THE COPARATIVE STUDY OF MECHANISM OF INSULIN ACTION ON MUSCLE CARBOHYDRATE METABOLISM

1976 ◽  
pp. 345-362 ◽  
Author(s):  
L. Leibson ◽  
Erica Plisetskaya ◽  
B. Leibush
Keyword(s):  
Carbohydrate Metabolism ◽  
Insulin Action

scholarly journals Defects of Insulin Action on Fatty Acid and Carbohydrate Metabolism in Familial Combined Hyperlipidemia

1997 ◽  
Vol 17 (4) ◽  
pp. 748-754 ◽  
Author(s):  
Timothy J. Aitman ◽  
Ian F. Godsland ◽  
Bernadette Farren ◽  
David Crook ◽  
H. John Wong ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Carbohydrate Metabolism ◽  
Insulin Action ◽  
Familial Combined Hyperlipidemia

scholarly journals Assessment of insulin action on carbohydrate metabolism: physiological and non-physiological methods

2013 ◽  
Vol 30 (6) ◽  
pp. 664-670 ◽  
Author(s):  
S. Dube ◽  
I. Errazuriz ◽  
C. Cobelli ◽  
R. Basu ◽  
A. Basu
Keyword(s):  
Carbohydrate Metabolism ◽  
Insulin Action

Sites of Insulin Action Using Ferritin Labeling

1971 ◽  
Vol 29 ◽  
pp. 540-541
Author(s):  
Burton B. Silver ◽  
Ronald S. Nelson
Keyword(s):  
Electron Microscopy ◽  
Binding Sites ◽  
Anterior Pituitary ◽  
Insulin Action ◽  
Diabetic Rats ◽  
Insulin Antibody ◽  
Fat Pad ◽  
Target Organs ◽  
Uranium Salts ◽  
Sugar Levels

Some investigators feel that insulin does not enter cells but exerts its influence in some manner on the cell surface. Ferritin labeling of insulin and insulin antibody was used to determine if binding sites of insulin to specific target organs could be seen with electron microscopy.Alloxanized rats were considered diabetic if blood sugar levels were in excess of 300 mg %. Test reagents included ferritin, ferritin labeled insulin, and ferritin labeled insulin antibody. Target organs examined were were diaphragm, kidney, gastrocnemius, fat pad, liver and anterior pituitary. Reagents were administered through the left common carotid. Survival time was at least one hour in test animals. Tissue incubation studies were also done in normal as well as diabetic rats. Specimens were fixed in gluteraldehyde and osmium followed by staining with lead and uranium salts. Some tissues were not stained.

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