scholarly journals Quality control of herbal medicinal products and the South African perspective

2022 ◽  
pp. xv-xx
Author(s):  
Alvaro Viljoen ◽  
Weiyang Chen ◽  
Nduvho Mulaudzi ◽  
Guy Kamatou ◽  
Maxleene Sandasi
Keyword(s):  
Quality Control ◽  
South African ◽  
Medicinal Products ◽  
The South ◽  
Herbal Medicinal Products ◽  
African Perspective ◽  
Herbal Medicinal

scholarly journals Review: DNA Barcoding and Chromatography Fingerprints for the Authentication of Botanicals in Herbal Medicinal Products

2017 ◽  
Vol 2017 ◽  
pp. 1-28 ◽  
Author(s):  
Bashir Mohammed Abubakar ◽  
Faezah Mohd Salleh ◽  
Mohd Shahir Shamsir Omar ◽  
Alina Wagiran
Keyword(s):  
Quality Control ◽  
Dna Barcoding ◽  
Rapid Identification ◽  
Efficacy And Safety ◽  
Medicinal Products ◽  
Chromatographic Fingerprint ◽  
Closely Related Species ◽  
Herbal Medicinal Products ◽  
Herbal Medicinal ◽  
Process Product

In the last two decades, there has been a tremendous increase in the global use of herbal medicinal products (HMPs) due to their claimed health benefits. This has led to increase in their demand and consequently, also, resulted in massive adulteration. This is due to the fact that most of the traditional methods cannot identify closely related species in a process product form. Therefore the urgent need for simple and rapid identification methods resulted in the discovery of a novel technique. DNA barcoding is a process that uses short DNA sequence from the standard genome for species identification. This technique is reliable and is not affected by external factors such as climates, age, or plant part. The difficulties in isolation of DNA of high quality in addition to other factors are among the challenges encountered using the DNA barcoding in the authentication of HMP. These limitations indicated that using DNA barcoding alone may ineffectively authenticate the HMP. Therefore, the combination of DNA barcoding with chromatographic fingerprint, a popular and generally accepted technique for the assessment and quality control of HMP, will offer an efficient solution to effectively evaluate the authenticity and quality consistency of HMP. Detailed and quality information about the main composition of the HMPs will help to ascertain their efficacy and safety as these are very important for quality control.

Quality Control of Herbal Medicinal Products

2020 ◽  
pp. 143-157
Author(s):  
Javed Ahamad ◽  
Esra T. Anwer ◽  
Muath Sh. Mohammed Ameen ◽  
Jamia Firdous ◽  
Nehal Mohsin
Keyword(s):  
Quality Control ◽  
Medicinal Products ◽  
Herbal Medicinal Products ◽  
Herbal Medicinal

scholarly journals Validation of Standardized High-Performance Thin-Layer Chromatographic Methods for Quality Control and Stability Testing of Herbals

2003 ◽  
Vol 86 (5) ◽  
pp. 909-915 ◽  
Author(s):  
Kathrin Koll ◽  
Eike Reich ◽  
Anne Blatter ◽  
Markus Veit
Keyword(s):  
Quality Control ◽  
High Performance ◽  
Active Pharmaceutical Ingredient ◽  
Drug Preparation ◽  
Stability Testing ◽  
Herbal Drug ◽  
Medicinal Products ◽  
Herbal Medicinal Products ◽  
Validation Parameters ◽  
Herbal Medicinal

Abstract In herbal medicinal products the entire herbal drug or an herbal drug preparation is regarded as the active pharmaceutical ingredient, regardless of whether constituents with defined therapeutic activity are known. In quality control and stability testing of herbal medicinal products, fingerprint chromatograms are used as powerful tools to evaluate and compare the composition of compounds in such products. To fulfill the International Conference on Harmonization and Good Manufacturing Practice-based regulatory requirements in pharmaceutical quality control, chromatographic fingerprint analysis needs to be validated. Based on a standardized methodology, this paper provides a comprehensive concept for evaluating validation parameters for planar chromatographic fingerprinting by considering the stationary phase, sample application, developing solvent, chromatogram development, plate labeling, derivatization, documentation, and chromatographic equipment. Validation parameters addressed include stability of the analyte, selectivity, robustness testing, and method reproducibility.

