scholarly journals Role of a Functional SNP of the Gene Coding Brain Serotonin Synthesis Rate-Limiting Enzyme Tph2 in Dilated Cardiomyopathy

2020 ◽  
Vol 118 (3) ◽  
pp. 426a
Author(s):  
Sachio Morimoto ◽  
Kengo Hayamizu ◽  
Miki Nonaka ◽  
Lei Li ◽  
Yuanyuan Wang
Keyword(s):  
Dilated Cardiomyopathy ◽  
Brain Serotonin ◽  
Synthesis Rate ◽  
Serotonin Synthesis ◽  
Gene Coding ◽  
Rate Limiting ◽  
Functional Snp

InTERTesting association between telomerase, mTOR and phytochemicals

2012 ◽  
Vol 14 ◽  
Author(s):  
Tabetha Sundin ◽  
Patricia Hentosh
Keyword(s):  
Dna Sequences ◽  
Mammalian Target Of Rapamycin ◽  
Heat Shock Protein 90 ◽  
Protein Translation ◽  
Telomerase Activity ◽  
Gene Coding ◽  
Functional Complex ◽  
Telomerase Regulation ◽  
Rate Limiting

Telomeres are stretches of repeated DNA sequences located at the ends of chromosomes that are necessary to prevent loss of gene-coding DNA regions during replication. Telomerase – the enzyme responsible for immortalising cancer cells through the addition of telomeric repeats – is active in ~90% of human cancers. Telomerase activity is inhibited by various phytochemicals such as isoprenoids, genistein, curcumin, epigallocatechin-3-gallate, resveratrol and others. Human TERT (telomerase reverse transcriptase – the rate-limiting component of telomerase), heat shock protein 90, Akt, p70 S6 kinase (S6K) and mammalian target of rapamycin (mTOR) form a physical and functional complex with one another. The inclusion of Akt, mTOR and S6K in the TERT complex is compelling evidence to support mTOR-mediated control of telomerase activity. This review will define the role of mTOR, the master regulator of protein translation, in telomerase regulation and provide additional insights into the numerous ways in which telomerase activity is hindered by phytochemicals.

Dissociation of morphine tolerance and dependence from brain serotonin synthesis rate in mice

1972 ◽  
Vol 21 (5) ◽  
pp. 751-753 ◽  
Author(s):  
Paul J. Schechter ◽  
Walter Lovenberq ◽  
Albert Sjoerdsma
Keyword(s):  
Morphine Tolerance ◽  
Brain Serotonin ◽  
Synthesis Rate ◽  
Serotonin Synthesis

scholarly journals TPH1 gene polymorphism rs211105 influences serotonin and tryptophan hydroxylase 1 concentrations in acute pancreatitis patients

2021 ◽  
Author(s):  
Jadwiga Snarska ◽  
Ewa Fiedorowicz ◽  
Dominika Rozmus ◽  
Konrad Wroński ◽  
Maria Latacz ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Metabolic Pathway ◽  
Tryptophan Hydroxylase ◽  
Control Group ◽  
Nucleotide Polymorphisms ◽  
Serotonin Synthesis ◽  
Single Nucleotide ◽  
Factors Affecting ◽  
Rate Limiting

Abstract Background The role of serotonin and its metabolic pathway in proper functioning of the pancreas has not been thoroughly investigated yet in acute pancreatitis (AP) patients. Tryptophan hydroxylase (TPH) as the rate-limiting enzyme of serotonin synthesis has been considered for possible associations in various diseases. Single-nucleotide polymorphisms (SNPs) in TPH genes have been already described in associations with psychiatric and digestive system disorders. This study aimed to explore the association of a rs211105 (T/G) polymorphism in TPH1 gene with tryptophan hydroxylase 1 concentrations in blood serum in a population of acute pancreatitis patients, and to investigate this association with acute pancreatitis susceptibility. Results Our data showed an association between the presence of the T allele at the position rs211105 (OR = 2.47, 95% CI: 0.94-6.50, p = 0.06) under conditions of a decreased AP incidence. For TT and GT genotypes in the control group, the lowest concentration of TPH was associated with higher serotonin levels (TT: Rs=-0.415, p=0.0018; GT: Rs=-0,457, p=0.0066), while for the AP group the highest levels of TPH among the TT genotype were associated with lower levels of serotonin (TT: Rs=-0.749, p<0.0001, and in the GG genotype higher levels of TPH were associated with higher levels of serotonin (GG: Rs=-0.738, p=0.037). Conclusions Here, a new insight in the potential role of a selected genetic factor in pancreatitis development was shown. Not only the metabolic pathway of serotonin, but also factors affecting serotonin synthesis may be interesting and important points in acute pancreatitis.

