Faculty Opinions recommendation of The Dps protein of Agrobacterium tumefaciens does not bind to DNA but protects it toward oxidative cleavage: x-ray crystal structure, iron binding, and hydroxyl-radical scavenging properties.

2003 ◽  
Author(s):  
Elizabeth Theil
Keyword(s):  
Crystal Structure ◽  
Agrobacterium Tumefaciens ◽  
Hydroxyl Radical ◽  
Radical Scavenging ◽  
Oxidative Cleavage ◽  
Iron Binding ◽  
X Ray ◽  
Radical Scavenging Properties ◽  
Dps Protein

scholarly journals Scavenging of hydroxyl radical by kinsenoside originated from anoectochilus roxburghii: A DFT approach

2020 ◽  
pp. 72-76
Author(s):  
Nguyen Minh Thong Nguyen
Keyword(s):  
Hydroxyl Radical ◽  
Density Functional ◽  
Energy Surface ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Hydrogen Atom Transfer ◽  
Single Electron Transfer ◽  
Functional Theory ◽  
Anoectochilus Roxburghii ◽  
Radical Scavenging Properties

- A density functional theory (DFT) study on the hydroxyl radical scavenging properties of Kinsenoside originated from Anoectochilus roxburghii is presented. Two mechanisms, single electron transfer (SET) and hydrogen atom transfer (HAT) are considered. The thermochemical results demonstrate that the SET mechanism is not plausible to occur. With respect to the HAT, the interaction of OH• radical with Kinsenoside is also studied in detail by establishing potential energy surface (PES). This result strongly confirms that the C8H bond decides the radical scavenging activity of Kinsenoside with activation Gibbs free energy (∆G≠) and rate constants (k) of 1.1 kcal/mol and 5.9×10-8 cm3/molecules, respectively

scholarly journals Substituted 4-Acyl-5-methyl-2-phenyl-pyrazol-3-one-phenylhydrazones with Antioxidant Properties: X-Ray Crystal and Spectroscopic Studies

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Omoruyi G. Idemudia ◽  
Anthony I. Okoh ◽  
Alexander P. Sadimenko ◽  
Eric C. Hosten ◽  
Omobola O. Okoh
Keyword(s):  
Free Radical ◽  
Schiff Bases ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Spectroscopic Studies ◽  
Free Radical Scavenging ◽  
X Ray ◽  
X Ray Crystallography ◽  
H Nmr ◽  
Radical Scavenging Properties

Phenylhydrazine was reacted with synthesized acylpyrazolone derivatives 4-ethyl-5-methyl-2-phenyl-pyrazol-3-one and 4-propyl-5-methyl-2-phenyl-pyrazol-3-one, to obtain two new azomethine phenylhydrazones, a study in continuation of our probe into the effects of acyl group substitutions on the physicochemical and free radical scavenging properties of acylpyrazolone Schiff bases. The keto imine tautomers of 4-ethyl-5-methyl-2-phenyl-pyrazol-3-one-phenylhydrazone (Empp-Ph) and 4-propyl-5-methyl-2-phenyl-pyrazol-3-one-phenylhydrazone (Prmpp-Ph) according to single X-ray crystallography data which precipitated in good yield are reported. Furthermore they have been characterized by elemental analysis, FTIR, 13C and 1H NMR, and mass-spectroscopy techniques. Both phenylhydrazone Schiff bases crystallize in a triclinic crystal system, each with a space group of P-1 (number 2) having short intramolecular N3—H3…O1 hydrogen interaction between the first hydrazine hydrogen H3 and the pyrazolone oxygen O1. The antioxidant free radical scavenging activities of titled compounds against 2,2-diphenyl-1-picrylhydrazyl (DPPH) showed a positive response almost as good as that of vitamin c under the same conditions, with the propyl substituted 4-propyl-5-methyl-2-phenyl-pyrazol-3-one-phenylhydrazone (Prmpp-Ph) having a stronger activity (calculated IC50 value of 175.66 μg/ml).

Hydroxyl radical scavenging properties of cyclitols

1994 ◽  
Vol 102 ◽  
pp. 269-272 ◽  
Author(s):  
Birgit Orthen ◽  
Marianne Popp ◽  
Nicholas Smirnoff
Keyword(s):  
Hydroxyl Radical ◽  
Oxygen Free Radicals ◽  
Radical Scavenging ◽  
Compatible Solutes ◽  
Plant Cells ◽  
Radical Scavenger ◽  
Low Molecular Weight ◽  
General Role ◽  
Hydroxyl Radical Scavenger ◽  
Radical Scavenging Properties

Cyclitols are low molecular weight substances which accumulate in plant cells in response to various environmental stress situations, for example drought (Ford 1984), salinity (Gorham et al. 1984), low temperature (Richter et al. 1990).Apart from their more general role in osmotic adjustment, only in the case of salt stress is their mode of function well understood. Cyclitols (e.g. pinitol) accumulate when plants are exposed to increasing salt concentration (Paul & Cockburn 1989) and act as compatible solutes (Sommer et al. 1990) as defined by Brown & Simpson (1972).The significance of cyclitol accumulation in stress adaptation of plants to drought and cold still remains uncertain. However, it is generally accepted that drought and cold as well as several other stress situations lead to an enhanced generation of oxygen free radicals (Elstner 1990; Smirnoff & Colombe 1988), including the hydroxyl radical as the most harmful one. The report by Smirnoff & Cumbes (1989) that myo-inositol is an effective hydroxyl radical scavenger prompted us to test other naturally-occuring cyclitols like pinitol, quebrachitol, 1-D-1-O-methyl-muco-inositol, ononitol and quercitol for their ability to scavenge hydroxyl radicals.

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