Is the therapeutic effect of clozapine associated with epileptogenic activity in deep brain nuclei?

1993 ◽  
Vol 9 (2-3) ◽  
pp. 236 ◽  
Author(s):  
D.D. Denney ◽  
J.R. Stevens
Keyword(s):  
Therapeutic Effect ◽  
Brain Nuclei ◽  
Deep Brain

Prospective Imaging Trial Assessing Gadoteridol Retention in the Deep Brain Nuclei of Women Undergoing Breast MRI

2020 ◽  
Vol 27 (12) ◽  
pp. 1734-1741
Author(s):  
Colleen H. Neal ◽  
Akshat C. Pujara ◽  
Ashok Srinivasan ◽  
Thomas L. Chenevert ◽  
Dariya Malyarenko ◽  
...  
Keyword(s):  
Breast Mri ◽  
Brain Nuclei ◽  
Deep Brain

Spatiotemporal Pattern of Gadodiamide-Related T1 Hyperintensity Increase Within the Deep Brain Nuclei

2018 ◽  
Vol 53 (12) ◽  
pp. 748-754 ◽  
Author(s):  
Guillaume P.O. Marie ◽  
Polona Pozeg ◽  
Reto A. Meuli ◽  
Philippe Maeder ◽  
Joachim Forget
Keyword(s):  
Spatiotemporal Pattern ◽  
Brain Nuclei ◽  
T1 Hyperintensity ◽  
Deep Brain

Arousal by stimulation of deep-brain nuclei

Nature ◽  
2008 ◽  
Vol 452 (7183) ◽  
pp. E1-E1 ◽  
Author(s):  
Hugh Staunton
Keyword(s):  
Brain Nuclei ◽  
Deep Brain ◽  
Stimulation Of

scholarly journals Advanced MRI techniques for transcranial high intensity focused ultrasound targeting

Brain ◽  
2020 ◽  
Vol 143 (9) ◽  
pp. 2664-2672
Author(s):  
Bhavya R Shah ◽  
Vance T Lehman ◽  
Timothy J Kaufmann ◽  
Daniel Blezek ◽  
Jeff Waugh ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Magnetic Resonance ◽  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Brain Nuclei ◽  
Intermediate Nucleus ◽  
Mri Sequences ◽  
Ventral Intermediate Nucleus ◽  
Deep Brain

Abstract Magnetic resonance guided high intensity focused ultrasound is a novel, non-invasive, image-guided procedure that is able to ablate intracranial tissue with submillimetre precision. It is currently FDA approved for essential tremor and tremor dominant Parkinson’s disease. The aim of this update is to review the limitations of current landmark-based targeting techniques of the ventral intermediate nucleus and demonstrate the role of emerging imaging techniques that are relevant for both magnetic resonance guided high intensity focused ultrasound and deep brain stimulation. A significant limitation of standard MRI sequences is that the ventral intermediate nucleus, dentatorubrothalamic tract, and other deep brain nuclei cannot be clearly identified. This paper provides original, annotated images demarcating the ventral intermediate nucleus, dentatorubrothalamic tract, and other deep brain nuclei on advanced MRI sequences such as fast grey matter acquisition T1 inversion recovery, quantitative susceptibility mapping, susceptibility weighted imaging, and diffusion tensor imaging tractography. Additionally, the paper reviews clinical efficacy of targeting with these novel MRI techniques when compared to current established landmark-based targeting techniques. The paper has widespread applicability to both deep brain stimulation and magnetic resonance guided high intensity focused ultrasound.

scholarly journals Deep Brain Nuclei T1 Shortening after Gadobenate Dimeglumine in Children: Influence of Radiation and Chemotherapy

2017 ◽  
Vol 39 (1) ◽  
pp. 24-30 ◽  
Author(s):  
S. Kinner ◽  
T.B. Schubert ◽  
R.J. Bruce ◽  
S.L. Rebsamen ◽  
C.A. Diamond ◽  
...  
Keyword(s):  
Gadobenate Dimeglumine ◽  
Brain Nuclei ◽  
Deep Brain

scholarly journals Deep brain stimulation for aggressiveness: long-term follow-up and tractography study of the stimulated brain areas

