Radiation hypersensitivity of LEC strain rats controlled by a single autosomal recessive gene

An analysis of data from 599 Merino sheep has provided clear evidence that a condition of goitre, existing on 26 properties spread throughout the more closely settled parts of South Australia, is simply inherited. It is suggested that the condition is due to the action of an autosomal recessive gene whose action shows high penetrance and variable expressivity, and is accompanied by manifold phenotypic effects themselves equally variable in expression. This suggestion accords well with biochemical studies of goitrous sheep taken from among this sample. This study is continuing.

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Hereditary hepatitis of LEC rats is controlled by a single autosomal recessive gene

Laboratory Animals ◽

10.1258/002367788780864402 ◽

1988 ◽

Vol 22 (2) ◽

pp. 166-169 ◽

Cited By ~ 61

Author(s):

R. Masuda ◽

M. C. Yoshida ◽

M. Sasaki ◽

K. Dempo ◽

M. Mori

Keyword(s):

Autosomal Recessive ◽

Recessive Gene ◽

Histological Features ◽

Hepatocellular Carcinomas ◽

History Of ◽

Preneoplastic Foci ◽

Lec Rats ◽

Autosomal Recessive Gene ◽

Hepatic Lesions ◽

One Year

The natural history of hereditary hepatitis in long-survived LEC rats was reported. Among 56 (female: male, 28:28) LEC rats of F30, 16 (8:8) (29%) died of fulminant hepatitis approximately four months after birth. The remaining 40 (20:20) rats that survived more than one year developed chronic hepatitis and subsequent hepatic lesions including hepatocellular carcinomas. Further study made with 32 F31 rats killed at the age of five months revealed that hepatitis occurred in all of these rats. Genetic analysis performed by various crosses of LEC and LEJ rats confirmed the previous result that hereditary hepatitis was caused by a single autosomal recessive gene. F1 hybrid rats never developed hepatitis, showing normal histology of the liver. Histological features of hepatitis in F2 (F1×1) and backcross (F1×LEC) rats were the same as those observed in the LEC rats. The preneoplastic foci also appeared in some of these hybrid rats at the age of eight months. We propose a gene symbol hts to designate the present hepatitis which is assumed to be homozygous in LEC strain rats.

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Genetic studies of a new mutant strain showing shivering in the mouse

Laboratory Animals ◽

10.1258/002367796780739817 ◽

1996 ◽

Vol 30 (4) ◽

pp. 365-368

Author(s):

X. Guo ◽

T. Nobunaga ◽

H. Katoh

Keyword(s):

Life Span ◽

Mutant Strain ◽

Congenic Strain ◽

Autosomal Recessive ◽

Recessive Gene ◽

Donor Strain ◽

Genetic Studies ◽

Genetic Analyses ◽

Autosomal Recessive Gene ◽

The Cross

A new mutant with shivering, Hula dance Sendai (tentatively named hus gene), was found in the IVCE strain. A congenic strain, C57BL/6JJcl- hus, was established by the cross-intercross method using IVCE- hus as the donor strain and C57BL/6JJcl as the recipient. No significant differences were observed in the age of the onset of shivering and life span between B6- hus and IVCE- hus mice. Genetic analyses demonstrated that this mutation is governed by an autosomal recessive gene ( Mbphus) and is an allele of the Mbpshi gene (Chr.18)

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XIII.—The Genetic Basis of Alkaptonuria

Proceedings of the Royal Society of Edinburgh ◽

10.1017/s0370164600019532 ◽

1933 ◽

Vol 52 ◽

pp. 264-295 ◽

Cited By ~ 26

Author(s):

Lancelot Hogben ◽

R. L. Worrall ◽

I. Zieve

Keyword(s):

Autosomal Recessive ◽

Genetic Basis ◽

Random Mating ◽

Recessive Gene ◽

Overwhelming Majority ◽

Alternative Form ◽

Gene Substitution ◽

Autosomal Recessive Gene

Summary1. The overwhelming majority of cases of alkaptonuria are consistent with the hypothesis that this disease is determined by a single autosomal recessive gene substitution.2. The observed proportion of alkaptonurics in recorded fraternities with two normal parents and the incidence of consanguineous parentage conform quantitatively to the requirements of Mendelian hypothesis in a system of random mating.3. There appears to be an alternative form of alkaptonuria which is dominant.Grateful acknowledgment is made to Sir Archibald Garrod for advice regarding the sources consulted.

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Observations on the Hereditary Nature of Hageman Trait

Blood ◽

10.1182/blood.v11.6.565.565 ◽

1956 ◽

Vol 11 (6) ◽

pp. 565-569 ◽

Cited By ~ 18

Author(s):

ALVIN MARGOLIUS ◽

OSCAR D. RATNOFF

Keyword(s):

Blood Coagulation ◽

Autosomal Recessive ◽

Recessive Gene ◽

Family Tree ◽

The Family ◽

Autosomal Recessive Gene ◽

Hereditary Nature ◽

As If

Abstract A study was made of the family tree of two sisters with Hageman trait, an asymptomatic disorder of blood coagulation. In this family the defect behaves genetically as if it is due to the transmission of an autosomal recessive gene.

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Inheritance of hyperbilirubinemia: Evidence for a major autosomal recessive gene

Digestive and Liver Disease ◽

10.1016/j.dld.2006.12.019 ◽

2007 ◽

Vol 39 (4) ◽

pp. 351-355 ◽

Cited By ~ 15

Author(s):

M. Clementi ◽

E. Di Gianantonio ◽

L. Fabris ◽

P. Forabosco ◽

M. Strazzabosco ◽

...

Keyword(s):

Autosomal Recessive ◽

Recessive Gene ◽

Autosomal Recessive Gene

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Muted, a new mutant affecting coat colour and otoliths of the mouse, and its position in linkage group XIV

Genetics Research ◽

10.1017/s0016672300002007 ◽

1969 ◽

Vol 14 (2) ◽

pp. 163-166 ◽

Cited By ~ 24

Author(s):

Mary F. Lyon ◽

R. Meredith

Keyword(s):

Linkage Group ◽

Autosomal Recessive ◽

Recessive Gene ◽

Coat Colour ◽

Group Xiv ◽

Eye Colour ◽

Autosomal Recessive Gene

The autosomal recessive gene muted, mu, which arose spontaneously, dilutes coat and eye colour and causes absence of otoliths in some but not all homozygotes. Its locus is in linkage group XIV of the mouse, and the order of loci was shown to be bg–Xt–sa–mu–f–pe.

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A lethal mutation (cab) affecting heart function in the mouse

Genetics Research ◽

10.1017/s0016672300018164 ◽

1979 ◽

Vol 33 (1) ◽

pp. 57-59 ◽

Cited By ~ 2

Author(s):

Francine B. Essien

Keyword(s):

Autosomal Recessive ◽

Heart Function ◽

Recessive Gene ◽

Lethal Mutation ◽

Significant Finding ◽

Cardiac Abnormality ◽

Autosomal Recessive Gene

SUMMARYA new autosomal recessive gene (cab, ‘cardiac abnormality’), which affects heart differentiation appeared spontaneously in our mouse colony. The affected homozygotes die approximately half a day prior to birth or at term, with the myocardium exhibiting vacuolation and large areas of mesenchyme-like cells. A significant finding in mutant foetuses is the lack of histochemically detectable glycogen.

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