Metabolic effects of anthelminthic drugs in the larval stage of the cestode Taenia crassiceps, cysticercosis experimental model – A review

Acta Tropica ◽  
2020 ◽  
Vol 206 ◽  
pp. 105448
Author(s):  
Marina C. Vinaud ◽  
Javier Ambrosio
Keyword(s):  
Experimental Model ◽  
Larval Stage ◽  
Metabolic Effects ◽  
Taenia Crassiceps

Hemodynamic and metabolic effects of CO2 pneumoperitoneum in an experimental model of hemorrhagic shock due to retroperitoneal hematoma

1998 ◽  
Vol 12 (5) ◽  
pp. 416-420 ◽  
Author(s):  
M. Steinman ◽  
L. E. da Silva ◽  
I. J. C. Coelho ◽  
R. S. Poggetti ◽  
R. G. Bevilacqua ◽  
...  
Keyword(s):  
Hemorrhagic Shock ◽  
Experimental Model ◽  
Retroperitoneal Hematoma ◽  
Metabolic Effects ◽  
Co2 Pneumoperitoneum

Taenia crassiceps:in vivoandin vitromodels

Parasitology ◽  
2009 ◽  
Vol 137 (3) ◽  
pp. 335-346 ◽  
Author(s):  
KAETHE WILLMS ◽  
RIMMA ZURABIAN
Keyword(s):  
Immune Response ◽  
Experimental Model ◽  
Peritoneal Cavity ◽  
Inbred Mice ◽  
Host Immune Response ◽  
Domestic Animals ◽  
Experimental Results ◽  
Vaccine Research ◽  
Taenia Crassiceps ◽  
Cestode Parasite

SUMMARYTaenia crassicepsis a cestode parasite of wild and domestic animals that rarely affects humans; it has been widely used as an experimental model. The asexual proliferation by budding is a useful attribute ofT. crassicepscysticerci, which allows the various strains to be maintained indefinitely in the peritoneal cavity of inbred mice. Over the last 50 years, experimental results using larval and adult stages ofT. crassicepshave yielded much information on the morphology, infectivity, proliferation dynamics, host immune response, endrocrinological responses and vaccine research, all of which have contributed to our knowledge of cestode biology.

Taenia crassiceps: Experimental model of intraocular cysticercosis

1989 ◽  
Vol 69 (3) ◽  
pp. 324-329 ◽  
Author(s):  
F. Cárdenas ◽  
A. Plancarte ◽  
H. Quiroz ◽  
M.T. Rabiela ◽  
A. Gómez-Leal ◽  
...  
Keyword(s):  
Experimental Model ◽  
Taenia Crassiceps

scholarly journals Experimental encephalitis caused by Taenia crassiceps cysticerci in mice

2012 ◽  
Vol 70 (4) ◽  
pp. 287-292 ◽  
Author(s):  
Hidelberto Matos-Silva ◽  
Bruno Pereira Reciputti ◽  
Élbio Cândido de Paula ◽  
André Luiz Oliveira ◽  
Vânia Beatriz Lopes Moura ◽  
...  
Keyword(s):  
Experimental Model ◽  
Acute Inflammation ◽  
Taenia Crassiceps ◽  
Inflammatory Lesions ◽  
Initial Stage ◽  
Host Parasite Relationship ◽  
Parasite Relationship ◽  
Histopathologic Analysis ◽  
Host Parasite

OBJECTIVES: To present the experimental model of neurocysticercosis (NCC) caused by Taenia crassiceps cysticerci, to describe the inflammatory process, susceptibility, or resistance of BALB/c and C57BL/6 mice to this infection, and to describe the host-parasite relationship. METHODS: The animals were intracranially inoculated with initial stage T. crassiceps cysticerci. They were euthanized at 7, 30, 60, and 90 days after the inoculation. Their encephala were removed for the histopathologic analysis, classification of the parasites, and inflammatory lesions. RESULTS: Experimental NCC was observed on both mice lineages. BALB/c mice presented inflammatory lesions with greater intensity, inducing necrosis on late stage parasites, and with an acute inflammation pattern, while C57BL/6 mice showed greater capability on provoking early necrosis in the cysticerci, which showed a chronic inflammation pattern. CONCLUSIONS: This experimental model induced NCC on mice with characteristic inflammation and lesions. C57BL/6 mice were able to induce precocious necrosis of the parasites presenting inflammatory lesions with lower intensity.

