Conception, Implementation and Operation of Large-Scale Metabolic Phenotyping Centres: Phenome Centres

2019 ◽  
pp. 385-405 ◽  
Author(s):  
Frank W. Bonner ◽  
Lynn Maslen ◽  
John C. Lindon ◽  
Matthew R. Lewis ◽  
Jeremy K. Nicholson
Keyword(s):  
Large Scale ◽  
Metabolic Phenotyping

High-Throughput Microbore UPLC–MS Metabolic Phenotyping of Urine for Large-Scale Epidemiology Studies

2015 ◽  
Vol 14 (6) ◽  
pp. 2714-2721 ◽  
Author(s):  
Nicola Gray ◽  
Matthew R. Lewis ◽  
Robert S. Plumb ◽  
Ian D. Wilson ◽  
Jeremy K. Nicholson
Keyword(s):  
High Throughput ◽  
Large Scale ◽  
Metabolic Phenotyping ◽  
Epidemiology Studies

scholarly journals The nPYc-Toolbox, a Python module for the pre-processing, quality-control and analysis of metabolic profiling datasets

2019 ◽  
Vol 35 (24) ◽  
pp. 5359-5360 ◽  
Author(s):  
Caroline J Sands ◽  
Arnaud M Wolfer ◽  
Gonçalo D S Correia ◽  
Noureddin Sadawi ◽  
Arfan Ahmed ◽  
...  
Keyword(s):  
Quality Control ◽  
Statistical Analysis ◽  
Metabolic Profiling ◽  
Large Scale ◽  
Analytical Data ◽  
Processing Quality ◽  
Metabolic Phenotyping ◽  
Python Package

Abstract Summary As large-scale metabolic phenotyping studies become increasingly common, the need for systemic methods for pre-processing and quality control (QC) of analytical data prior to statistical analysis has become increasingly important, both within a study, and to allow meaningful inter-study comparisons. The nPYc-Toolbox provides software for the import, pre-processing, QC and visualization of metabolic phenotyping datasets, either interactively, or in automated pipelines. Availability and implementation The nPYc-Toolbox is implemented in Python, and is freely available from the Python package index https://pypi.org/project/nPYc/, source is available at https://github.com/phenomecentre/nPYc-Toolbox. Full documentation can be found at http://npyc-toolbox.readthedocs.io/ and exemplar datasets and tutorials at https://github.com/phenomecentre/nPYc-toolbox-tutorials.

Precision High-Throughput Proton NMR Spectroscopy of Human Urine, Serum, and Plasma for Large-Scale Metabolic Phenotyping

2014 ◽  
Vol 86 (19) ◽  
pp. 9887-9894 ◽  
Author(s):  
Anthony C. Dona ◽  
Beatriz Jiménez ◽  
Hartmut Schäfer ◽  
Eberhard Humpfer ◽  
Manfred Spraul ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
High Throughput ◽  
Human Urine ◽  
Large Scale ◽  
Proton Nmr ◽  
Proton Nmr Spectroscopy ◽  
Metabolic Phenotyping ◽  
Urine Serum

scholarly journals Large-Scale Human Metabolic Phenotyping and Molecular Epidemiological Studies via1H NMR Spectroscopy of Urine: Investigation of Borate Preservation

2009 ◽  
Vol 81 (12) ◽  
pp. 4847-4856 ◽  
Author(s):  
Leon M. Smith ◽  
Anthony D. Maher ◽  
Elizabeth J. Want ◽  
Paul Elliott ◽  
Jeremiah Stamler ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Large Scale ◽  
Epidemiological Studies ◽  
Metabolic Phenotyping

Large-scale population-based metabolic phenotyping of thirteen genetic polymorphisms related to one-carbon metabolism

2007 ◽  
Vol 28 (9) ◽  
pp. 856-865 ◽  
Author(s):  
Åse Fredriksen ◽  
Klaus Meyer ◽  
Per Magne Ueland ◽  
Stein Emil Vollset ◽  
Tom Grotmol ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Carbon Metabolism ◽  
Large Scale ◽  
Population Based ◽  
Metabolic Phenotyping ◽  
Scale Population ◽  
One Carbon Metabolism

scholarly journals J-Resolved 1H NMR 1D-Projections for Large-Scale Metabolic Phenotyping Studies: Application to Blood Plasma Analysis

