Poly(ADP-ribose) and the Differentiation of Embryonic Tissue

1982 ◽  
pp. 389-405 ◽  
Author(s):  
BARRY W. CHERNEY ◽  
RONALD J. MIDURA ◽  
ARNOLD I. CAPLAN
Keyword(s):  
Embryonic Tissue

Biochemical studies on the nucleic acid metabolism of embryonic tissue and the effect of drugs

1968 ◽  
Vol 259 (2) ◽  
pp. 186-188 ◽  
Author(s):  
D. Neubert ◽  
E. Oberdisse ◽  
H.-J. Merker ◽  
E. K�hler ◽  
B.-R. Balda
Keyword(s):  
Nucleic Acid ◽  
Acid Metabolism ◽  
Embryonic Tissue ◽  
Nucleic Acid Metabolism ◽  
Biochemical Studies

Viral Susceptibility and Embryonic Differentiation.

Development ◽  
1963 ◽  
Vol 11 (4) ◽  
pp. 757-764
Author(s):  
Juhani Rapola ◽  
Tapani Vainio ◽  
Lauri Saxén
Keyword(s):  
Tissue Culture ◽  
Viral Replication ◽  
Metabolic Rate ◽  
Tissue Damage ◽  
Embryonic Tissue ◽  
High Metabolic Rate ◽  
Viral Susceptibility ◽  
Proliferative Rate ◽  
Active Proliferation ◽  
Severe Tissue

The fact that viral susceptibility changes during embryogenesis has been pointed out by both experimental embryologists and clinical practitioners, not to mention virologists working with avian material. In attempts to find the fundamental factors which make embryonic tissue susceptible or resistant to a given virus, the metabolic and proliferative rate have been considered relevant (Williamson et al., 1953; Robertson et al., 1955; Töndury, 1956). Experience accumulated in studies of the replication of various viruses in tissue culture has taught us that a high metabolic rate and active proliferation may not always enhance viral replication (Ginsberg, 1958). However, there seems to be justification for the view that an injurious agent leads to more severe tissue damage when it exercises its effect upon actively proliferating tissues than when it does so at the ‘resting stage’.

Inhibition of pulmonary tumour development in rats sensitised to rat embryonic tissue

Nature ◽  
1975 ◽  
Vol 255 (5506) ◽  
pp. 329-330 ◽  
Author(s):  
R. C. REES ◽  
L. P. SHAH ◽  
R. W. BALDWIN
Keyword(s):  
Embryonic Tissue ◽  
Tumour Development

scholarly journals STUDIES ON THE INACTIVATION OF VACCINE VIRUS AND THE ACTION OF CERTAIN SUBSTANCES UPON THE INFECTING POWER OF THE INACTIVATED VIRUS

1928 ◽  
Vol 47 (3) ◽  
pp. 389-402 ◽  
Author(s):  
F. Duran Reynals
Keyword(s):  
Vaccine Virus ◽  
Embryonic Tissue ◽  
Tissue Cultures ◽  
Supernatant Fluid ◽  
High Susceptibility

Vaccine virus, obtained from testicular inoculation shows a high susceptibility to chloroform as compared with ether, toluene, 95 per cent alcohol and acetone. Vaccine virus, after treatment with an amount of chloroform sufficient to render it incapable or only barely capable of originating an eruption in the rabbit's skin, produces a characteristic eruption when injected with the supernatant fluid of embryonic tissue or sarcoma tissue "cultures" or kieselguhr, substances all of which are markedly irritative to the rabbit's skin. Reactivation of the chloroformed vaccine virus is not possible when chloroform has been added to it in such quantity that the injection of large amounts of the treated virus fails to cause an eruption. Whenever reactivation has been accomplished it has been possible to get a vaccine eruption of greater or less intensity by the injection of large amounts of the chloroformed vaccine alone. Embryo and chicken sarcoma "culture" fluids when injected intradermally make the skin susceptible to the localization of the virus introduced intravenously. The bearing of these experiment on the interpretation of Gye' theory of cancer causation is discussed.

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