Comparative efficacy of moclobemide and imipramine on anxiety features in major depression- a meta-analysis of double blind comparative studies against placebo

1996 ◽  
Vol 6 ◽  
pp. S4-80-S4-81
Author(s):  
Alexandra Delini-Stula ◽  
Anne Cameron ◽  
Jules Angst
Keyword(s):  
Major Depression ◽  
Comparative Studies ◽  
Meta Analysis ◽  
Comparative Efficacy ◽  
Double Blind

scholarly journals St John's wort for depression

2005 ◽  
Vol 186 (2) ◽  
pp. 99-107 ◽  
Author(s):  
Klaus Linde ◽  
Michael Berner ◽  
Matthias Egger ◽  
Cynthia Mulrow
Keyword(s):  
Major Depression ◽  
Depressive Disorders ◽  
Meta Analysis ◽  
Current Evidence ◽  
Controlled Trials ◽  
Clinical Effects ◽  
Double Blind ◽  
Beneficial Effects ◽  
St John’S Wort ◽  
St John's Wort

BackgroundExtracts of Hypericum perforatum (St John's wort) are widely used to treat depression. Evidence for its efficacy has been criticised on methodological grounds.AimsTo update evidence from randomised trials regarding the effectiveness of Hypericum extracts.MethodsWe performed a systematic review and meta-analysis of 37 double-blind randomised controlled trials that compared clinical effects of Hypericum monopreparation with either placebo or a standard antidepressant in adults with depressive disorders.ResultsLarger placebo-controlled trials restricted to patients with major depression showed only minor effects over placebo, while older and smaller trials not restricted to patients with major depression showed marked effects. Compared with standard antidepressants Hypericum extracts had similar effects.ConclusionsCurrent evidence regarding Hypericum extracts is inconsistent and confusing. In patients who meet criteria for major depression, several recent placebo-controlled trials suggest that Hypericum has minimal beneficial effects while other trials suggest that Hypericum and standard antidepressants have similar beneficial effects.

scholarly journals Comparative efficacy and acceptability of first-generation and second-generation antidepressants in the acute treatment of major depression: protocol for a network meta-analysis

BMJ Open ◽  
2016 ◽  
Vol 6 (7) ◽  
pp. e010919 ◽  
Author(s):  
Toshi A Furukawa ◽  
Georgia Salanti ◽  
Lauren Z Atkinson ◽  
Stefan Leucht ◽  
Henricus G Ruhe ◽  
...  
Keyword(s):  
Major Depression ◽  
Acute Treatment ◽  
First Generation ◽  
Second Generation ◽  
Meta Analysis ◽  
Comparative Efficacy
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