Bone remodeling markers and bone cancer

Mathematical modeling of biological processes has bridged the fields of experimental as well as theoretical research and has carried forward remarkable innovation. Sclerostin is a fundamental communication element for bone remodeling and its activity regulates the reabsorption and deposition of new bone tissue. During this research, we have presented several studies, which illustrate the function of sclerostin in communication with the Wnt signaling pathways. This article features the sclerostin-based pathological patterns related to diseases such as bone cancer. To have a good remodeling process, the osteocytes must recruit the pre-osteoblast cells from the mesenchymal stem cells with the help of the signal mechanism given by the Wnt pathway. The Wnt signal pathway is a complex transduction of a pool of well-conserved genes whose expression regulates various activities like gene translation, cell adhesion, cell differentiation, mitogenic stimulation and polarity cell. The complexity of the interaction of the Wnt pathway is due to the ligands of Wnt itself, to the proteins R-spondin and norrin. The receptors on the surface of the cell, then, activate a process of transduction of the intracellular signal that initiates gene transduction. The hypothesis of a sort of “steady state” has therefore proved indispensable to establish a sort of common base on which the two phases. This paper seeks to give a qualitative view of the action of sclerostin through a simple mathematical model. We use a logic related to stimulation and inhibition signals of new tissue production and illustrate the role of sclerostin in the mechanical and biochemical interaction during the bone remodeling process.

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Body composition, adipokines, bone mineral density and bone remodeling markers in relation to IGF-1 levels in adults with Prader-Willi syndrome

International Journal of Pediatric Endocrinology ◽

10.1186/s13633-018-0055-4 ◽

2018 ◽

Vol 2018 (1) ◽

Cited By ~ 3

Author(s):

I. Caroline van Nieuwpoort ◽

Jos W. R. Twisk ◽

Leopold M. G. Curfs ◽

Paul Lips ◽

Madeleine L. Drent

Keyword(s):

Bone Mineral Density ◽

Body Composition ◽

Bone Remodeling ◽

Bone Mineral ◽

Prader Willi Syndrome ◽

Mineral Density ◽

Bone Remodeling Markers

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Glucagon-like peptide 1 and Glucagon-like peptide 2 in relation to osteoporosis in non-diabetic postmenopausal women

Scientific Reports ◽

10.1038/s41598-019-50117-z ◽

2019 ◽

Vol 9 (1) ◽

Author(s):

María Cristina Montes Castillo ◽

María José Martínez Ramírez ◽

Rubén Soriano Arroyo ◽

Isabel Prieto Gomez ◽

Ana Belén Segarra Robles ◽

...

Keyword(s):

Postmenopausal Women ◽

Bone Remodeling ◽

Plasma Levels ◽

Dipeptidyl Peptidase ◽

Mineral Density ◽

Dipeptidyl Peptidase 4 ◽

Bone Remodeling Markers ◽

Glucagon Like Peptide ◽

Glucagon Like Peptide 1 ◽

Osteoporosis Risk

Abstract Osteoporosis results from an imbalance in bone remodeling, which is known to follow a circadian rhythm determined by a functional relationship between intestine and bone tissue. Specific intestinal peptides have been identified as mediators. Glucagon-like peptide 1 and glucagon-like peptide 2, have been associated with bone health. Our main objective was to determine whether postprandial plasma levels of glucagon-like peptide 1, glucagon-like peptide 2 and dipeptidyl-peptidase 4 activity, are associated with osteoporosis in non-diabetic postmenopausal women. We studied non-diabetic postmenopausal women with osteoporosis diagnosed by dual-energy X-ray absorptiometry (cases, n = 43) and age-matched (±1 yr) controls without osteoporosis or a history of osteoporotic fracture (n = 43). We measured postprandial plasma levels of glucagon-like peptide 1, glucagon-like peptide 2, and dipeptidyl-peptidase 4 activity, bone mineral density, and baseline levels of bone remodeling markers and analyzed the food intake using a food-frequency questionnaire. Postprandial glucagon-like peptide 1 values were lower (p < 0.001) in cases, μ (SEM) = 116.25 (2.68), than in controls, μ (SEM) = 126.79 (2.68). Glucagon-like peptide 1 was associated with reduced osteoporosis risk in the crude logistic regression analysis [OR (95% CI) = 0.724 (0.53–0.97), p = 0.031] and adjusted analysis [OR = 0.603 (0.38–0.94), p = 0.027]. We found no association of glucagon-like peptide 2, or dipeptidyl-peptidase 4 activity with osteoporosis. Postprandial glucagon-like peptide 1 levels are related to osteoporosis and osteoporosis risk in non-diabetic postmenopausal women. Further studies are required to verify these findings.

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Prediction of Bone Mass Density Variation by Bone Remodeling Markers in Postmenopausal Women with Vitamin D Insufficiency Treated with Calcium and Vitamin D Supplementation

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2002-021968 ◽

2003 ◽

Vol 88 (11) ◽

pp. 5175-5179 ◽

Cited By ~ 49

Author(s):

Franck Grados ◽

Michel Brazier ◽

Saïd Kamel ◽

Marc Mathieu ◽

Nathalie Hurtebize ◽

...

Keyword(s):

Vitamin D ◽

Bone Remodeling ◽

Elderly Women ◽

Vitamin D Insufficiency ◽

Vitamin D Supplementation ◽

Hydroxyvitamin D ◽

Bone Remodeling Markers ◽

25 Hydroxyvitamin D ◽

Total Body

Abstract The aim of this study was to determine whether early changes in bone markers could predict long-term response in bone mineral density (BMD) after calcium (500 mg) and vitamin D (400 IU) supplementation twice daily in ambulatory elderly women with vitamin D insufficiency (25-hydroxyvitamin D, <12 ng/ml). One hundred and ninety-two women (mean age, 75 ± 7 yr) were randomized to receive either the supplementation (n = 95) or a placebo (n = 97) in a double-blind, controlled clinical trial for 1 yr. In comparison with the placebo group, supplementation significantly increased BMD, normalized 25-hydroxyvitamin D and significantly decreased intact PTH and bone remodeling markers. The initial values of telopeptide cross-links were correlated with improvement in total body BMD [urinary N-telopeptides (NTX), r = 0.38; C-telopeptides (CTX), r = 0.32; serum CTX, r = 0.28], and the 3-month changes in the same markers were correlated with improvement in total body (urinary N-telopeptides, r = −0.29; serum CTX, r = −0.26) and vertebral BMD (CTX, r = −0.26; all P < 0.05). We concluded that short-term changes in bone resorption markers can predict long-term variations in BMD in elderly women with vitamin D insufficiency receiving calcium and vitamin D supplementation.

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