Effects of Nutritional Interventions in the Control of Musculoskeletal Pain: An Integrative Review

Food consumption has significant positive effects on an individual’s health status, including the reduction of symptoms associated with musculoskeletal pain. However, specific food groups indicated for the treatment of pain are not yet determined. Hence, this review aimed to analyze the effects of nutritional interventions with specific diets, oils and/or fatty acids, and foodstuffs in natura in the reduction of musculoskeletal pain. An integrative review was conducted in the following databases: Embase, PubMed, LILACS, and Google Scholar. Clinical trials written in English, Spanish, and Portuguese and published between 2000 and March 2020 were included in this review. Seventeen studies were included. Among these, a reduction of musculoskeletal pain with different types of nutritional interventions, such as vegan and Mediterranean diets and the consumption of blueberry, strawberry, passion fruit peel extract, argan oil, fish oil (omega-3), olive oil, and undenatured type II collagen and vitamin D gel capsules, was observed in 14 studies. Eight studies evaluated the profiles of several inflammatory markers, and of these, decreased interleukin (IL)-6, IL-1β, and tumor necrosis factor-α levels were observed in two studies. This review suggests that different nutritional interventions with specific diets, oils and/or fatty acids, and foodstuffs in natura reduce musculoskeletal pain, specifically in adults with osteoarthritis. Besides pain improvement, nutritional interventions, including the consumption of strawberry and vitamin D gel capsules, decrease the levels of several inflammatory markers.

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Seafood Consumption and Its Contribution to Nutrients Intake among Canadians in 2004 and 2015

Nutrients ◽

10.3390/nu13010077 ◽

2020 ◽

Vol 13 (1) ◽

pp. 77

Author(s):

Xue Feng Hu ◽

Hing Man Chan

Keyword(s):

Fatty Acids ◽

Vitamin D ◽

Consumption Rate ◽

Saturated Fatty Acids ◽

Age Groups ◽

Canadian Community Health Survey ◽

Portion Size ◽

Food Sources ◽

Seafood Consumption ◽

Omega 3

Fish and seafood are excellent sources of nutrients such as omega-3 fatty acids, Vitamin D, and selenium. The aims of this study were to examine the pattern of seafood consumption among Canadians and determine their contribution to intakes of energy and nutrients. Day-1 24-h dietary recalls data collected from a national survey, the Canadian Community Health Survey—Nutrition in 2004 and 2015, were used to estimate food and nutrient intakes among Canadians. Seafood was classified according to the Bureau of Nutritional Sciences food list. Descriptive statistics were used to calculate the consumption rate and the average consumption amount of seafood by different age groups and sociodemographic characteristics. Population ratios were used to assess the contribution of seafood to the total intake of energy and nutrients. The overall consumption rate of seafood was around 17%, and the rate was similar between males and females, and slightly higher in 2015 (17.71%) compared to 2004 (16.38%). The average portion size is approximately 100 g, which translates into a ≈36 kg annual intake among the consumers and ≈6.2 kg per capita consumption. Adults (especially 30 years and above), Asians, individuals who were married, and with post-secondary education were more likely to consume seafood. Salmon, tuna, shrimp, cod, and crab were the most frequently consumed seafood in Canada, the consumption rate of which all increased from 2004 to 2015. Seafood provided up to 75% of n-3 PUFAs, 18% of Vitamin D, 19% Vitamin B12, 6% of niacin, and 4% of Vitamin B6 from all food sources. Seafood consumers had a healthier diet, as seafood consumption was related to a higher intake of key nutrients and a lower intake of total sugar and saturated fatty acids. Therefore, fish consumption should be promoted among Canadians.

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Fish consumption, contaminants and sudden unexpected death in epilepsy: many more benefits than risks

Brazilian Journal of Biology ◽

10.1590/s1519-69842010000300026 ◽

2010 ◽

Vol 70 (3) ◽

pp. 665-670 ◽

Cited By ~ 7

Author(s):

FA. Scorza ◽

RM. Cysneiros ◽

RM. Arida ◽

VC. Terra ◽

HR. Machado ◽

...

Keyword(s):

Fatty Acids ◽

Fish Consumption ◽

Sudden Unexpected Death ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Unexpected Death ◽

Positive Effects ◽

Increased Risk ◽

Fish And Shellfish

People with epilepsy have an increased risk of dying prematurely and the most common epilepsy-related category of death is sudden unexpected death in epilepsy (SUDEP). SUDEP is mainly a problem for patients with chronic uncontrolled epilepsy. The ultimate goal of research in SUDEP is to develop new methods to prevent it and actions other than medical and surgical therapies that could be very useful. Nutritional aspects, i.e., omega-3 fatty acids deficiency, could have an interesting role in this scenario. Some animal and clinical studies have suggested that omega-3 fatty acids could be useful in the prevention and treatment of epilepsy and hence SUDEP. It has been ascertained that the only foods that provide large amounts of omega-3 are seafood (fish and shellfish); however, some fish are contaminated with methylmercury, which may counteract the positive effects of omega-3 fatty acids. Our update review summarises the knowledge of the role of fish consumption on epilepsy research.