2017 ◽  
Vol 89 (21) ◽  
pp. 11405-11412 ◽  
Author(s):  
Andrea Rodriguez-Martinez ◽  
Joram M. Posma ◽  
Rafael Ayala ◽  
Nikita Harvey ◽  
Beatriz Jimenez ◽  
...  
Keyword(s):  
Blood Plasma ◽  
1H Nmr ◽  
Large Scale ◽  
Plasma Analysis ◽  
Metabolic Phenotyping

scholarly journals Optimization and Application of Direct Infusion Nanoelectrospray HRMS Method for Large-Scale Urinary Metabolic Phenotyping in Molecular Epidemiology

2017 ◽  
Vol 16 (4) ◽  
pp. 1646-1658 ◽  
Author(s):  
Elena Chekmeneva ◽  
Gonçalo dos Santos Correia ◽  
Queenie Chan ◽  
Anisha Wijeyesekera ◽  
Adrienne Tin ◽  
...  
Keyword(s):  
Molecular Epidemiology ◽  
Large Scale ◽  
Direct Infusion ◽  
Metabolic Phenotyping

scholarly journals Development and Application of Ultra-Performance Liquid Chromatography-TOF MS for Precision Large Scale Urinary Metabolic Phenotyping

2016 ◽  
Vol 88 (18) ◽  
pp. 9004-9013 ◽  
Author(s):  
Matthew R. Lewis ◽  
Jake T. M. Pearce ◽  
Konstantina Spagou ◽  
Martin Green ◽  
Anthony C. Dona ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Large Scale ◽  
Ultra Performance Liquid Chromatography ◽  
Metabolic Phenotyping ◽  
Tof Ms

Some comments about observations and image processing of comet 29P/Schwassmann-Wachmann 1

1999 ◽  
Vol 173 ◽  
pp. 243-248
Author(s):  
D. Kubáček ◽  
A. Galád ◽  
A. Pravda
Keyword(s):  
Image Processing ◽  
Large Scale ◽  
Harvard College ◽  
Oak Ridge ◽  
Large Scale Structures ◽  
Short Period Comet ◽  
Short Period ◽  
Scale Structures ◽  
Harvard College Observatory ◽  
Period Comet

AbstractUnusual short-period comet 29P/Schwassmann-Wachmann 1 inspired many observers to explain its unpredictable outbursts. In this paper large scale structures and features from the inner part of the coma in time periods around outbursts are studied. CCD images were taken at Whipple Observatory, Mt. Hopkins, in 1989 and at Astronomical Observatory, Modra, from 1995 to 1998. Photographic plates of the comet were taken at Harvard College Observatory, Oak Ridge, from 1974 to 1982. The latter were digitized at first to apply the same techniques of image processing for optimizing the visibility of features in the coma during outbursts. Outbursts and coma structures show various shapes.

Evolution of Large-Scale Coronal Structures

1994 ◽  
Vol 144 ◽  
pp. 29-33
Author(s):  
P. Ambrož
Keyword(s):  
Magnetic Field ◽  
Field Line ◽  
Large Scale ◽  
Coronal Magnetic Field ◽  
Source Surface ◽  
Solar Cycles ◽  
Characteristic Relationship ◽  
The Magnetic Field ◽  
Coronal Structures

AbstractThe large-scale coronal structures observed during the sporadically visible solar eclipses were compared with the numerically extrapolated field-line structures of coronal magnetic field. A characteristic relationship between the observed structures of coronal plasma and the magnetic field line configurations was determined. The long-term evolution of large scale coronal structures inferred from photospheric magnetic observations in the course of 11- and 22-year solar cycles is described.Some known parameters, such as the source surface radius, or coronal rotation rate are discussed and actually interpreted. A relation between the large-scale photospheric magnetic field evolution and the coronal structure rearrangement is demonstrated.

Sign in / Sign up

Export Citation Format

Share Document