Growth inhibition of oestrogen receptor-positive human ovarian carcinoma by anti-oestrogens in vitro and in a xenograft model

1994 ◽  
Vol 30 (5) ◽  
pp. 682-686 ◽  
Author(s):  
S.P. Langdon ◽  
A.J. Crew ◽  
A.A. Ritchie ◽  
M. Muir ◽  
A. Wakeling ◽  
...  
Keyword(s):  
Growth Inhibition ◽  
Ovarian Carcinoma ◽  
Oestrogen Receptor ◽  
Xenograft Model ◽  
Human Ovarian Carcinoma

Inhibitory Effects of Natural Food Dyes Genistein on Invasion of SKOV3 Human Ovarian Carcinoma Cells In Vivo and In Vitro

2013 ◽  
Vol 781-784 ◽  
pp. 1152-1155
Author(s):  
Tang Li ◽  
Li Yu
Keyword(s):  
Ovarian Carcinoma ◽  
Carcinoma Cell ◽  
Treated Group ◽  
Ovarian Cancer Cells ◽  
Natural Food ◽  
Ovarian Carcinoma Cell Line ◽  
Skov3 Cells ◽  
Human Ovarian Carcinoma

The invasion behavior of tumor cells is important in the metastasis process of ovarian cancer cells. In this study we investigated the effects of Genistein on invasion inhibition in ovarian carcinoma cell line SKOV3 in vivo and in vitro. The abilities of the Genistein-treated SKOV3 cells to invade through reconstitute matrigel in transwell chambers were investigated in vitro and the invasion effect in vivo was determined by using the xenograft models of SKOV3 in nude mice. The ability of the 20μmol/L Genistein-treated cells to invade the reconstitute basement membrane was decreased significantly at 72h. This inhibition was dose-dependent. 40μmol/L Genistein had the strongest effect. The in vivo result suggested that the grade of invasion in control SKOV3 cells was time-dependent and Genistein-treated group could apparently inhibit the progress of invasion, localizing the tumor in invasion Grade 0 or Grade I and decreasing the proportion of Grade II, III and IV. The results suggested that Genistein possessed inhibitory effect on invasion in human ovarian carcinoma cell lines SKOV3 in vivo and in vitro.

scholarly journals The HDACi Panobinostat Shows Growth Inhibition Both In Vitro and in a Bioluminescent Orthotopic Surgical Xenograft Model of Ovarian Cancer

PLoS ONE ◽  
2016 ◽  
Vol 11 (6) ◽  
pp. e0158208 ◽  
Author(s):  
Øystein Helland ◽  
Mihaela Popa ◽  
Katharina Bischof ◽  
Bjørn Tore Gjertsen ◽  
Emmet McCormack ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Growth Inhibition ◽  
Xenograft Model

scholarly journals Immunoliposome-mediated targeting of doxorubicin to human ovarian carcinoma in vitro and in vivo

1996 ◽  
Vol 74 (7) ◽  
pp. 1023-1029 ◽  
Author(s):  
MH Vingerhoeds ◽  
PA Steerenberg ◽  
JJGW Hendriks ◽  
LC Dekker ◽  
QGCM Van Hoesel ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Human Ovarian Carcinoma

scholarly journals Characterization of a xenograft model of human ovarian carcinoma which produces intraperitoneal carcinomatosis and metastases in mice

1996 ◽  
Vol 68 (5) ◽  
pp. 588-595 ◽  
Author(s):  
Kelly L. Molpus ◽  
Daniel Koelliker ◽  
Leonard Atkins ◽  
Daniel T. Kato ◽  
Joanne Buczek-Thomas ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Xenograft Model ◽  
Human Ovarian Carcinoma
Sign in / Sign up

Export Citation Format

Share Document