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Metabolism of fatty acids, secondary complications and effects of physical exercise: integrative review

Revista Brasileira de Fisiologia do Exercício ◽

10.33233/rbfe.v19i2.4085 ◽

2020 ◽

Vol 19 (2) ◽

pp. 154

Author(s):

Djeyne Silveira Wagmacker ◽

Alice Miranda De Oliveira ◽

Edna Conceição De Oliveira ◽

Alan Carlos Nery Dos Santos ◽

Luiz Erlon Araújo Rodrigues ◽

...

Keyword(s):

Fatty Acids ◽

Fatty Acid ◽

Physical Exercise ◽

Fatty Acid Metabolism ◽

Acid Metabolism ◽

Spatial Configuration ◽

Integrative Review ◽

Metabolic Disturbances ◽

Secondary Complications ◽

Positive Effects

Introduction: Diet is a complex set of exposures that frequently interact, and whose cumulative effects influence the results of health. This includes effects on systemic inflammation markers in metabolic disturbances and cardiovascular diseases. Various studies have been presented relating the effect of physical exercise on lipids, however, the results are still controversial. Objective: To describe fatty acid metabolism and the effect of physical exercise on secondary complications. Methods: An integrative review was conducted on topics in the Medline, Pubmed, Web of Science and Scopus databases, published up to the year 2017. Results: Fatty acids, depending on their biochemical characteristics and spatial configuration, have differentiated effect on cardiovascular health, however, studies still present contradictory results about the therapeutic use of certain fatty acids. Physical exercise appears to benefit fatty acid metabolism and attenuate the complications secondary to the intake of certain fatty acids, and potentializes the positive effects of distinct fatty acids. Conclusion: However, variants of physical exercise, such as intensity, duration, time of observation of effects of the results, limit the authors to concluding, with a certain degree of certainty, about the effect of physical exercise on fatty acids and secondary complications, since the studies in the literature continue to be contradictory.Keywords: fatty acids, exercise, inflammation, oxidative stress.

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High omega-3 fatty acids and low omega-6/omega-3 ratio but not polyphenols in diet decrease inflammatory markers in men with chronic coronary syndrome treated with percutaneous coronary intervention

Kardiologia Polska ◽

10.33963/kp.15078 ◽

2019 ◽

Cited By ~ 1

Author(s):

Agnieszka Sut ◽

Krzysztof Chiżyński ◽

Marcin Różalski, ◽

Jacek Golański Golański

Keyword(s):

Fatty Acids ◽

Percutaneous Coronary Intervention ◽

Inflammatory Markers ◽

Coronary Intervention ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Coronary Syndrome ◽

Percutaneous Coronary ◽

Omega 6

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Effect of Dietary Enrichment with Omega 3 and 6 Fatty Acids on Blood Metabolites, Hormone Concentration and Ovarian Function in Sahiwal Heifers

Indian Journal of Animal Research ◽

10.18805/ijar.b-3939 ◽

2021 ◽

Author(s):

Sushil Kumar ◽

Sajjan Sihag ◽

Zile Singh Sihag ◽

Chandershekhar Santosh Patil ◽

Surender Singh Dhaka ◽

...

Keyword(s):

