scholarly journals Prognostic implications of left artial spontaneous echo contrast in nonvalvular atrial fibrillation

1994 ◽  
Vol 24 (3) ◽  
pp. 755-762 ◽  
Author(s):  
Dominic Y.C. Leung ◽  
Ian W. Black ◽  
Gregory B. Cranney ◽  
Andrew P. Hopkins ◽  
Warren F. Walsh
Keyword(s):  
Atrial Fibrillation ◽  
Nonvalvular Atrial Fibrillation ◽  
Spontaneous Echo Contrast ◽  
Prognostic Implications

scholarly journals Hematologic correlates of left atrial spontaneous echo contrast and thromboembolism in nonvalvular atrial fibrillation

1993 ◽  
Vol 21 (2) ◽  
pp. 451-457 ◽  
Author(s):  
Ian W. Black ◽  
Colin N. Chesterman ◽  
Andrew P. Hopkins ◽  
Lincoln C.L. Lee ◽  
Beng H. Chong ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Left Atrial ◽  
Nonvalvular Atrial Fibrillation ◽  
Spontaneous Echo Contrast

scholarly journals CHA2DS2-VASc Score as a Predictor for Left Atrial Thrombus or Spontaneous Echo Contrast in Patients with Nonvalvular Atrial Fibrillation: A Meta-Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Ping Sun ◽  
Zhi Hao Guo ◽  
Hong Bin Zhang
Keyword(s):  
Atrial Fibrillation ◽  
Sensitivity Analysis ◽  
Publication Bias ◽  
Left Atrial ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Left Atrial Thrombus ◽  
Nonvalvular Atrial Fibrillation ◽  
Atrial Thrombus ◽  
Spontaneous Echo Contrast

Objective. This meta-analysis aimed at exploring the predictive value of CHA2DS2-VASc score for the left atrial thrombus (LAT) or left atrial spontaneous echo contrast (LASEC) in patients with nonvalvular atrial fibrillation (NVAF). Methods. PubMed, Embase, Web of Science, ScienceDirect, Cochrane Library, and Chinese core journals of the CNKI and Wanfang databases were searched to identify all the relevant papers that were published up to January 2020. The data were extracted for pooled odds ratios (ORs) with 95% confidence intervals (CIs), heterogeneity, subgroup, publication bias, and sensitivity analysis. Results. Overall, 15 studies containing 6223 patients with NVAF were enrolled. All studies were evaluated for LAT, and 12 studies were evaluated for LASEC. The pooled analysis using a random-effects model showed that a high CHA2DS2-VASc score was related with LAT/LASEC (pooled OR=1.59, 95% CI: 1.35–1.88, P<0.001) with high heterogeneity (I2=76.9%, P<0.001) and LAT (pooled OR=1.83, 95% CI: 1.44–2.33, P<0.001) with high heterogeneity (I2=79.4%, P<0.001). The subgroup analysis demonstrated that the sample size may be the main source of heterogeneity. Although the Begg’s funnel plot based on 15 studies for LAT/LASEC (P=0.029) and 12 studies for LAT (P=0.046) indicated the presence of publication bias among the included studies, the trim-and-fill method verified the stability of the pooled outcomes. In addition, sensitivity analysis indicated that all effects were stable. Conclusion. The results of this meta-analysis showed that the CHA2DS2-VASc score is related with LAT and LASEC in patients with NVAF. However, more studies are warranted to address this issue.

scholarly journals Dabigatran exhibits low intensity of left atrial spontaneous echo contrast in patients with nonvalvular atrial fibrillation as compared with warfarin

2016 ◽  
Vol 32 (3) ◽  
pp. 326-332 ◽  
Author(s):  
Tetsuya Watanabe ◽  
Yukinori Shinoda ◽  
Kuniyasu Ikeoka ◽  
Hirooki Inui ◽  
Hidetada Fukuoka ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Left Atrial ◽  
Nonvalvular Atrial Fibrillation ◽  
Spontaneous Echo Contrast ◽  
Low Intensity

Abstract WP183: Spontaneous Echo Contrast is Associated With Larger Cerebral Infarction Volume in Stroke Patients With Atrial Fibrillation

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
JoonNyung Heo ◽  
Kyoungsub Kim ◽  
Joonsang Yoo ◽  
Young Dae Kim ◽  
Hyo Suk Nam ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Cerebral Infarction ◽  
Clinical Information ◽  
Interquartile Range ◽  
Stroke Patients ◽  
Nonvalvular Atrial Fibrillation ◽  
Severe Stroke ◽  
Spontaneous Echo Contrast ◽  
Infarction Volume ◽  
Scale Scores

Introduction: The presence of spontaneous echo contrast (SEC) on transesophageal echocardiography (TEE) is associated with increased thrombogenecity and a risk factor of thromboembolism. The increased thrombogenecity in SEC may produce larger intracardiac thrombi, which result in larger cerebral infarctions and severe stroke. Hypothesis: We hypothesized that infarction volume will be larger in stroke patients with SEC than in those without SEC. Methods: This was a post-hoc analysis using a prospective cohort of acute ischemic stroke. This study included patients with nonvalvular atrial fibrillation (NVAF) who underwent TEE and diffusion weighted imaging (DWI) from Jan. 2008 to Dec. 2014. The volume of cerebral infarction on DWI was measured semi-automatically using 3-dimensional software by an investigator who was blinded to clinical information. The infarction volume was compared between patients with SEC and those without. Results: Of 4252 considered patients, 889 patients had NVAF. After excluding 449 patients without TEE and 39 patients without DWI, 401 patients were included for analysis. Of them, SEC was found in 181 patients (45.1%, 82 mild, 35 moderate, and 64 severe SEC). Infarction volume was larger for the patients with SEC than those without SEC (median [interquartile range], 7226.8 mm 3 [1218.1-28804.6] vs. 4756.8 mm 3 [672.8-14887.8], p=0.015). Infarction volume also increased with SEC severity (p=0.006). Initial National Institute of Health Stroke Scale scores were higher for the patients with SEC than those without SEC (median [interquartile range], 5.0 [2.0-12.0] vs. 3.0 [1.0-8.0]. p=0.008). On multivariate analysis, infarction volume was independently associated with the presence of SEC (p=0.014). Conclusion: Among stroke patients with NVAF, those with co-existing SEC had larger cerebral infarction, which may account for severe stroke. This may be related with increased thrombogenecity in patients with SEC.

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