APPLICATIONS OF STABLE ISOTOPE LABELLING IN STUDIES OF THE PHARMACOKINETICS AND METABOLISM OF CLONIDINE

Abstracts ◽  
1978 ◽  
pp. 716
Author(s):  
D S Davies ◽  
T A Baillie ◽  
E Neill ◽  
H Hughes ◽  
D L Davies
Keyword(s):  
Stable Isotope ◽  
Stable Isotope Labelling ◽  
Isotope Labelling

Dynamic lipidomics with stable isotope labelling

2009 ◽  
Vol 877 (26) ◽  
pp. 2716-2721 ◽  
Author(s):  
Anthony D. Postle ◽  
Alan N. Hunt
Keyword(s):  
Stable Isotope ◽  
Stable Isotope Labelling ◽  
Isotope Labelling

scholarly journals Stable isotope labelling in vivo as an aid to protein identification in peptide mass fingerprinting

PROTEOMICS ◽  
2002 ◽  
Vol 2 (2) ◽  
pp. 157-163 ◽  
Author(s):  
Julie M. Pratt ◽  
Duncan H. L. Robertson ◽  
Simon J. Gaskell ◽  
Isabel Riba-Garcia ◽  
Simon J. Hubbard ◽  
...  
Keyword(s):  
Stable Isotope ◽  
Protein Identification ◽  
Peptide Mass Fingerprinting ◽  
Stable Isotope Labelling ◽  
Isotope Labelling ◽  
Peptide Mass

scholarly journals The contributions of biosynthesis and acyl chain remodelling to the molecular species profile of phosphatidylcholine in yeast

2005 ◽  
Vol 33 (5) ◽  
pp. 1146-1149 ◽  
Author(s):  
H.A. Boumann ◽  
A.I.P.M. de Kroon
Keyword(s):  
Stable Isotope ◽  
Species Composition ◽  
Molecular Species ◽  
Acyl Chain ◽  
Membrane Lipid ◽  
Molecular Species Composition ◽  
Stable Isotope Labelling ◽  
Membrane Function ◽  
Isotope Labelling ◽  
Acyl Chains

Phosphatidylcholine (PC) is a very abundant membrane lipid in most eukaryotes, including yeast. The molecular species profile of PC, i.e. the ensemble of PC molecules with acyl chains differing in number of carbon atoms and double bonds, is important for membrane function. Pathways of PC synthesis and turnover maintain PC homoeostasis and determine the molecular species profile of PC. Studies addressing the processes involved in establishing the molecular species composition of PC in yeast using stable isotope labelling combined with detection by MS are reviewed.

scholarly journals Stable isotope labelling: an approach for MALDI-TOF MS-based rapid detection of fluconazole resistance in Candida tropicalis

2019 ◽  
Vol 74 (5) ◽  
pp. 1269-1276 ◽  
Author(s):  
Saikat Paul ◽  
Shreya Singh ◽  
Arunaloke Chakrabarti ◽  
Shivaprakash M Rudramurthy ◽  
Anup K Ghosh
Keyword(s):  
Stable Isotope ◽  
Candida Tropicalis ◽  
Rapid Detection ◽  
Stable Isotope Labelling ◽  
Fluconazole Resistance ◽  
Isotope Labelling ◽  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Tof Ms

scholarly journals Analytical Considerations of Stable Isotope Labelling in Lipidomics

Biomolecules ◽  
2018 ◽  
Vol 8 (4) ◽  
pp. 151 ◽  
Author(s):  
Alexander Triebl ◽  
Markus Wenk
Keyword(s):  
Mass Spectrometry ◽  
Stable Isotope ◽  
Clinical Settings ◽  
Stable Isotope Labelling ◽  
Stable Isotope Label ◽  
Isotope Labelling ◽  
Isotope Label ◽  
Lipid Biomarker ◽  
Staple Technique ◽  
Biomarker Research

Over the last two decades, lipids have come to be understood as far more than merely components of cellular membranes and forms of energy storage, and are now also being implicated to play important roles in a variety of diseases, with lipid biomarker research one of the most widespread applications of lipidomic techniques both in research and in clinical settings. Stable isotope labelling has become a staple technique in the analysis of small molecule metabolism and dynamics, as it is the only experimental setup by which biosynthesis, remodelling and degradation of biomolecules can be directly measured. Using state-of-the-art analytical technologies such as chromatography-coupled high resolution tandem mass spectrometry, the stable isotope label can be precisely localized and quantified within the biomolecules. The application of stable isotope labelling to lipidomics is however complicated by the diversity of lipids and the complexity of the necessary data analysis. This article discusses key experimental aspects of stable isotope labelling in the field of mass spectrometry-based lipidomics, summarizes current applications and provides an outlook on future developments and potential.

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