Non-specific Hydroxyl Radical Scavenging Properties of Melanoidins from Beer

Author(s):  
Francisco J. Morales
Author(s):  
Nguyen Minh Thong Nguyen

- A density functional theory (DFT) study on the hydroxyl radical scavenging properties of Kinsenoside originated from Anoectochilus roxburghii is presented. Two mechanisms, single electron transfer (SET) and hydrogen atom transfer (HAT) are considered. The thermochemical results demonstrate that the SET mechanism is not plausible to occur. With respect to the HAT, the interaction of OH• radical with Kinsenoside is also studied in detail by establishing potential energy surface (PES). This result strongly confirms that the C8H bond decides the radical scavenging activity of Kinsenoside with activation Gibbs free energy (∆G≠) and rate constants (k) of 1.1 kcal/mol and 5.9×10-8 cm3/molecules, respectively


Author(s):  
Birgit Orthen ◽  
Marianne Popp ◽  
Nicholas Smirnoff

Cyclitols are low molecular weight substances which accumulate in plant cells in response to various environmental stress situations, for example drought (Ford 1984), salinity (Gorham et al. 1984), low temperature (Richter et al. 1990).Apart from their more general role in osmotic adjustment, only in the case of salt stress is their mode of function well understood. Cyclitols (e.g. pinitol) accumulate when plants are exposed to increasing salt concentration (Paul & Cockburn 1989) and act as compatible solutes (Sommer et al. 1990) as defined by Brown & Simpson (1972).The significance of cyclitol accumulation in stress adaptation of plants to drought and cold still remains uncertain. However, it is generally accepted that drought and cold as well as several other stress situations lead to an enhanced generation of oxygen free radicals (Elstner 1990; Smirnoff & Colombe 1988), including the hydroxyl radical as the most harmful one. The report by Smirnoff & Cumbes (1989) that myo-inositol is an effective hydroxyl radical scavenger prompted us to test other naturally-occuring cyclitols like pinitol, quebrachitol, 1-D-1-O-methyl-muco-inositol, ononitol and quercitol for their ability to scavenge hydroxyl radicals.


IUBMB Life ◽  
1997 ◽  
Vol 42 (6) ◽  
pp. 1249-1260 ◽  
Author(s):  
Theodore Macrides ◽  
Amal Shihata ◽  
Nicolette Kalafatis ◽  
Paul Wright

2019 ◽  
Vol 26 (39) ◽  
pp. 6976-6990 ◽  
Author(s):  
Ana María González-Paramás ◽  
Begoña Ayuda-Durán ◽  
Sofía Martínez ◽  
Susana González-Manzano ◽  
Celestino Santos-Buelga

: Flavonoids are phenolic compounds widely distributed in the human diet. Their intake has been associated with a decreased risk of different diseases such as cancer, immune dysfunction or coronary heart disease. However, the knowledge about the mechanisms behind their in vivo activity is limited and still under discussion. For years, their bioactivity was associated with the direct antioxidant and radical scavenging properties of phenolic compounds, but nowadays this assumption is unlikely to explain their putative health effects, or at least to be the only explanation for them. New hypotheses about possible mechanisms have been postulated, including the influence of the interaction of polyphenols and gut microbiota and also the possibility that flavonoids or their metabolites could modify gene expression or act as potential modulators of intracellular signaling cascades. This paper reviews all these topics, from the classical view as antioxidants in the context of the Oxidative Stress theory to the most recent tendencies related with the modulation of redox signaling pathways, modification of gene expression or interactions with the intestinal microbiota. The use of C. elegans as a model organism for the study of the molecular mechanisms involved in biological activity of flavonoids is also discussed.


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