventricular hyperintensities and deep white matter hyperintensities were segmented and diffusion measures were compared. In patients with imaging features of iNPH, the free water content in periventricular hyperintensities was significantly higher compared to the control group (p = 0.005). This effect was also detectable in deep white matter hyperintensities (p = 0.024). Total brain volumes and total gray or white matter volumes did not differ between the groups. Periventricular cap free water fraction was highly discriminative regarding patients with presumed iNPH and controls with an ROC AUC of 0.933. Quantitative diffusion microstructure imaging shows elevated water content in periventricular hyperintensities in patients with imaging features of iNPH, which could be the imaging correlate for pathologic fluid accumulation and may be used as an imaging biomarker in the future.

CSF acid-base regulation and ventilation during acute hypercapnia in the newborn dog

1981 ◽  
Vol 50 (3) ◽  
pp. 566-574 ◽  
Author(s):  
E. E. Nattie ◽  
W. H. Edwards
Keyword(s):  
Water Content ◽  
Brain Tissue ◽  
Ionic Composition ◽  
Respiratory Acidosis ◽  
Tissue Water Content ◽  
Acid Base ◽  
Tissue Water ◽  
Plasma Ions ◽  
Ionic Distribution ◽  
Acid Base Status

We studied the response of blood, cerebrospinal fluid (CSF), and brain ionic composition and acid-base status as well as ventilation to acute respiratory acidosis (FICO2 0.08) in lightly anesthetized newborn puppies. Control puppy plasma ions and CSF-plasma ionic distribution ratios were essentially adultlike while in blood a mild, compensated respiratory acidosis was present, and in CSF, PCO2 and [HCO3-] were slightly higher than in adults. Brain tissue water content was higher in puppy vs. adult; the Cl- space was greater; the content of [Na+], [Cl-], and [HCO3-] were higher and [K+] lower. During respiratory acidosis, CSF [HCO3-] increased 2.0 mmol/l by 15 min and 6.2 mmol/l by 3 h, a response quantitatively like that observed in the adult. The quantity, CSF [Na+] -- [Cl-], increased stoichiometrically with CSF [HCO3-], indicating the mechanistic involvement of these ions in the CSF [HCO3-] response. In brain tissue, water content, [Cl-], and the [Cl-] space were unchanged, but by 3 h [Na+] and [HCO3-] were increased. Ventilation was stimulated but the response expressed as ml.min-1.Torr-1.body wt-1 was less in puppy than in adult.

Ischemic Brain Tissue Water Content: CT Monitoring during Middle Cerebral Artery Occlusion and Reperfusion in Rats1

Radiology ◽  
2007 ◽  
Vol 243 (3) ◽  
pp. 720-726 ◽  
Author(s):  
Imanuel Dzialowski ◽  
Ernst Klotz ◽  
Sophia Goericke ◽  
Arnd Doerfler ◽  
Michael Forsting ◽  
...  
Keyword(s):  
Middle Cerebral Artery ◽  
Water Content ◽  
Middle Cerebral Artery Occlusion ◽  
Brain Tissue ◽  
Artery Occlusion ◽  
Tissue Water Content ◽  
Tissue Water ◽  
Ischemic Brain ◽  
Ischemic Brain Tissue ◽  
Cerebral Artery Occlusion

Brain tissue Aβ42 levels are linked to shunt response in idiopathic normal pressure hydrocephalus

2018 ◽  
Vol 130 (1) ◽  
pp. 121-129 ◽  
Author(s):  
Sami Abu Hamdeh ◽  
Johan Virhammar ◽  
Dag Sehlin ◽  
Irina Alafuzoff ◽  
Kristina Giuliana Cesarini ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Normal Pressure Hydrocephalus ◽  
Surgical Outcome ◽  
Normal Pressure ◽  
Idiopathic Normal Pressure Hydrocephalus ◽  
Csf Biomarkers ◽  
Vp Shunt ◽  
Tissue Levels ◽  
Shunt Procedure ◽  
Shunt Treatment

OBJECTIVEThe authors conducted a study to test if the cortical brain tissue levels of soluble amyloid beta (Aβ) reflect the propensity of cortical Aβ aggregate formation and may be an additional factor predicting surgical outcome following idiopathic normal pressure hydrocephalus (iNPH) treatment.METHODSHighly selective ELISAs (enzyme-linked immunosorbent assays) were used to quantify soluble Aβ40, Aβ42, and neurotoxic Aβ oligomers/protofibrils, associated with Aβ aggregation, in cortical biopsy samples obtained in patients with iNPH (n = 20), sampled during ventriculoperitoneal (VP) shunt surgery. Patients underwent pre- and postoperative (3-month) clinical assessment with a modified iNPH scale. The preoperative CSF biomarkers and the levels of soluble and insoluble Aβ species in cortical biopsy samples were analyzed for their association with a favorable outcome following the VP shunt procedure, defined as a ≥ 5-point increase in the iNPH scale.RESULTSThe brain tissue levels of Aβ42 were negatively correlated with CSF Aβ42 (Spearman’s r = −0.53, p < 0.05). The Aβ40, Aβ42, and Aβ oligomer/protofibril levels in cortical biopsy samples were higher in patients with insoluble cortical Aβ aggregates (p < 0.05). The preoperative CSF Aβ42 levels were similar in patients responding (n = 11) and not responding (n = 9) to VP shunt treatment at 3 months postsurgery. In contrast, the presence of cortical Aβ aggregates and high brain tissue Aβ42 levels were associated with a poor outcome following VP shunt treatment (p < 0.05).CONCLUSIONSBrain tissue measurements of soluble Aβ species are feasible. Since high Aβ42 levels in cortical biopsy samples obtained in patients with iNPH indicated a poor surgical outcome, tissue levels of Aβ species may be associated with the clinical response to shunt treatment.

Focal brain ischemia in rat: acute changes in brain tissueT1 reflect acute increase in brain tissue water content

2005 ◽  
Vol 18 (8) ◽  
pp. 499-506 ◽  
Author(s):  
Emmanuel L. Barbier ◽  
Lijun Liu ◽  
Emmanuelle Grillon ◽  
Jean-François Payen ◽  
Jean-François Lebas ◽  
...  
Keyword(s):  
Water Content ◽  
Brain Tissue ◽  
Brain Ischemia ◽  
Tissue Water Content ◽  
Tissue Water ◽  
Acute Increase ◽  
Acute Changes ◽  
Focal Brain Ischemia
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