2020 ◽  
pp. 1-10 ◽  
Author(s):  
Cristina V. Torres ◽  
Guillermo Blasco ◽  
Marta Navas García ◽  
Elena Ezquiaga ◽  
Jesús Pastor ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Ventral Tegmental Area ◽  
Therapeutic Effect ◽  
Brain Stimulation ◽  
Medial Forebrain Bundle ◽  
Diffusion Tensor ◽  
Long Term Outcome ◽  
Ventral Tegmental ◽  
Deep Brain

OBJECTIVEInitial studies applying deep brain stimulation (DBS) of the posteromedial hypothalamus (PMH) to patients with pathological aggressiveness have yielded encouraging results. However, the anatomical structures involved in its therapeutic effect have not been precisely identified. The authors’ objective was to describe the long-term outcome in their 7-patient series, and the tractography analysis of the volumes of tissue activated in 2 of the responders.METHODSThis was a retrospective study of 7 subjects with pathological aggressiveness. The findings on MRI with diffusion tensor imaging (DTI) in 2 of the responders were analyzed. The authors generated volumes of tissue activated according to the parameters used, and selected those volumes as regions of interest to delineate the tracts affected by stimulation.RESULTSThe series consisted of 5 men and 2 women. Of the 7 patients, 5 significantly improved with stimulation. The PMH, ventral tegmental area, dorsal longitudinal fasciculus, and medial forebrain bundle seem to be involved in the stimulation field.CONCLUSIONSIn this series, 5 of 7 medication-resistant patients with severe aggressiveness who were treated with bilateral PMH DBS showed a significant long-lasting improvement. The PMH, ventral tegmental area, dorsal longitudinal fasciculus, and medial forebrain bundle seem to be in the stimulation field and might be responsible for the therapeutic effect of DBS.

scholarly journals Deep Brain Stimulation Effects on Olfactory Dysfunction of Parkinson’s Disease - A Meta-Analysis

2020 ◽  
Author(s):  
Chao Li ◽  
Xue-lian Chu ◽  
Min Tian ◽  
Feng Li ◽  
Shu-jun Xu ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Publication Bias ◽  
Therapeutic Effect ◽  
Brain Stimulation ◽  
Early Stage ◽  
Meta Analysis ◽  
Olfactory Function ◽  
Efficient Treatment ◽  
Stimulation Parameters ◽  
Deep Brain

Abstract Background: Non-motor symptoms in PD usually arise at very early stage and suffer the damage decades from diagnose. Deep brain stimulation (DBS) is considered as a highly efficient treatment option for PD’s motor function. However, the effect of DBS on NMS, especially hyposmia, has not been fully understood and there are contradictory data among different researches.Objective: The objective of this study was to evaluate the therapeutic effect of DBS on hyposmia in PD patients with a cohort study and identified whether the olfactory function scores influence the final surgery effect.Methods: A meta-analysis including six studies with 326 patients were conducted to evaluate the exact therapeutic effect of DBS on hyposmia in PD. Sub-group analyses based on sample size, gender, stimulation parameters were carried out to distinguish the difference. Sensitivity analysis was conducted to evaluate studies’ heterogeneity and stability. Potential publication bias were evaluated by Egger’s tests and the funnel plots.Results: Our study showed that DBS had clearly improved olfactory function in Parkinson patients (P < 0.0001) and the group heterogeneity as well as the publication bias advocate the convince of the result (Heterogeneity: Chi² = 6.39, df = 5 (P = 0.38); I² = 22%). Subgroup analysis also found that different groups of gender, education level or stimulation parameters have no obvious discrepancy on olfactory function improvement except age groups.Conclusion: In summary, this article summarize studies about DBS and hyposmia and offer evidences for the notion that DBS has authentic therapeutic value on the hyposmia in PD.

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