Regulation of ribosomal RNA transcription by growth rate of the hyperthermophilic Archaeon, Pyrococcus furiosus

1993 ◽  
Vol 111 (2-3) ◽  
pp. 159-164 ◽  
Author(s):  
J DiRuggiero
Keyword(s):  
Growth Rate ◽  
Ribosomal Rna ◽  
Pyrococcus Furiosus ◽  
Rna Transcription ◽  
Hyperthermophilic Archaeon

scholarly journals Regulation of ribosomal RNA transcription by growth rate of the hyperthermophilic Archaeon,Pyrococcus furiosus

1993 ◽  
Vol 111 (2-3) ◽  
pp. 159-164 ◽  
Author(s):  
Jocelyne DiRuggiero ◽  
Laurie A. Achenbach ◽  
Stephen H. Brown ◽  
Robert M. Kelly ◽  
Frank T. Robb
Keyword(s):  
Growth Rate ◽  
Ribosomal Rna ◽  
Pyrococcus Furiosus ◽  
Rna Transcription ◽  
Hyperthermophilic Archaeon

scholarly journals How Cancer Exploits Ribosomal RNA Biogenesis: A Journey beyond the Boundaries of rRNA Transcription

Cells ◽  
2019 ◽  
Vol 8 (9) ◽  
pp. 1098 ◽  
Author(s):  
Gaviraghi ◽  
Vivori ◽  
Tonon
Keyword(s):  
Growth Rate ◽  
Cancer Cells ◽  
Ribosomal Rna ◽  
Tumor Suppressors ◽  
Ribosome Biogenesis ◽  
Regulatory Networks ◽  
Protein Translation ◽  
Rna Transcription ◽  
Rrna Transcription ◽  
Rna Biogenesis

The generation of new ribosomes is a coordinated process essential to sustain cell growth. As such, it is tightly regulated according to cell needs. As cancer cells require intense protein translation to ensure their enhanced growth rate, they exploit various mechanisms to boost ribosome biogenesis. In this review, we will summarize how oncogenes and tumor suppressors modulate the biosynthesis of the RNA component of ribosomes, starting from the description of well-characterized pathways that converge on ribosomal RNA transcription while including novel insights that reveal unexpected regulatory networks hacked by cancer cells to unleash ribosome production.

Regulation of eukaryotic ribosomal RNA transcription by RNA polymerase modification

Cell ◽  
1986 ◽  
Vol 47 (3) ◽  
pp. 445-450 ◽  
Author(s):  
Erik Bateman ◽  
Marvin R. Paule
Keyword(s):  
Rna Polymerase ◽  
Ribosomal Rna ◽  
Rna Transcription

scholarly journals BLM helicase facilitates RNA polymerase I-mediated ribosomal RNA transcription

2011 ◽  
Vol 21 (5) ◽  
pp. 1172-1183 ◽  
Author(s):  
Patrick M. Grierson ◽  
Kate Lillard ◽  
Gregory K. Behbehani ◽  
Kelly A. Combs ◽  
Saumitri Bhattacharyya ◽  
...  
Keyword(s):  
Rna Polymerase ◽  
Ribosomal Rna ◽  
Rna Polymerase I ◽  
Rna Transcription ◽  
Blm Helicase ◽  
Polymerase I

Zinc-finger protein 545 is a novel tumour suppressor that acts by inhibiting ribosomal RNA transcription in gastric cancer

Gut ◽  
2012 ◽  
Vol 62 (6) ◽  
pp. 833-841 ◽  
Author(s):  
Shiyan Wang ◽  
Yingduan Cheng ◽  
Wan Du ◽  
Leina Lu ◽  
Liang Zhou ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Zinc Finger ◽  
Ribosomal Rna ◽  
Zinc Finger Protein ◽  
Tumour Suppressor ◽  
Rna Transcription ◽  
Finger Protein

scholarly journals A Novel DNA Polymerase Family Found inArchaea

1998 ◽  
Vol 180 (8) ◽  
pp. 2232-2236 ◽  
Author(s):  
Yoshizumi Ishino ◽  
Kayoko Komori ◽  
Isaac K. O. Cann ◽  
Yosuke Koga
Keyword(s):  
Escherichia Coli ◽  
Dna Polymerase ◽  
Pyrococcus Furiosus ◽  
Dna Polymerases ◽  
Open Reading Frames ◽  
Gene Products ◽  
Polymerase Gene ◽  
Hyperthermophilic Archaeon ◽  
Dna Polymerase Ii ◽  
Reading Frames

ABSTRACT One of the most puzzling results from the complete genome sequence of the methanogenic archaeon Methanococcus jannaschii was that the organism may have only one DNA polymerase gene. This is because no other DNA polymerase-like open reading frames (ORFs) were found besides one ORF having the typical α-like DNA polymerase (family B). Recently, we identified the genes of DNA polymerase II (the second DNA polymerase) from the hyperthermophilic archaeonPyrococcus furiosus, which has also at least one α-like DNA polymerase (T. Uemori, Y. Sato, I. Kato, H. Doi, and Y. Ishino, Genes Cells 2:499–512, 1997). The genes in M. jannaschiiencoding the proteins that are homologous to the DNA polymerase II ofP. furiosus have been located and cloned. The gene products of M. jannaschii expressed in Escherichia colihad both DNA polymerizing and 3′→5′ exonuclease activities. We propose here a novel DNA polymerase family which is entirely different from other hitherto-described DNA polymerases.

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