Prognostic Heterogeneity of the Eighth Edition of AJCC Stage IVB Gallbladder Cancer: T1-3N2M0 Should Be Categorized as Stage IIIC

e17534 Background: The presence of pleural effusion in the evolution of patients with ovarian cancer is not uncommon. In one series of 123 patients, malignant pleural effusion at the diagnoses was observed in 29%, and 70% during the course of the disease. Methods: This observational, retrospective study included patients with ovarian cancer and pleural effusion between July 2007 and December 2019 in Lleida, province of Catalonia, Spain. Data were collected from electronic medical reports. This study analyzed the clinical features of ovarian cancer patients with pleural effusion and its impact on their survival. Results: Data from 189 patients with ovarian cancer were collected. The median age was 63 years old. Pleural effusion was observed in 81 patients, 55 at the diagnosis and 26 in the disease evolution. Fifty five percent were confirmed as malignant etiology. Most of the patients were diagnosed with an advanced stage (38.3% stage IIIC, 12.3% stage IVA, 40.7% stage IVB), and 74.1% were high-grade serous carcinoma. When the pleural effusion was observed at the diagnosis, the median overall survival was 20.8 vs 69.3 months in the absence of it (p < 0.001). When the pleural effusion was observed at any time of the disease, the median overall survival was 26.7 vs 90.4 months without it (p < 0.001). Conclusions: In this study, patients with ovarian cancer and pleural effusion, at diagnosis or in the course of the disease, experienced reduced survival compared with the absence of it.

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Stage IVB Gallbladder Cancer AJCC v7

10.32388/r4693x ◽

2020 ◽

Author(s):

Keyword(s):

Gallbladder Cancer ◽

Stage Ivb

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A CASE OF STAGE IVb GALLBLADDER CANCER WITH A DISEASE-FREE 15-YEAR SURVIVAL AFTER SURGERY

Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) ◽

10.3919/jjsa.72.2370 ◽

2011 ◽

Vol 72 (9) ◽

pp. 2370-2374

Author(s):

Ichiro IIZUKA ◽

Nobuyosi AOYANAGI

Keyword(s):

Gallbladder Cancer ◽

Stage Ivb ◽

Disease Free

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Stage IVB Gallbladder Cancer AJCC v8

10.32388/yv6xhr ◽

2020 ◽

Author(s):

Keyword(s):

Gallbladder Cancer ◽

Stage Ivb

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Randomized phase II neoadjuvant study of temozolomide (TMZ) alone or with pegylated interferon-alfa 2b (PGI) in patients with resectable AJCC stage IIIC or stage IV (M1a) metastatic melanoma

Journal of Clinical Oncology ◽

10.1200/jco.2008.26.15_suppl.20024 ◽

2008 ◽

Vol 26 (15_suppl) ◽

pp. 20024-20024

Author(s):

W. Hwu ◽

D. Ivan ◽

V. G. Prieto ◽

J. Simon ◽

D. Jones ◽

...

Keyword(s):

Metastatic Melanoma ◽

Phase Ii ◽

Stage Iv ◽

Pegylated Interferon ◽

Interferon Alfa ◽

Stage Iiic ◽

Ajcc Stage ◽

Randomized Phase Ii ◽

Pegylated Interferon Alfa

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Clinical Features and Prognostic Factors of Elderly Patients with Gallbladder Cancer: A Population-Based Study

10.21203/rs.3.rs-612559/v1 ◽

2021 ◽

Author(s):

Jin Shuai ◽

Li Deyu ◽

Lianyuan Tao ◽

Yu Haibo ◽

Tian Guanjing

Keyword(s):

Prognostic Factors ◽

Lymph Node ◽

Elderly Patients ◽

Gallbladder Cancer ◽

Lymph Node Dissection ◽

Clinical Features ◽

Clinical Characteristics ◽

Young Patients ◽

Node Dissection ◽

Ajcc Stage

Abstract Background: Elderly patients with gallbladder cancer (GBC) may be a special group of individuals. The present study aimed to explore the clinical features and prognostic factors of elderly patients with GBC and establish nomogram to predict their overall survival (OS). Methods: Patients diagnosed with GBC from 2010 to 2015 were identified from the Surveillance Epidemiology and End Results database. Clinical characteristics and prognostic factors in elderly GBC patients were examined. Results: Elderly patients and young patients with GBC differed in many aspects, including race, marital status, AJCC stage, T stage, N stage, M stage, surgery, lymph node dissection, radiation, chemotherapy, and OS (P<0.05). Analysis of prognostic factors showed that chemotherapy and surgery with lymph node dissection (radical surgery), as the main treatment for elderly patients, can significantly improve prognosis. Other factors, including being unmarried, higher grade of histological type and AJCC stage, had a negative effect on OS. Nomogram was developed based on the above prognostic factors. The C-indexes of 1-year survival and 3-year survival nomogram were 0.73 and 0.736 and AUCs at 1 and 3 years were 0.789 and 0.780, respectively. Conclusions: Elderly patients with GBC comprise a distinct group of individuals whose clinical characteristics differ from those of young patients, and the nomogram constructed accurately predicted OS in elderly patients with GBC.

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Prognostic significance of the AJCC staging in patients with squamous cell carcinoma of the oropharynx.

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.15_suppl.5529 ◽

2012 ◽

Vol 30 (15_suppl) ◽

pp. 5529-5529

Author(s):

Carlos Rodrigo Acevedo-Gadea ◽

Megan Ann Baumgart ◽

Zuoheng Wang ◽

Hari Anant Deshpande ◽

Marianne Davies ◽

...

Keyword(s):

Squamous Cell ◽

Opposite Effect ◽

Cox Model ◽

Prognostic Significance ◽

Prognostic Impact ◽

Eligibility Criteria ◽

Ajcc Stage ◽

Kaplan Meier ◽

Stage Ivb ◽

Ajcc Staging

5529 Background: There have been significant changes in the epidemiology of head and neck squamous cell carcinomas (HNSCC), with an increase in the incidence of oropharyngeal (OP) cancer and opposite effect in other sites. Since the rise in OP cancer incidence is attributed to human papillomavirus (HPV), which is associated with a different biology and clinical behavior, we evaluated whether the current AJCC system retained its prognostic impact in this patient population. Methods: The Surveillance Epidemiology and End Results (SEER) registry was queried for patients with HNSCC diagnosed between 2004 and 2007. Overall survival (OS) was estimated by the Kaplan-Meier method and the Cox model was used to compare the survival curves for each AJCC stage. Patients were grouped into three anatomical locations: oral cavity (OC), larynx (L) and OP. Results: There were 26,520 patients meeting eligibility criteria, including 8622 OP, 7332 OC, and 10566 L. The AJCC staging retained its prognostic significance across all stages for patients with HNSCC of the OC and L. Patients with OP cancer, however, had similar 4-year survival for stages I through IVA, whereas stage IVB and IVC had a significantly decrease survival compared to IVA and IVB respectively (Table). Conclusions: The OS for stages III and IVA OP cancer is similar to those with stages I and II, in an effect that may be attributed to the increased frequency of HPV in this population, rendering the tumors more sensitive to chemotherapy and radiation. Therefore, the AJCC stage in OP cancer may be more useful in guiding the therapy than as a prognostic factor. [Table: see text]

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