Biomarkers of statin-induced musculoskeletal pain: Vitamin D and beyond

Purpose: To investigate the effect of weekly single high dose vitamin D supplementation on serum 25-hydroxyvitamin D [25(OH)D], and non-specific musculoskeletal pain in female nurses. Methods: In this prospective study in Kashan/Iran, from April 1, 2014, through September 30, 2014, the 150 nurses with vitamin D deficiency received the weekly pearls of 50,000 units of vitamin D3 for 10 weeks. The serum level of 25(OH)D was measured before and after supplement therapy. The subjects were also asked to complete the Extended Nordic Musculoskeletal Questionnaire. All analyses were conducted with SPSS version 16. Results: After 10 weeks of intervention there was [Formula: see text][Formula: see text]ng/mL increase in 25(OH)D. The 82 nurses (54.7%) had 25(OH)D in normal range, while the 68 nurses (45.3%) were still vitamin D deficient. Weight could explain 15.4% increase in 25(OH)D. Before intervention 135 (90%), of nurses reported musculoskeletal pain in at least one region, after intervention this number decreased to 72.7%. There was a statistically significant improvement in musculoskeletal pain in neck, shoulders, upper back, lower back, hips/tights, knees, and ankles/feet after intervention. Conclusions: The weekly single high dose of vitamin D for 10 weeks could resolve vitamin D deficiency in about half of the patients. Patients with non-specific musculoskeletal pain might benefit from vitamin D supplementation.

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Chronic musculoskeletal pain in females as a manifesatation of Vitamin D deficiency in Saudi Arabia

Ibnosina Journal of Medicine and Biomedical Sciences ◽

10.4103/1947-489x.211012 ◽

2010 ◽

Vol 2 (6) ◽

pp. 293

Author(s):

AishaM Siddiqui

Keyword(s):

Vitamin D ◽

Saudi Arabia ◽

Vitamin D Deficiency ◽

Musculoskeletal Pain ◽

Chronic Musculoskeletal Pain

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Effects of Nutritional Interventions in the Control of Musculoskeletal Pain: An Integrative Review

Nutrients ◽

10.3390/nu12103075 ◽

2020 ◽

Vol 12 (10) ◽

pp. 3075

Author(s):

Carolina Rodrigues Mendonça ◽

Matias Noll ◽

Maria Clara Rezende Castro ◽

Erika Aparecida Silveira

Keyword(s):

Fatty Acids ◽

Vitamin D ◽

Musculoskeletal Pain ◽

Inflammatory Markers ◽

Integrative Review ◽

Food Groups ◽

Omega 3 ◽

Fruit Peel ◽

Nutritional Interventions ◽

Positive Effects

Food consumption has significant positive effects on an individual’s health status, including the reduction of symptoms associated with musculoskeletal pain. However, specific food groups indicated for the treatment of pain are not yet determined. Hence, this review aimed to analyze the effects of nutritional interventions with specific diets, oils and/or fatty acids, and foodstuffs in natura in the reduction of musculoskeletal pain. An integrative review was conducted in the following databases: Embase, PubMed, LILACS, and Google Scholar. Clinical trials written in English, Spanish, and Portuguese and published between 2000 and March 2020 were included in this review. Seventeen studies were included. Among these, a reduction of musculoskeletal pain with different types of nutritional interventions, such as vegan and Mediterranean diets and the consumption of blueberry, strawberry, passion fruit peel extract, argan oil, fish oil (omega-3), olive oil, and undenatured type II collagen and vitamin D gel capsules, was observed in 14 studies. Eight studies evaluated the profiles of several inflammatory markers, and of these, decreased interleukin (IL)-6, IL-1β, and tumor necrosis factor-α levels were observed in two studies. This review suggests that different nutritional interventions with specific diets, oils and/or fatty acids, and foodstuffs in natura reduce musculoskeletal pain, specifically in adults with osteoarthritis. Besides pain improvement, nutritional interventions, including the consumption of strawberry and vitamin D gel capsules, decrease the levels of several inflammatory markers.

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