scholarly journals The Acute Effects of Reserpine and NSD-1015 on the Brain Serotonin Synthesis Rate Measured by an Autoradiographic Method

1995 ◽  
Vol 12 (3) ◽  
pp. 251-262 ◽  
Author(s):  
D Mück-Seler
Keyword(s):  
Brain Serotonin ◽  
Synthesis Rate ◽  
Acute Effects ◽  
Serotonin Synthesis ◽  
Autoradiographic Method ◽  
The Brain

scholarly journals A New Method to Measure Brain Serotonin Synthesis in vivo. II. A Practical Autoradiographic Method Tested in Normal and Lithium-Treated Rats

1990 ◽  
Vol 10 (1) ◽  
pp. 13-21 ◽  
Author(s):  
S. Nagahiro ◽  
A. Takada ◽  
M. Diksic ◽  
T. L. Sourkes ◽  
K. Missala ◽  
...  
Keyword(s):  
Tryptophan Hydroxylase ◽  
Lithium Treatment ◽  
Point Method ◽  
Synthesis Rate ◽  
Serotonin Synthesis ◽  
Autoradiographic Method ◽  
The Brain ◽  
Cerebral Structures ◽  
Time Point

We describe here a practical autoradiographic method to estimate the rate of serotonin synthesis in brain. A two-time point method (60 and 150 min after injection of a-[14C]methyl-l-tryptophan) was first evaluated in 14 normal rats (7 at each time point). After this the method was tested in lithium-treated rats. In normal rats the rate of serotonin synthesis measured by the two-time point method generally correlated with known concentrations of tryptophan hydroxylase. The rate of synthesis in lithium-treated rats was compared with that in shamtreated rats (NaCl treatment). The results showed a significant increase in the synthesis rate in some cerebral structures. The greatest increases in the serotonin synthesis rate, attributable to the lithium treatment, were observed in the parietal cortex (52%) and caudate nucleus (47%). This is the first investigation to demonstrate, with autoradiographic resolution (∼100 μm), the differential changes in the rate of serotonin synthesis in the brain. Lithium had no significant effect on the rate of synthesis in the pineal gland.

scholarly journals Role of a Functional SNP of the Gene Coding Brain Serotonin Synthesis Rate-Limiting Enzyme Tph2 in Dilated Cardiomyopathy

2020 ◽  
Vol 118 (3) ◽  
pp. 426a
Author(s):  
Sachio Morimoto ◽  
Kengo Hayamizu ◽  
Miki Nonaka ◽  
Lei Li ◽  
Yuanyuan Wang
Keyword(s):  
Dilated Cardiomyopathy ◽  
Brain Serotonin ◽  
Synthesis Rate ◽  
Serotonin Synthesis ◽  
Gene Coding ◽  
Rate Limiting ◽  
Functional Snp

Dissociation of morphine tolerance and dependence from brain serotonin synthesis rate in mice

1972 ◽  
Vol 21 (5) ◽  
pp. 751-753 ◽  
Author(s):  
Paul J. Schechter ◽  
Walter Lovenberq ◽  
Albert Sjoerdsma
Keyword(s):  
Morphine Tolerance ◽  
Brain Serotonin ◽  
Synthesis Rate ◽  
Serotonin Synthesis

A simplified autoradiographic method with α-[14C]methyl-tryptophan to measure serotonin synthesis rate in the rat brain

2004 ◽  
Vol 31 (8) ◽  
pp. 1013-1019
Author(s):  
Hidehiko Okazawa ◽  
Sadahiko Nishizawa ◽  
Tatsuro Tsuchida ◽  
Yoshiharu Yonekura ◽  
Mirko Diksic
Keyword(s):  
Rat Brain ◽  
Synthesis Rate ◽  
Serotonin Synthesis ◽  
Autoradiographic Method

scholarly journals Acute effects of combining citalopram and pindolol on regional brain serotonin synthesis in sham operated and olfactory bulbectomized rats

2009 ◽  
Vol 54 (3-4) ◽  
pp. 161-171 ◽  
Author(s):  
Khanh Q. Nguyen ◽  
Yoshihiro Tohyama ◽  
Arata Watanabe ◽  
Shu Hasegawa ◽  
Ivan Skelin ◽  
...  
Keyword(s):  
Brain Serotonin ◽  
Acute Effects ◽  
Serotonin Synthesis ◽  
Regional Brain
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