Fetal central blood circulation in the third trimester of normal pregnancy - a longitudinal study. I. Aortic and umbilical blood flow

1986 ◽  
Vol 13 (2) ◽  
pp. 137-150 ◽  
Author(s):  
Göran Lingman ◽  
Karel Maršal
Keyword(s):  
Blood Flow ◽  
Longitudinal Study ◽  
Blood Circulation ◽  
Normal Pregnancy ◽  
Third Trimester ◽  
The Third ◽  
Umbilical Blood ◽  
Umbilical Blood Flow

Role of ductus venosus in distribution of umbilical blood flow in human fetuses during second half of pregnancy

2000 ◽  
Vol 279 (3) ◽  
pp. H1256-H1263 ◽  
Author(s):  
Maria Bellotti ◽  
Giancarlo Pennati ◽  
Camilla De Gasperi ◽  
Frederick C. Battaglia ◽  
Enrico Ferrazzi
Keyword(s):  
Blood Flow ◽  
Fetal Liver ◽  
Color Doppler ◽  
Liver Perfusion ◽  
Normal Pregnancy ◽  
Left Lobe ◽  
Ductus Venosus ◽  
Venous Circulation ◽  
Umbilical Blood ◽  
Umbilical Blood Flow

Color Doppler sonography was used to study umbilical and ductus venosus (DV) flow in 137 normal fetuses between 20 and 38 wk of gestation. Hepatic flows were also evaluated. In all parts of the venous circulation examined, blood flow increased significantly with advancing gestational age. The weight-specific amniotic umbilical flow did not change significantly during gestation (120 ± 44 ml · min−1 · kg−1), whereas DV flow decreased significantly (from 60 to 17 ml · min−1 · kg−1). The percentage of umbilical blood flow shunted through the DV decreased significantly (from 40% to 15%); consequently, the percentage of flow to the liver increased. The right lobe flow changed from 20 to 45%, whereas the left lobe flow was approximately constant (40%). These changes are related to different patterns of growth of the umbilical veins and DV diameters. The present data support the hypothesis that the DV plays a less important role in shunting well-oxygenated blood to the brain and myocardium in late normal pregnancy than in early gestation, which leads to increased fetal liver perfusion.

The Assessment of the Umbilical Blood Flow of the Surviving Twin after the Intrauterine Death of the Other Twin

1996 ◽  
Vol 45 (3) ◽  
pp. 383-386 ◽  
Author(s):  
W. Malinowski ◽  
W. Dec ◽  
I. Biskup
Keyword(s):  
First Trimester ◽  
The Other ◽  
Intrauterine Death ◽  
Second Trimester ◽  
Third Trimester ◽  
Venous Flow ◽  
The Third ◽  
Diastolic Flow ◽  
Umbilical Blood ◽  
Umbilical Blood Flow

AbstractThis paper summarizes our experience with Doppler velocimetry in survivors of intrauterine co-twin demise. In the first trimester, ten dichorionic deaths occurred; none of the survivors developed flow disorders. During the second trimester, there were three intrauterine demises, two of them were monochorionic and the survivors developed flow disorders: one presented transitory venous flow aberration, the other one an impaired development of diastolic flow. In the third trimester, two intrauterine deaths occurred. One case of twin to twin transfusion syndrome (TTTS) was complicated by the donor's death and the recipient showed a loss of diastolic flow. The second one happened during a dichorionic twin pregnancy. The survivor presented high systolic/diastolic daily ratio (S/D = 7.8).

scholarly journals Trimester effects of source-specific PM10 on birth weight outcomes in the Avon Longitudinal Study of Parents and Children (ALSPAC)

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Yingxin Chen ◽  
Susan Hodgson ◽  
John Gulliver ◽  
Raquel Granell ◽  
A. John Henderson ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Birth Weight ◽  
Regression Models ◽  
Linear Regression Models ◽  
Exposure Misclassification ◽  
Third Trimester ◽  
Residential History ◽  
The Third ◽  
Parents And Children ◽  
Avon Longitudinal Study

Abstract Background Evidence suggests that exposure to particulate matter with aerodynamic diameter less than 10 μm (PM10) is associated with reduced birth weight, but information is limited on the sources of PM10 and exposure misclassification from assigning exposures to place of residence at birth. Methods Trimester and source-specific PM10 exposures (PM10 from road source, local non-road source, and total source) in pregnancy were estimated using dispersion models and a full maternal residential history for 12,020 births from the Avon longitudinal study of parents and children (ALSPAC) cohort in 1990–1992 in the Bristol area. Information on birth outcomes were obtained from birth records. Maternal sociodemographic and lifestyle factors were obtained from questionnaires. We used linear regression models for continuous outcomes (birth weight, head circumference (HC), and birth length (BL) and logistic regression models for binary outcomes (preterm birth (PTB), term low birth weight (TLBW) and small for gestational age (SGA)). Sensitivity analysis was performed using multiple imputation for missing covariate data. Results After adjustment, interquartile range increases in source specific PM10 from traffic were associated with 17 to 18% increased odds of TLBW in all pregnancy periods. We also found odds of TLBW increased by 40% (OR: 1.40, 95%CI: 1.12, 1.75) and odds of SGA increased by 18% (OR: 1.18, 95%CI: 1.05, 1.32) per IQR (6.54 μg/m3) increase of total PM10 exposure in the third trimester. Conclusion This study adds to evidence that maternal PM10 exposures affect birth weight, with particular concern in relation to exposures to PM10 from road transport sources; results for total PM10 suggest greatest effect in the third trimester. Effect size estimates relate to exposures in the 1990s and are higher than those for recent studies – this may relate to reduced exposure misclassification through use of full residential history information, changes in air pollution toxicity over time and/or residual confounding.

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