scholarly journals Mechanism of Action of Phenethylisothiocyanate and Other Reactive Oxygen Species-Inducing Anticancer Agents

2014 ◽  
Vol 34 (13) ◽  
pp. 2382-2395 ◽  
Author(s):  
I. Jutooru ◽  
A. S. Guthrie ◽  
G. Chadalapaka ◽  
S. Pathi ◽  
K. Kim ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Mechanism Of Action ◽  
Anticancer Agents ◽  
Reactive Oxygen ◽  
Oxygen Species

Effect of roxithromycin on neutrophil reactive oxygen species: Another possible mechanism of action in acne

1993 ◽  
Vol 6 (1) ◽  
pp. 80
Author(s):  
Hirohiko Akamatsu ◽  
Setsuko Nishijima ◽  
Hiroko Sasaki ◽  
Yukie Niwa ◽  
Yasuo Asada
Keyword(s):  
Reactive Oxygen Species ◽  
Mechanism Of Action ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals Conjugation of Natural Triterpenic Acids with Delocalized Lipophilic Cations: Selective Targeting Cancer Cell Mitochondria

2021 ◽  
Vol 11 (6) ◽  
pp. 470
Author(s):  
Anna Yu. Spivak ◽  
Darya A. Nedopekina ◽  
Rinat R. Gubaidullin ◽  
Mikhail V. Dubinin ◽  
Konstantin N. Belosludtsev
Keyword(s):  
Reactive Oxygen Species ◽  
Anticancer Agents ◽  
Energy Production ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Pentacyclic Triterpenoids ◽  
Cell Death Pathways ◽  
Selective Targeting ◽  
Triterpenic Acids ◽  
Distinguishing Features

Currently, a new line of research on mitochondria-targeted anticancer drugs is actively developing in the field of biomedicine and medicinal chemistry. The distinguishing features of this universal target for anticancer agents include presence of mitochondria in the overwhelming majority, if not all types of transformed cells, crucial importance of these cytoplasmic organelles in energy production, regulation of cell death pathways, as well as generation of reactive oxygen species and maintenance of calcium homeostasis. Hence, mitochondriotropic anticancer mitocan agents, acting through mitochondrial destabilization, have good prospects in cancer therapy. Available natural pentacyclic triterpenoids are considered promising scaffolds for development of new mitochondria-targeted anticancer agents. These secondary metabolites affect the mitochondria of tumor cells and initiate formation of reactive oxygen species. The present paper focuses on the latest research outcomes of synthesis and study of cytotoxic activity of conjugates of pentacyclic triterpenoids with some mitochondria-targeted cationic lipophilic molecules and highlights the advantages of applying them as novel mitocan agents compared to their prototype natural triterpenic acids.

scholarly journals Mechanism of action of 5-arninosalicylic acid

1992 ◽  
Vol 1 (3) ◽  
pp. 151-165 ◽  
Author(s):  
N. A. Punchard ◽  
S. M. Greenfield ◽  
R. P. H. Thompson
Keyword(s):  
Rheumatoid Arthritis ◽  
Reactive Oxygen Species ◽  
Inflammatory Bowel Disease ◽  
Mechanism Of Action ◽  
Bowel Disease ◽  
Second Messengers ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Aminosalicylic Acid ◽  
Inflammatory Bowel

5-Aminosalicylic Acid (5-ASA) has been used for over 50 years in the treatment of inflammatory bowel disease in the pro-drug form sulphasalazine (SASP). SASP is also used to treat rheumatoid arthritis. However whether the therapeutic properties of SASP are due to the intact molecule, the 5-ASA or sulphapyridine components is unknown. Several mechanisms of action have been proposed for 5-ASA and SASP including interference in the metabolism of arachidonic acid to prostaglandins and leukotrienes, scavenging,of reactive oxygen species, effects on leucocyte function and production of cytokines. However, it is unlikely that the anti-inflammatory properties of SASP and 5-ASA are due to several different properties but more likely that a single property of 5-ASA explains the theraapeutic effects of 5-ASA and SASP. Reactive oxygen species (ROS) are involved in the metabolism of prostaglandins and leukotrienes and can act as second messengers, and so the scavenging of ROS may be the single mechanism of action of 5-ASA that gives rise to its antiinflammatory effects in both inflammatory bowel disease and rheumatoid arthritis.

scholarly journals Unifying Mechanism for Nutrients as Anticancer Agents: Electron Transfer, Reactive Oxygen Species and Oxidative Stress

2017 ◽  
Vol 9 (8) ◽  
pp. 66 ◽  
Author(s):  
Peter Kovacic ◽  
Ratnasamy Somanathan
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Electron Transfer ◽  
Anticancer Agents ◽  
Mode Of Action ◽  
Recent Article ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Bactericidal Action ◽  
And Oxidative Stress

A recent article deals with various nutrients in relation to bactericidal action. The present article focuses on a unifying mode of action for the nutrients, namely, resveratrol, epigallocatechin, polyene-ß-carotene, polyene lycopene, piperine, curcumin, genistein, luteolin, sulforaphane and pomegranate extract. The mechanism is based on electron transfer, reactive oxygen species and oxidative stress, which comprises an extension of earlier reports involving agents. Most of the compounds are precursors of electron transfer quinones, whereas others fit into the polyene category. The nutrients are better known as antioxidants. The dichotomy is addressed.

scholarly journals Oral Efficacy of Apigenin against Cutaneous Leishmaniasis: Involvement of Reactive Oxygen Species and Autophagy as a Mechanism of Action

2016 ◽  
Vol 10 (2) ◽  
pp. e0004442 ◽  
Author(s):  
Fernanda Fonseca-Silva ◽  
Job D. F. Inacio ◽  
Marilene M. Canto-Cavalheiro ◽  
Rubem F. S. Menna-Barreto ◽  
Elmo E. Almeida-Amaral
Keyword(s):  
Reactive Oxygen Species ◽  
Cutaneous Leishmaniasis ◽  
Mechanism Of Action ◽  
Reactive Oxygen ◽  
Oxygen Species
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