According to the target of a science center building, some energy-saving technologies and relevant principles phases in architectural planning and design phase, architectural design and construction phase, and so on. With the requirements of energy-saving technologies and an environmental protection technology, some successful experience of Guangdong science center which named as the largest science center building of current China discussed. As a result, the energy-saving science center building design methods came into being, which includes natural ventilation techniques of central yard, optimization technology of enclosed structure, photoelectric curtain wall technology and solar power and so on.