BROWN FAT THERMOREGULATION IN DEVELOPING AND COLD ADAPTED RATS AND HAMSTERS

Author(s):  
U. Sundin ◽  
D. Herron ◽  
B. Cannon
Keyword(s):  
1976 ◽  
Vol 50 (1) ◽  
pp. 47-55 ◽  
Author(s):  
M. Pavelka ◽  
H. Goldenberg ◽  
M. H�ttinger ◽  
R. Kramar

1985 ◽  
Vol 69 (3) ◽  
pp. 343-348 ◽  
Author(s):  
S. Cunningham ◽  
P. Leslie ◽  
D. Hopwood ◽  
P. Illingworth ◽  
R. T. Jung ◽  
...  

1. In adult man, brown fat can be detected in perinephric fat depots by visual inspection, electron microscopy and nucleotide binding to the tissue-specific uncoupling protein. 2. The 32 kDa uncoupling protein is functionally active, showing a nucleotide-sensitive conductance to protons and an uncoupling response to fatty acids. 3. The amount of uncoupling protein in human mitochondria is equivalent to that in a partially cold-adapted guinea pig, indicating some potential for thermogenesis. 4. Respiratory capacity measurements indicate that the total perinephric fat in adult man can only account for one-fivehundredth of the whole-body response to infused noradrenaline. Thus, although brown fat has been found to be quantitatively important in animal studies, considerable caution must be exercised in extrapolating its significance to adult man.


1981 ◽  
Vol 59 (4) ◽  
pp. 351-354 ◽  
Author(s):  
P. Hahn ◽  
C. Laury ◽  
R. Portet

Cold-adapted (CA) and warm-adapted (WA) rats (5 and 28 °C) were infused with noradrenaline (4 μg∙kg−1∙min−1) for 15 min. Blood was collected from Sulzer's vein coming from brown adipose tissue and analyzed for total carnitine, free carnitine, and β-hydroxybutyrate content, before and up to 45 min after the infusion. Acylcarnitine (total minus free carnitine) levels increased more and total carnitine levels decreased more in the CA group than in the WA group. β-Hydroxybutyrate content increased to the same extent (from about 0.16 to 0.8 mM) in both groups. Brown fat was found not to release carnitine into the circulation after NA infusion. Twenty minutes after the end of infusion brown fat retained both ketones and acylcarnitine in the CA rats only.


2006 ◽  
Vol 40 (11) ◽  
pp. 8
Author(s):  
MIRIAM E. TUCKER
Keyword(s):  

2019 ◽  
Vol 25 ◽  
pp. 293-294
Author(s):  
Priya Jaisinghani ◽  
Sara Lubitz ◽  
David Cohen
Keyword(s):  

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 274-OR ◽  
Author(s):  
GUOXIAO WANG ◽  
JESSE G. MEYER ◽  
WEIKANG CAI ◽  
MENGYAO E. LI ◽  
SAMIR SOFTIC ◽  
...  

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1897-P
Author(s):  
HISASHI YOKOMIZO ◽  
ATSUSHI ISHIKADO ◽  
TAKANORI SHINJO ◽  
KYOUNGMIN PARK ◽  
YASUTAKA MAEDA ◽  
...  

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