Effect of roxithromycin on neutrophil reactive oxygen species: Another possible mechanism of action in acne

1993 ◽  
Vol 6 (1) ◽  
pp. 80
Author(s):  
Hirohiko Akamatsu ◽  
Setsuko Nishijima ◽  
Hiroko Sasaki ◽  
Yukie Niwa ◽  
Yasuo Asada
Keyword(s):  
Reactive Oxygen Species ◽  
Mechanism Of Action ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals Mechanism of action of 5-arninosalicylic acid

1992 ◽  
Vol 1 (3) ◽  
pp. 151-165 ◽  
Author(s):  
N. A. Punchard ◽  
S. M. Greenfield ◽  
R. P. H. Thompson
Keyword(s):  
Rheumatoid Arthritis ◽  
Reactive Oxygen Species ◽  
Inflammatory Bowel Disease ◽  
Mechanism Of Action ◽  
Bowel Disease ◽  
Second Messengers ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Aminosalicylic Acid ◽  
Inflammatory Bowel

5-Aminosalicylic Acid (5-ASA) has been used for over 50 years in the treatment of inflammatory bowel disease in the pro-drug form sulphasalazine (SASP). SASP is also used to treat rheumatoid arthritis. However whether the therapeutic properties of SASP are due to the intact molecule, the 5-ASA or sulphapyridine components is unknown. Several mechanisms of action have been proposed for 5-ASA and SASP including interference in the metabolism of arachidonic acid to prostaglandins and leukotrienes, scavenging,of reactive oxygen species, effects on leucocyte function and production of cytokines. However, it is unlikely that the anti-inflammatory properties of SASP and 5-ASA are due to several different properties but more likely that a single property of 5-ASA explains the theraapeutic effects of 5-ASA and SASP. Reactive oxygen species (ROS) are involved in the metabolism of prostaglandins and leukotrienes and can act as second messengers, and so the scavenging of ROS may be the single mechanism of action of 5-ASA that gives rise to its antiinflammatory effects in both inflammatory bowel disease and rheumatoid arthritis.

scholarly journals Mechanism of Action of Phenethylisothiocyanate and Other Reactive Oxygen Species-Inducing Anticancer Agents

2014 ◽  
Vol 34 (13) ◽  
pp. 2382-2395 ◽  
Author(s):  
I. Jutooru ◽  
A. S. Guthrie ◽  
G. Chadalapaka ◽  
S. Pathi ◽  
K. Kim ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Mechanism Of Action ◽  
Anticancer Agents ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals Oral Efficacy of Apigenin against Cutaneous Leishmaniasis: Involvement of Reactive Oxygen Species and Autophagy as a Mechanism of Action

2016 ◽  
Vol 10 (2) ◽  
pp. e0004442 ◽  
Author(s):  
Fernanda Fonseca-Silva ◽  
Job D. F. Inacio ◽  
Marilene M. Canto-Cavalheiro ◽  
Rubem F. S. Menna-Barreto ◽  
Elmo E. Almeida-Amaral
Keyword(s):  
Reactive Oxygen Species ◽  
Cutaneous Leishmaniasis ◽  
Mechanism Of Action ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals Sulforaphane Impact on Reactive Oxygen Species (ROS) in Bladder Carcinoma

2021 ◽  
Vol 22 (11) ◽  
pp. 5938
Author(s):  
Hui Xie ◽  
Felix K.-H. Chun ◽  
Jochen Rutz ◽  
Roman A. Blaheta
Keyword(s):  
Reactive Oxygen Species ◽  
Bladder Cancer ◽  
Cancer Progression ◽  
Mechanism Of Action ◽  
Bladder Carcinoma ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Chemopreventive Agent ◽  
Oxidative Processes

Sulforaphane (SFN) is a natural glucosinolate found in cruciferous vegetables that acts as a chemopreventive agent, but its mechanism of action is not clear. Due to antioxidative mechanisms being thought central in preventing cancer progression, SFN could play a role in oxidative processes. Since redox imbalance with increased levels of reactive oxygen species (ROS) is involved in the initiation and progression of bladder cancer, this mechanism might be involved when chemoresistance occurs. This review summarizes current understanding regarding the influence of SFN on ROS and ROS-related pathways and appraises a possible role of SFN in bladder cancer treatment.

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