HYDROXYLATED METABOLITES OF TRICYCLIC ANTIDEPRESSANTS: INHIBITION OF AMINE UPTAKE AND OTHER PRE-CLINICAL STUDIES

1979 ◽  
pp. 373-375
Author(s):  
W.Z. Potter ◽  
H.M. Calil ◽  
A. Manian ◽  
F.K. Goodwin
Keyword(s):  
Clinical Studies ◽  
Tricyclic Antidepressants ◽  
Hydroxylated Metabolites ◽  
Amine Uptake

Effects of viloxazine, an antidepressant agent, on biogenic amine uptake mechanisms and related activities

1976 ◽  
Vol 54 (4) ◽  
pp. 494-509 ◽  
Author(s):  
W. Lippmann ◽  
T. A. Pugsley
Keyword(s):  
Tricyclic Antidepressants ◽  
Behavioural Syndrome ◽  
Pharmacological Activities ◽  
Duration Of Action ◽  
Antidepressant Agent ◽  
Amine Uptake ◽  
5 Ht Uptake ◽  
Na Uptake ◽  
Antidepressant Action

The effects of viloxazine, a clinically effective antidepressant, on noradrenaline (NA) and 5-hydroxytryptamine (5-HT) uptake and various related pharmacological activities were determined and compared to those of the tricyclic antidepressants desimipramine, imipramine, and amitriptyline.Viloxazine inhibited [3H]NA uptake in the mouse and rat heart, being maximally about one half as potent as imipramine with a similar onset, but shorter duration of action than imipramine. The drug did not inhibit [3H]NA uptake in rat medulla or hypothalamus in contrast to desimipramine and imipramine, but it did alter [3H]NA metabolites in a similar manner. Viloxazine, like desimipramine, was a weak blocker of mouse brain 5-HT uptake, but differed from desimipramine as it potentiated 5-HT-mediated functions in the mouse and rat, as did imipramine and amitriptyline, the latter drugs being relatively potent blockers of 5-HT uptake.Viloxazine potentiated the L-DOPA behavioural syndrome in the mouse, antagonized reserpine-induced ptosis and hypothermia in the mouse, and inhibited gastric acid secretion in the rat, but was less potent than the tricyclic antidepressants. No appreciable in vivo inhibition of monoamine oxidase (EC 1.4.3.4.) activity in the mouse was exhibited. Like imipramine, the drug potentiated the ocular effects of L-adrenaline in the rabbit. It was similar to imipramine in potency in potentiating the apomorphine-induced gnawing in the mouse. The drug antagonized oxotremorine-induced hypothermia in the mouse but differed from, the tricyclic antidepressants in not exhibiting the anticholinergic effects of blocking the tremors, salivation and lacrimation.Thus, viloxazine exhibits activities related to the biogenic amines both similar to and different from the tricyclics desimipramine, imipramine, and amitriptyline. These actions appear to be of relevance with respect to the antidepressant action of this drug.

Effects of various tricyclic antidepressants on amine uptake

1986 ◽  
Vol 120 (1) ◽  
pp. 63-68 ◽  
Author(s):  
Koichi Ishikawa ◽  
Shinji Shibanoki ◽  
Taizo Kubo ◽  
Shigeo Watabe ◽  
Akira Matsumoto ◽  
...  
Keyword(s):  
Tricyclic Antidepressants ◽  
Amine Uptake

Clinical Studies in Human Strongyloidiasis

1950 ◽  
Vol 16 (4) ◽  
pp. 743-756 ◽  
Author(s):  
Charles A. Jones
Keyword(s):  
Clinical Studies

Exneriana – II – The Scientific Legacy of John E. Exner, Jr. 1Part of this paper was presented at the XIXth International Congress of Rorschach and Projective Methods, July 22–26, 2008, Louvain, Belgium.

2008 ◽  
Vol 29 (2) ◽  
pp. 81-107 ◽  
Author(s):  
Anne Andronikof
Keyword(s):  
Clinical Studies ◽  
Experimental Studies ◽  
Scientific Work ◽  
International Congress ◽  
Response Process ◽  
Scientific Legacy ◽  
Projective Test ◽  
Projective Methods ◽  
Comprehensive Picture ◽  
Complex Mechanisms

Based on an analysis of John Exner’s peer-reviewed published work from 1959 to 2007, plus a brief comment for an editorial in Rorschachiana, the author draws a comprehensive picture of the scientific work of this outstanding personality. The article is divided into three sections: (1) the experimental studies on the Rorschach, (2) the clinical studies using the Rorschach, and (3) Exner’s “testament,” which we draw from the last paper he saw published before his death (Exner, 2001/2002). The experimental studies were aimed at better understanding the nature of the test, in particular the respective roles of perception and projection in the response process. These fundamental studies led to a deeper understanding of the complex mechanisms involved in the Rorschach responses and introduced some hypotheses about the intentions of the author of the test. The latter were subsequently confirmed by the preparatory sketches and documents of Hermann Rorschach, which today can be seen at the H. Rorschach Archives and Museum in Bern (Switzerland). Exner’s research has evidenced the notion that the Rorschach is a perceptive-cognitive-projective test.

Review of Living With Tricyclic Antidepressants.

1997 ◽  
Vol 42 (1) ◽  
pp. 84-84
Author(s):  
Terri Gullickson
Keyword(s):  
Tricyclic Antidepressants
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