In vivo and in vitro effects of graded doses of the pesticide heptachlor on female sex steroid hormone production in rats

1995 ◽  
Vol 111 (2) ◽  
pp. 191-196 ◽  
Author(s):  
J.A. Oduma ◽  
E.O. Wango ◽  
D. Oduor-Okelo ◽  
D.W. Makawiti ◽  
H. Odongo
Keyword(s):  
Steroid Hormone ◽  
Sex Steroid ◽  
Hormone Production ◽  
Sex Steroid Hormone ◽  
Female Sex ◽  
In Vitro Effects

scholarly journals Changes in melatonin and sex steroid hormone production among men as a result of rotating night shift work – the HORMONIT study

2021 ◽  
Author(s):  
Barbara N Harding ◽  
Gemma Castaño-Vinyals ◽  
Anna Palomar-Cros ◽  
Kyriaki Papantoniou ◽  
Ana Espinosa ◽  
...  
Keyword(s):  
Shift Work ◽  
Steroid Hormone ◽  
Night Shift ◽  
Sex Steroid ◽  
Hormone Production ◽  
Night Shift Work ◽  
Sex Steroid Hormone

scholarly journals Sex differences in viral entry protein expression, host responses to SARS-CoV-2, and in vitro responses to sex steroid hormone treatment in COVID-19

2020 ◽  
Author(s):  
Mengying Sun ◽  
Rama Shankar ◽  
Meehyun Ko ◽  
Christopher Daniel Chang ◽  
Shan-Ju Yeh ◽  
...  
Keyword(s):  
Gene Expression ◽  
Sex Differences ◽  
Steroid Hormone ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Hormone Treatment ◽  
Host Responses ◽  
Sex Steroid ◽  
Sex Steroid Hormone

Abstract Epidemiological studies suggest that men exhibit a higher mortality rate to COVID-19 than women, yet the underlying biology is largely unknown. Here, we seek to delineate sex differences in the expression of entry genes ACE2 and TMPRSS2, host responses to SARS-CoV-2, and in vitro responses to sex steroid hormone treatment. Using over 220,000 human gene expression profiles covering a wide range of age, tissues, and diseases, we found that male samples show higher expression levels of ACE2 and TMPRSS2, especially in the older group (>60 years) and in the kidney. Analysis of 6,031 COVID-19 patients at Mount Sinai Health System revealed that men have significantly higher creatinine levels, an indicator of impaired kidney function. Further analysis of 782 COVID-19 patient gene expression profiles taken from upper airway and blood suggested men and women present profound expression differences in responses to SARS-CoV-2. Computational deconvolution analysis of these profiles revealed male COVID-19 patients have enriched kidney-specific mesangial cells in blood compared to healthy patients. Finally, we observed selective estrogen receptor modulators, but not other hormone drugs (agonists/antagonists of estrogen, androgen, and progesterone), could reduce SARS-CoV-2 infection in vitro.

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