scholarly journals Determination of Arbutin in Herbal Medicinal Products

2021 ◽  
Vol 11 (2) ◽  
pp. 121-129
Author(s):  
N. P. Antonova ◽  
S. S. Prokhvatilova ◽  
E. P. Shefer ◽  
A. M. Kalinin ◽  
I. M. Morgunov ◽  
...  
Keyword(s):  
Quality Control ◽  
High Performance ◽  
Subjective Assessment ◽  
Test Methods ◽  
Medicinal Products ◽  
Herbal Medicinal Products ◽  
Visible Spectrophotometry ◽  
Spectrophotometric Methods ◽  
Titration Endpoint ◽  
Herbal Medicinal

Arbutin is the main active ingredient in many herbal medicinal products that have diuretic, antimicrobial, bactericidal, and antioxidant effects. Many of these products are mixtures of different herbal substances. Therefore, the approaches to quality control of HMPs can vary significantly. The aim of the study was to compare arbutin assay procedures used in quality control of arbutin-containing products. Materials and methods. Samples of the following HMPs were used in the study: monocomponent Bearberry Leaf and multicomponent Brusniver® (herbal mixture, powder). The test methods used were titrimetry, ultraviolet-visible spectrophotometry, and high-performance liquid chromatography (HPLC). Results. The authors compared five arbutin assay procedures described in the monographs and product files for arbutin-containing HMPs. Conclusions. It has been established that the analysed procedures cannot be used interchangeably as equivalent test methods; the limits for arbutin have to be established for each specific procedure. Iodometric titration is the most labour- and time-consuming method, and the determined titration endpoint is a subjective assessment. Spectrophotometric methods do not require the use of an arbutin reference standard, but they can give overestimated results as compared to the HPLC and titrimetry methods. HPLC methods are more selective, but they require the use of reference standards. The recommended test methods for HMP quality control are HPLC and visible spectrophotometry; the titrimetric method is recommended for replacement.

Current Application of Chemometrics Analysis in Authentication of Natural Products: A Review

2021 ◽  
Vol 24 ◽  
Author(s):  
Abdelkrim Rebiai ◽  
Hadia Hemmami ◽  
Soumeia Zeghoud ◽  
Bachir Ben Seghir ◽  
Imane Kouadri ◽  
...  
Keyword(s):  
Quality Control ◽  
Herbal Medicines ◽  
Medicinal Products ◽  
Bioactive Components ◽  
Active Components ◽  
Current Application ◽  
Closely Related Species ◽  
Herbal Medicinal Products ◽  
Analysis Techniques ◽  
Herbal Medicinal

Background: The efficiency of herbal medicinal products depends on the quantity of active ingredients in them, which can differ considerably in contents. Hence, a very critical concern is the quality control of herbal medicines. Objective: To provide a succinct review of recent chemometrics applications in solving the uncertainty of the authentication of herbal medicine over the last two decades. Methodology: Studies involving chemometrics applications in conjunction with various analytical methods have been categorized according to the type of research used in the quality evaluation of different samples, including chromatographic (HPLC, GC-MS) and spectroscopic analysis (UV-Vis, FTIR, NMR, and MS). Results: This review consists of over 90 studies illustrating the relevance of chemometrics methods in the discrimination based on the key bioactive components and phytochemical diversity of several herbs from closely related species. Besides, the distinction between varieties and hybrids was accomplished through quantitative analysis techniques, in addition to the prediction of the active components. Conclusion: Methods of chemometrics have provided an important and potent tool for the quality control and authentication of various herbs.

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