Preparation of catalytic cellulose acetate and poly(vinyl alcohol) membranes doped with fine transition metal particles by a counter diffusion method

Herein, ciprofloxacin (CIP)-loaded alginate/poly (vinyl alcohol)/gelatin (SPG) (CIP–SPG) nanofiber mats were successfully fabricated by electrospinning. The average fiber diameters of the mats before and after crosslinking were in the range of 190–260 and 385–484 nm, respectively. The chemical integrity of CIP remained intact after encapsulation into the mats. The degree of weight loss and water swelling decreased with an increase in the gelatin content of the electrospun nanofiber mats. A release study was carried out by total immersion and diffusion methods using phosphate buffer as a release medium. Burst release of CIP was observed in case of the total immersion method, while a more sustained release was observed in case of the diffusion method. The maximum amounts of CIP released during total immersion and diffusion were in the range of 70–90% and 72–85%, respectively. For both the total immersion and diffusion methods, the released amounts of CIP decreased and the release slowed down with an increase in the gelatin content; this result is consistent with the weight loss and water swelling values. The Young’s modulus increased, while the tensile strength and strain at break decreased with an increase in the gelatin content. The CIP–SPG nanofiber mats were slightly toxic to L929 mouse fibroblasts as evaluated by indirect cytotoxicity assay. The electrospun CIP–SPG nanofiber mats exhibited excellent antimicrobial activity against Staphylococcus aureus and Escherichia coli. These results reveal that the electrospun CIP–SPG nanofiber mats are potentially promising materials for wound healing applications.

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Cellulose acetate/poly(vinyl alcohol) and cellulose acetate/crosslinked poly(vinyl alcohol) blend membranes: preparation, characterization, and antifouling properties

Desalination and Water Treatment ◽

10.1080/19443994.2015.1040846 ◽

2015 ◽

Vol 57 (23) ◽

pp. 10572-10584 ◽

Cited By ~ 20

Author(s):

Jun Yin ◽

Haijuan Fan ◽

Jiancheng Zhou

Keyword(s):

Cellulose Acetate ◽

Vinyl Alcohol ◽

Poly Vinyl Alcohol ◽

Blend Membranes

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Cellulose acetate/poly(vinyl alcohol) hybrid fibrous mat containing tetracycline hydrochloride and phenytoin sodium: Morphology, drug release, antibacterial, and cell culture studies

Journal of Bioactive and Compatible Polymers ◽

10.1177/0883911518779186 ◽

2018 ◽

Vol 33 (6) ◽

pp. 597-611 ◽

Cited By ~ 4

Author(s):

Hamed Souriyan-Reyhani pour ◽

Ramin Khajavi ◽

Mohammad Esmaeil Yazdanshenas ◽

Payam Zahedi ◽

Mohammad Mirjalili

Keyword(s):

Drug Release ◽

Cellulose Acetate ◽

Vinyl Alcohol ◽

Aqueous Media ◽

Tetracycline Hydrochloride ◽

Diameter Distribution ◽

Poly Vinyl Alcohol ◽

Release Kinetic ◽

Phenytoin Sodium ◽

20 Nm

The objective of this study was to introduce an electrospun hybrid fibrous mat (a dual-fiber drug delivery system) based on cellulose acetate and poly(vinyl alcohol) containing tetracycline hydrochloride and phenytoin sodium, respectively. Characterization of samples was carried by morphology, drug release, cell cytotoxicity, adhesion, antibacterial property, and wettability investigations. The results showed a uniform shape and a narrow diameter distribution of fibers (between 160 ± 20 nm) for fabricated cellulose acetate/poly(vinyl alcohol) hybrid fibrous mat. The tetracycline hydrochloride release from cellulose acetate significantly decreased due to gel formation of poly(vinyl alcohol) in aqueous media. The best fit for drug release kinetic of hybrid sample was Higuchi model. Sample with tetracycline hydrochloride and phenytoin sodium drugs showed improved cell growth, viability, and antibacterial activity against Escherichia coli (~89%) and Staphylococcus aureus (~98%) in comparison with sample without drugs. The hydrophilic property of cellulose acetate/poly(vinyl alcohol) fibrous sample containing the drugs was also remarkable (~45°). To consider the obtained results, the presented hybrid fibrous mat shows a high potent for biomedical applications.

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