Foreword from the Eighth Edition

This essay argues that the work of a lesser-known mid-eighteenth-century satirist Charles Churchill (1731–1764) provides a rich literary source for queer historical considerations of the conflation of xenophobia with effeminophobia in colonial imaginings of Ireland. This article analyzes Churchill's verse-satire The Rosciad (1761) through a queer lens in order to reengage the complex history of queer figurations of Ireland and the Irish within the British popular imagination. In the eighth edition of The Rosciad – a popular and controversial survey of London's contemporary players – Churchill portrays the Irish actor Thady Fitzpatrick as an effeminate fribble, before championing the manly acting abilities of the English actor David Garrick. The phobic attack on Fitzpatrick in The Rosciad is a direct response to Fitzpatrick's involvement in the ‘Fitzgiggo’ riots of January 1763 at the Drury Lane and Covent-Garden theatres. While Churchill's lampooning of the actor recalls Garrick's earlier satirizing of Fitzpatrick as a fribble in The Fribbleriad (1741) and Miss in her Teens (1747), The Rosciad is unique in its explicit conflation of androgyny with ethnicity through Irish classification. The portraiture of Fitzpatrick functions, alongside interrelated axes of ethnicity, class and gender, to prohibit access to a ‘normative’ middle-class English identity, figured through the ‘manly’ theatrical sensibility of the poem's hero, Garrick. Moreover, in celebrating a ‘Truly British Age’, the poem privileges English female players, in essentialist and curiously de-eroticized terms, as ‘natural’ though flawed performers. By analyzing Churchill's phobic juxtaposition of Garrick and the female players against the Irish fribble, this article evinces how mid-century discourses of effeminacy were also instrumental in enforcing racial taxonomies.

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Faculty Opinions recommendation of The IASLC mesothelioma staging project: proposals for revisions of the N descriptors in the forthcoming eighth edition of the TNM classification for pleural mesothelioma.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726791524.793551904 ◽

2018 ◽

Author(s):

Paul Van Schil

Keyword(s):

Tnm Classification ◽

Pleural Mesothelioma ◽

Eighth Edition

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Prognostic Heterogeneity of the Eighth Edition of AJCC Stage IVB Gallbladder Cancer: T1-3N2M0 Should Be Categorized as Stage IIIC

SSRN Electronic Journal ◽

10.2139/ssrn.3223094 ◽

2018 ◽

Author(s):

Zhengshi Wang ◽

Haiyang Zhou ◽

Anqi Duan ◽

Kaizhou Jin ◽

Qiuyi Huang ◽

...

Keyword(s):

Gallbladder Cancer ◽

Stage Iiic ◽

Ajcc Stage ◽

Stage Ivb ◽

Eighth Edition

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Validation of the Proposed cN2 Subclassification in the Eighth Edition of the IASLC Staging System: A Prospective Phase II Multicenter Study

JTO Clinical and Research Reports ◽

10.1016/j.jtocrr.2020.100019 ◽

2020 ◽

Vol 1 (2) ◽

pp. 100019

Author(s):

Jiro Abe ◽

Yuji Matsumura ◽

Satoshi Shiono ◽

Masaya Aoki ◽

Masami Sato ◽

...

Keyword(s):

Phase Ii ◽

Multicenter Study ◽

Staging System ◽

System A ◽

Prospective Phase ◽

Eighth Edition

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Conjunctival melanoma treatment outcomes in 288 patients: a multicentre international data-sharing study

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2020-316293 ◽

2020 ◽

pp. bjophthalmol-2020-316293

Author(s):

Puneet Jain ◽

Paul T Finger ◽

Maria Fili ◽

Bertil Damato ◽

Sarah E Coupland ◽

...

