Synthetic Approaches to Incorporation of Novel Amino Acids into Gonadotropin-Releasing Hormone Peptides

1993 ◽  
pp. 3-18
Author(s):  
Fortuna Haviv ◽  
Timothy D. Fitzpatrick
Keyword(s):  
Amino Acids ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Synthetic Approaches

Gonadotropin-releasing hormone antagonists containing novel amino acids

Peptides ◽  
1994 ◽  
pp. 403-405
Author(s):  
G.-C. Jiang ◽  
J. Porter ◽  
C. Rivier ◽  
A. Corrigan ◽  
W. Vale ◽  
...  
Keyword(s):  
Amino Acids ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Gonadotropin Releasing Hormone Antagonists ◽  
Hormone Antagonists

Excitatory Amino Acids Act on the Median Eminence Nerve Terminals to Induce Gonadotropin-Releasing Hormone Release in Female Rats

1998 ◽  
Vol 112 (3) ◽  
pp. 372-382 ◽  
Author(s):  
Shin-ichi Kawakami ◽  
Masumi Ichikawa ◽  
Kumiko Murahashi ◽  
Kanjun Hirunagi ◽  
Hiroko Tsukamura ◽  
...  
Keyword(s):  
Amino Acids ◽  
Median Eminence ◽  
Excitatory Amino Acids ◽  
Gonadotropin Releasing Hormone ◽  
Female Rats ◽  
Nerve Terminals ◽  
Hormone Release ◽  
Releasing Hormone

Expedient Synthesis of Gonadotropin Releasing Hormone (GnRH) Through a Combined Chemical-Enzymatic Approach

1992 ◽  
Vol 47 (10) ◽  
pp. 1424-1430
Author(s):  
Urszula Słomczyńska ◽  
Tomasz Leplawy ◽  
Mirosław T. Leplawy
Keyword(s):  
Amino Acids ◽  
Scaling Up ◽  
Gonadotropin Releasing Hormone ◽  
Synthetic Approach ◽  
Side Chains ◽  
Chemical Methods ◽  
Peptide Bonds ◽  
Releasing Hormone ◽  
Protection Strategy

We have developed a chemical-enzymatic synthetic approach to gonadotropin releasing hormone Glp1–His-2–Trp3–Ser4–Tyr5–Gly6–Leu7–Arg8—Pro9–Gly10–NH2 (GnRH) which enables one to perform the synthesis efficiently according to minimal protection strategy with all reactive side chains of amino acids unprotected. Five peptide bonds His2–Trp3, Tyr5–Gly6, Leu7–Arg8 and Trp3–Ser4, Ser4–Tyr5 were formed by means of a-chymotrypsin and papain, respectively. The remaining four bonds Glp1–His2, Gly6–Leu7, Arg8—Pro9, Pro9—Gly10 were formed by chemical methods. The synthesis is simple to carry out and there are no problems in scaling up as demonstrated by the final coupling on 2 g scale affording highly pure GnRH in the yield of 84-90%.

186: Neoadjuvant Gonadotropin-Releasing Hormone Therapy Before Orchiopexy Improves the Fertility Index in Concomitant Testicular Biopsies

2004 ◽  
Vol 171 (4S) ◽  
pp. 49-49
Author(s):  
Christian Schwentner ◽  
Andreas Lunacek ◽  
Josef Oswald ◽  
Georg Bartsch ◽  
Alfons Kreczy ◽  
...  
Keyword(s):  
Hormone Therapy ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Fertility Index
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