Tryptophan-Free Diets: A Physiological Tool to Study Brain Serotonin Function

Physiology ◽  
2000 ◽  
Vol 15 (5) ◽  
pp. 260-264 ◽  
Author(s):  
F. Fadda
Keyword(s):  
Sexual Behavior ◽  
Brain Serotonin ◽  
Laboratory Animals ◽  
Serotonin Synthesis

Tryptophan-free diets produce a specific reduction of brain serotonin synthesis and release. This method for lowering neural serotonin function has been extensively used in both laboratory animals and humans to study the role of serotonin in a variety of behaviors, such as aggressiveness, sleep, sexual behavior, anxiety, mood, memory, and so forth.

scholarly journals Biochemical and Autoradiographic Measurements of Brain Serotonin Synthesis Rate in the Freely Moving Rat

2002 ◽  
Vol 72 (6) ◽  
pp. 2593-2600 ◽  
Author(s):  
Abdallah Gharib ◽  
Cédar Balende ◽  
Nicole Sarda ◽  
Dinah Weissmann ◽  
Alain Plenevaux ◽  
...  
Keyword(s):  
Brain Serotonin ◽  
Synthesis Rate ◽  
Serotonin Synthesis ◽  
Freely Moving

REDUCTION IN BRAIN SEROTONIN SYNTHESIS RATE IN STREPTOZOTOCIN-DIABETIC RATS1

Endocrinology ◽  
1981 ◽  
Vol 109 (1) ◽  
pp. 310-312 ◽  
Author(s):  
ELIZABETH A. CRANDALL ◽  
MARCIA A. GILLIS ◽  
JOHN D. FERNSTROM
Keyword(s):  
Brain Serotonin ◽  
Synthesis Rate ◽  
Serotonin Synthesis

scholarly journals TPH1 Gene Polymorphism (rs211105) Influences Serotonin and Tryptophan Hydroxylase 1 Concentrations in Acute Pancreatitis Patients

2021 ◽  
Author(s):  
Jadwiga Snarska ◽  
Ewa Fiedorowicz ◽  
Dominika Rozmus ◽  
Konrad Wroński ◽  
Maria Latacz ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Metabolic Pathway ◽  
Tryptophan Hydroxylase ◽  
Control Group ◽  
Nucleotide Polymorphisms ◽  
Serotonin Synthesis ◽  
Single Nucleotide ◽  
Factors Affecting ◽  
Rate Limiting

Abstract Background: The role of serotonin and its metabolic pathway in the proper functioning of the pancreas has not been thoroughly investigated yet in the aspect of AP (acute pancreatitis). Tryptophan hydroxylase (TPH) as the rate-limiting enzyme of serotonin synthesis has been considered for possible associations in various diseases. Single-nucleotide polymorphisms (SNPs) in TPH genes have been already described in associations with psychiatric and digestive system disorders. Aim of this study was to explore association of rs211105 (T/G) polymorphism in TPH1 gene with tryptophan hydroxylase 1 concentrations in blood serum in population of acute pancreatitis patients, and to investigate this association with acute pancreatitis susceptibility. Results: To date, we have found an association between the presence of the T allele at the position rs211105 (OR = 2.47, 95% CI: 0.94-6.50, p = 0.06) under conditions of a decreased AP incidence. For TT and GT genotype in control group, the lowest concentration of TPH was associated with higher serotonin levels (TT: Rs=-0.415, p=0.0018; GT: Rs=-0,457, p=0.0066), while for AP group: the highest levels of TPH among TT genotype were associated with lower levels of serotonin (TT: Rs=-0.749, p=0.0000), and in GG genotype higher levels of TPH were associated with higher levels of serotonin (GG: Rs=-0.738, p=0.037).Conclusions: Here, the new insight of the potential role of selected genetic factor in pancreatitis development was brought. Not only the metabolic pathway of serotonin, but also factors affecting serotonin synthesis may be interesting and important point in acute pancreatitis.

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