Keyword(s):

Local Recurrence ◽

Local Excision ◽

External Beam Radiotherapy ◽

Staging System ◽

Primary Treatment ◽

Excision Biopsy ◽

Conjunctival Melanoma ◽

Recurrence Rates ◽

Increased Risk ◽

Eighth Edition

BackgroundTo relate conjunctival melanoma characteristics to local control.MethodsRetrospective, registry-based interventional study with data gathered from 10 ophthalmic oncology centres from 9 countries on 4 continents. Conjunctival melanoma patients diagnosed between January 2001 and December 2013 were enrolled in the study. Primary treatments included local excision, excision with cryotherapy and exenteration. Adjuvant treatments included topical chemotherapy, brachytherapy, proton and external beam radiotherapy (EBRT). Cumulative 5-year and 10-year Kaplan-Meier local recurrence rates were related to clinical and pathological T-categories of the eighth edition of the American Joint Committee on Cancer (AJCC) staging system.Results288 patients had a mean initial age of 59.7±16.8 years. Clinical T-categories (cT) were cT1 (n=218,75.7%), cT2 (n=34, 11.8%), cT3 (n=15, 5.2%), cTx (n=21,7.3%) with no cT4. Primary treatment included local excision (n=161/288, 55.9%) followed by excision biopsy with cryotherapy (n=108/288, 37.5%) and exenteration (n=5/288, 1.7%). Adjuvant therapies included topical mitomycin (n=107/288, 37.1%), plaque-brachytherapy (n=55/288, 19.1%), proton-beam (n=36/288, 13.5%), topical interferon (n=20/288, 6.9%) and EBRT (n=15/288, 5.2%). Secondary exenteration was performed (n=11/283, 3.9%). Local recurrence was noted in 19.1% (median=3.6 years). Cumulative local recurrence was 5.4% (3.2–8.9%), 19.3% (14.4–25.5%) and 36.9% (26.5–49.9%) at 1, 5 and 10 years, respectively. cT3 and cT2 tumors were twice as likely to recur than cT1 tumours, but only cT3 had statistically significantly greater risk of local recurrence than T1 (p=0.013). Factors such as tumour ulceration, plica or caruncle involvement and tumour thickness were not significantly associated with an increased risk of local recurrence.ConclusionThis multicentre international study showed that eighth edition of AJCC tumour staging was related to the risk of local recurrence of conjunctival melanoma after treatment. The 10-year cumulative local recurrence remains high despite current management.

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Prognostic Value of Tumor Size in Resected Stage IIIA-N2 Non-Small-Cell Lung Cancer

Journal of Clinical Medicine ◽

10.3390/jcm9051307 ◽

2020 ◽

Vol 9 (5) ◽

pp. 1307 ◽

Cited By ~ 1

Author(s):

Chih-Yu Chen ◽

Bing-Ru Wu ◽

Chia-Hung Chen ◽

Wen-Chien Cheng ◽

Wei-Chun Chen ◽

...

Keyword(s):

Lung Cancer ◽

Prognostic Factors ◽

Tumor Size ◽

Small Cell ◽

Small Cell Lung ◽

Stage Iiia ◽

Pathologic Stage ◽

The Mean ◽

Eighth Edition ◽

Resected Stage

The eighth edition of the American Joint Committee on Cancer (AJCC) staging system for lung cancer was introduced in 2017 and included major revisions, especially of stage III. For the subgroup stage IIIA-N2 non-small-cell lung cancer (NSCLC), surgical resection remains controversial due to heterogeneous disease entity. The aim of this study was to evaluate the clinicopathologic features and prognostic factors of patients with completely resected stage IIIA-N2 NSCLC. We retrospectively evaluated 77 consecutive patients with pathologic stage IIIA-N2 NSCLC (AJCC eighth edition) who underwent surgical resection with curative intent in China Medical University Hospital between 2006 and 2014. Survival analysis was conducted, using the Kaplan–Meier method. Prognostic factors predicting overall survival (OS) and disease-free survival (DFS) were analyzed, using log-rank tests and multivariate Cox proportional hazards models. Of the 77 patients with pathologic stage IIIA-N2 NSCLC examined, 35 (45.5%) were diagnosed before surgery and 42 (54.5%) were diagnosed unexpectedly during surgery. The mean age of patients was 59 years, and the mean length of follow-up was 38.1 months. The overall one-, three-, and five-year OS rates were 91.9%, 61.3%, and 33.5%, respectively. Multivariate analysis showed that tumor size <3 cm (hazards ratio (HR): 0.373, p = 0.003) and video-assisted thoracoscopic surgery (VATS) approach (HR: 0.383, p = 0.014) were significant predictors for improved OS. For patients with surgically treated, pathologic stage IIIA-N2 NSCLC, tumor size <3 cm and the VATS approach seemed to be associated with better prognosis.

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