scholarly journals Human heart failure is accompanied by altered protein kinase A subunit expression and post-translational state

2013 ◽  
Vol 538 (1) ◽  
pp. 25-33 ◽  
Author(s):  
Young Soo Han ◽  
Jennifer Arroyo ◽  
Ozgur Ogut
Keyword(s):  
Heart Failure ◽  
Protein Kinase ◽  
Protein Kinase A ◽  
Human Heart ◽  
Human Heart Failure ◽  
Altered Protein ◽  
Subunit Expression ◽  
A Subunit ◽  
Kinase A

Characterization of the 5′-flanking region of the gene for the cAMP-inducible protein kinase A subunit, RIIβ, in Sertoli cells

1997 ◽  
Vol 129 (1) ◽  
pp. 101-114 ◽  
Author(s):  
Helle K Knutsen ◽  
Kjetil Taskén ◽  
Winnie Eskild ◽  
JoAnne S Richards ◽  
Richard C Kurten ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Sertoli Cells ◽  
A Subunit ◽  
Flanking Region ◽  
Inducible Protein ◽  
Kinase A

scholarly journals PRKAR1A gene analysis and protein kinase A activity in endometrial tumors

2012 ◽  
Vol 19 (4) ◽  
pp. 457-462 ◽  
Author(s):  
A Tsigginou ◽  
E Bimpaki ◽  
M Nesterova ◽  
A Horvath ◽  
S Boikos ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Regulatory Subunit ◽  
Normal Endometrium ◽  
Protein Levels ◽  
Normal Tissues ◽  
Subunit Expression ◽  
Dependent Protein ◽  
Pka Regulatory Subunit ◽  
Kinase A

PRKAR1A codes for the type 1a regulatory subunit (RIα) of the cAMP-dependent protein kinase A (PKA), an enzyme with an important role in cell cycle regulation and proliferation. PKA dysregulation has been found in various tumors, and PRKAR1A-inactivating mutations have been reported in mostly endocrine neoplasias. In this study, we investigated PKA activity and the PRKAR1A gene in normal and tumor endometrium. Specimens were collected from 31 patients with endometrial cancer. We used as controls 41 samples of endometrium that were collected from surrounding normal tissues or from women undergoing gynecological operations for other reasons. In all samples, we sequenced the PRKAR1A-coding sequence and studied PKA subunit expression; we also determined PKA activity and cAMP binding. PRKAR1A mutations were not found. However, PKA regulatory subunit protein levels, both RIα and those of regulatory subunit type 2b (RIIβ), were lower in tumor samples; cAMP binding was also lower in tumors compared with normal endometrium (P<0.01). Free PKA activity was higher in tumor samples compared with that of control tissue (P<0.01). There are significant PKA enzymatic abnormalities in tumors of the endometrium compared with surrounding normal tissue; as these were not due to PRKAR1A mutations, other mechanisms affecting PKA function ought to be explored.

scholarly journals Defining A-Kinase Anchoring Protein (AKAP) Specificity for the Protein Kinase A Subunit RI (PKA-RI)

ChemBioChem ◽  
2015 ◽  
Vol 17 (8) ◽  
pp. 693-697 ◽  
Author(s):  
Karolin Autenrieth ◽  
N. George Bendzunas ◽  
Daniela Bertinetti ◽  
Friedrich W. Herberg ◽  
Eileen J. Kennedy
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Anchoring Protein ◽  
A Subunit ◽  
Kinase A
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