Histopathologic evaluation of experimental murine neurocysticercosis after treatment with albendazole/nitazoxanide combination

Parasitology ◽  
2020 ◽  
Vol 147 (7) ◽  
pp. 822-827
Author(s):  
Guilherme A. Sampaio ◽  
Larissa V. Zago ◽  
Nayana F. de Lima ◽  
Guaraciara de A. Picanço ◽  
Ruy de S. Lino Júnior ◽  
...  
Keyword(s):  
Single Dose ◽  
Experimental Model ◽  
Combination Treatment ◽  
The Other ◽  
Control Groups ◽  
Inflammatory Infiltration ◽  
Taenia Crassiceps ◽  
Brain Infection ◽  
Histopathologic Evaluation ◽  
Foamy Macrophages

AbstractNeurocysticercosis (NCC) is the most common helminthic brain infection related to epilepsy. Only albendazole (ABZ) and praziquantel are used in its treatment. The development of new therapeutics has been encouraged. Taenia crassiceps cysticerci intracranial infection is the experimental model used in NCC studies. This study evaluated the histopathology of the brains of BALB/c mice experimentally infected with T. crassiceps cysticerci after the treatment with the ABZ/nitazoxanide (NTZ) combination. Thirty days after the inoculation the mice received an oral single dose of the ABZ/NTZ combination (40 mg kg−1 each). The control groups were treated with: NaCl 0.9%; ABZ or NTZ. The histopathologic evaluation of the brains was performed 24 h after treatment. The ABZ treatment induced discrete mononuclear inflammatory infiltration, meningitis, gliosis, hyperaemia and hippocampus compression; moderate ependimitis and oedema. The NTZ treatment induced accentuated inflammatory infiltration, foamy macrophages, ependimitis, choroiditis, gliosis and hyperaemia and moderate oedema. The ABZ/NTZ combination treatment induced a significant decrease in the polymorphonuclear inflammatory infiltration, ependimitis, choroiditis, gliosis, hyperaemia and ventriculomegaly in comparison with the other groups. The cysticerci showed destruction of the tegument not observed in other groups. The ABZ/NTZ combination is efficient as the parasite showed signs of destruction and lower damage to the host's tissue.

Ultrastructural Alterations in Sinusoidal Endothelial Fenestrae as a Result of Hypoxia

1976 ◽  
Vol 34 ◽  
pp. 168-169
Author(s):  
Waykin Nopanitaya ◽  
Raeford E. Brown ◽  
Joe W. Grisham ◽  
Johnny L. Carson
Keyword(s):  
Endothelial Cells ◽  
Experimental Model ◽  
Hepatic Lobule ◽  
Ultrastructural Alterations ◽  
Large Type ◽  
Sinusoidal Endothelial Fenestrae ◽  
General Size ◽  
Sem Studies

Mammalian endothelial cells lining hepatic sinusoids have been found to be widely fenestrated. Previous SEM studies (1,2) have noted two general size catagories of fenestrations; large fenestrae were distributed randomly while the small type occurred in groups. These investigations also reported that large fenestrae were more numerous and larger in the endothelial cells at the afferent ends of sinusoids or around the portal areas, whereas small fenestrae were more numerous around the centrilobular portion of the hepatic lobule. It has been further suggested that under some physiologic conditions small fenestrae could fuse and subsequently become the large type, but this is, as yet, unproven.We have used a reproducible experimental model of hypoxia to study the ultrastructural alterations in sinusoidal endothelial fenestrations in order to investigate the origin of occurrence of large fenestrae.

The early development of antenna and antennal sensilla in the noctuid moth, Agrotis segetum (Insecta: Lepidoptera)

1990 ◽  
Vol 48 (3) ◽  
pp. 502-503
Author(s):  
Eric Hallberg ◽  
Lina Hansén
Keyword(s):  
Cell Death ◽  
Stem Cell ◽  
Early Development ◽  
Larval Stage ◽  
Pupal Stage ◽  
Agrotis Segetum ◽  
Antennal Sensilla ◽  
Noctuid Moth ◽  
Standard Procedures

The antennal rudiments in lepidopterous insects are present as disks during the larval stage. The tubular double-walled antennal disk is present beneath the larval antenna, and its inner layer gives rise to the adult antenna during the pupal stage. The sensilla develop from a cluster of cells that are derived from one stem cell, which gives rise to both sensory and enveloping cells. During the morphogenesis of the sensillum these cells undergo major transformations, including cell death. In the moth Agrotis segetum the pupal stage lasts about 14 days (temperature, 25°C). The antennae, clearly seen from the exterior, were dissected and fixed according to standard procedures (3 % glutaraldehyde in 0.15 M cacaodylate buffer, followed by 1 % osmiumtetroxide in the same buffer). Pupae from day 1 to day 8, of both sexes were studied.

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