Fatty Acids ◽

Fatty Acid ◽

Unsaturated Fatty Acids ◽

Ovarian Function ◽

Linseed Oil ◽

Hdl Cholesterol ◽

Blood Metabolites ◽

Omega 3 ◽

Positive Effects ◽

Concentrate Mixture

Background: Supplementation of fat, especially those having unsaturated fatty acids has been proposed to carry positive effects on the reproductive organ, beside providing dietary energy to the animals. This experiment was designed to examine the effects of dietary ω-3 or ω-6 fatty acid (FA) rich oil supplementation on blood FA, metabolite and hormone concentrations; ovarian follicular growth and corpus luteum (CL) size in Sahiwal breed heifers.Methods: Eighteen heifers of 18.33±1.14 months of age and 194±4.16 kg of mean body weight were randomly assigned to 3 diets and individually fed as per ICAR (2013) diets. The diets include chopped wheat straw, green fodder and concentrate mixture containing either (i) no added PUFA rich oil but palm oil @ 3.5% (PO; n=6); (ii) 3.5% added soybean oil as ω-6 FA source (SO; n=6); or (iii) 3.5% added linseed oil as ω-3 FA source (LO; n=6).Result: SO increased (P less than 0.05) the plasma concentration of ω-6 FA while LO increased (P less than 0.05) the plasma ω-3 FA. Plasma glucose, triglyceride and non-esterified fatty acid (NEFA) concentrations was not affected due to different diets. Plasma total cholesterol and HDL-cholesterol were significantly higher (P less than 0.05) in SO and LO in comparison to PO. However, LDL-cholesterol was at par among all the treatments. Growth Hormone (GH) was not influenced due to different types of oil in heifers’ concentrate mixture. Insulin concentration increased (P less than 0.05) in LO compared to others. IGF-1 was statistically higher (P less than 0.05) in SO and LO as compared to CON, which among themselves also varied significantly. Plasma progesterone concentration at day 12 post estrous was higher (P less than 0.05) in LO. PUFA rich oil supplementation in the concentrate mixture of heifers (SO and LO) increased (P less than 0.05) the size of the ovulatory follicles as well as size of CL. It was inferred that feeding PUFA rich oil to pre-pubertal Sahiwal heifer’s results in advantageous changes in the blood metabolites, plasma hormones and ovarian functions.

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Vitamin D and Omega-3 Polyunsaturated Fatty Acids in Type 1 Diabetes modulation

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530322666220103114450 ◽

2022 ◽

Vol 22 ◽

Author(s):

Thais Sibioni Berti Bastos ◽

Tárcio Teodoro Braga ◽

Mariana Rodrigues Davanso

Keyword(s):

Fatty Acids ◽

Vitamin D ◽

Type 1 Diabetes ◽

Polyunsaturated Fatty Acids ◽

Immune Cell ◽

Omega 3 ◽

Β Cells ◽

Potential Benefits ◽

Chronic Autoimmune Disease

Background: Type 1 diabetes (T1D) is a chronic autoimmune disease that affects people globally. Usually developed during childhood, T1D is characterized by the destruction of pancreatic β-cells due to immune cell attack and the establishment of an inflammatory process. Objective: The study aimed to investigate the effects of vitamin D through its nuclear receptor and the ω-3 polyunsaturated fatty acids (PUFAs) through their lipid derivatives in T1D modulation. Both components exert anti-inflammatory activity and act directly on cells of the immune system, attenuating the destruction of insulin-producing cells. Furthermore, they lead to a better glycemic level, reducing the need for insulin and a normal immune state, such as C-peptide maintenance. Method: Presently, our review highlights the significant studies that evaluated the supplementation of vitamin D and ω-3 PUFAs in humans and animal models in the modulation of T1D. Conclusion: The data collected suggests that supplementation can provide potential benefits, mainly when done early in the diagnosis, since it reduces the need for insulin and the risk of complications generated by the disease.

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Nutraceutical Approach to Non-Alcoholic Fatty Liver Disease (NAFLD): The Available Clinical Evidence

Nutrients ◽

10.3390/nu10091153 ◽

2018 ◽

Vol 10 (9) ◽

pp. 1153 ◽

Cited By ~ 29

Author(s):

Arrigo Cicero ◽

Alessandro Colletti ◽

Stefano Bellentani

Keyword(s):

Fatty Acids ◽

Vitamin D ◽

Liver Disease ◽

Vitamin E ◽

Fatty Liver ◽

Coenzyme Q10 ◽

Fatty Liver Disease ◽

Omega 3 ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) is a clinical condition characterized by lipid infiltration of the liver, highly prevalent in the general population affecting 25% of adults, with a doubled prevalence in diabetic and obese patients. Almost 1/3 of NAFLD evolves in Non-Alcoholic SteatoHepatitis (NASH), and this can lead to fibrosis and cirrhosis of the liver. However, the main causes of mortality of patients with NAFLD are cardiovascular diseases. At present, there are no specific drugs approved on the market for the treatment of NAFLD, and the treatment is essentially based on optimization of lifestyle. However, some nutraceuticals could contribute to the improvement of lipid infiltration of the liver and of the related anthropometric, haemodynamic, and/or biochemical parameters. The aim of this paper is to review the available clinical data on the effect of nutraceuticals on NAFLD and NAFLD-related parameters. Relatively few nutraceutical molecules have been adequately studied for their effects on NAFLD. Among these, we have analysed in detail the effects of silymarin, vitamin E, vitamin D, polyunsaturated fatty acids of the omega-3 series, astaxanthin, coenzyme Q10, berberine, curcumin, resveratrol, extracts of Salvia milthiorriza, and probiotics. In conclusion, Silymarin, vitamin E and vitamin D, polyunsaturated fatty acids of the omega-3 series, coenzyme Q10, berberine and curcumin, if well dosed and administered for medium–long periods, and associated to lifestyle changes, could exert positive effects on NAFLD and NAFLD-related parameters.

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