INFLUENCE OF GAMMA RADIATION ON AMPHOTERICIN B INCORPORATED IN PVP HYDROGEL AS AN ALTERNATIVE TREATMENT FOR CUTANEOUS LEISHMANIOSIS

Leishmania is a vector-induced endemic tropical disease caused by protozoans. The most common cutaneous, mucosal and visceral forms are the cutaneous form. The main drugs in treatment are pentavalent antimony compounds, but their side effects create limitation of use. Local antimony compounds are used primarily in the treatment of cutaneous leishmaniasis. In some cases, alternative treatment modalities are required due to insufficient response to local treatment. Systemic amphotericin B treatment is one of the alternative treatments. In a patient who developed cutaneous Leishmania at 21 months and who did not respond with local meglumine antimoniate therapy, a total of 21 mg/kg dose of systemic amphotericin B was given intermittently and successful results were obtained.

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Effect of ionizing (gamma) and non-ionizing (UV) radiation on the development of Trichogramma euproctidis (Hymenoptera: Trichogrammatidae)

Archives of Biological Sciences ◽

10.2298/abs1201287t ◽

2012 ◽

Vol 64 (1) ◽

pp. 287-295 ◽

Cited By ~ 5

Author(s):

Aydin Tuncbilek ◽

Sumer Ercan ◽

Ulku Canpolat

Keyword(s):

Ultraviolet Radiation ◽

Gamma Radiation ◽

Uv Radiation ◽

Alternative Treatment ◽

Egg Parasitoid ◽

Developmental Cycle ◽

Unexpected Result ◽

Prepupal Stage ◽

Uv C ◽

Different Doses

The potential of using gamma and ultraviolet radiation as an alternative treatment to increase the efficiency of Trichogramma euproctidis (Girault 1911) (Hymenoptera: Trichogrammatidae) was investigated in the laboratory. The developmental and adult stages of T. euproctidis were exposed to gamma radiation of different doses (0-30 Gy) and ultraviolet radiation of 254 nm wavelengths (UV-C) for different durations (0-10 min) to assess their effect on each of the instars and their potential in breaking the developmental cycle of the egg parasitoid. The LD50 values for eggs, prepupae, pupae and adults were 8.1, 10.0, 22.7 and 9.5 Gy for gamma radiation and 9.5, 0.12, 2.0 and 11.9 min for UV radiation, respectively. The pupa and adult stages were more radioresistant to both gamma and UV radiation. The most interesting and unexpected result obtained for the prepupal stage was that UV radiation has a greater effect on prepupal stages than gamma radiation.

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In VitroEvaluation of the Type of Interaction Obtained by the Combination of Terbinafine and Itraconazole, Voriconazole, or Amphotericin B against Dematiaceous Molds

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.01015-10 ◽

2011 ◽

Vol 55 (9) ◽

pp. 4485-4487 ◽

Cited By ~ 10

Author(s):

Fernanda Simas Corrêa Biancalana ◽

Luzia Lyra ◽

Angélica Zaninelli Schreiber

Keyword(s):

Amphotericin B ◽

Alternative Treatment ◽

Concentration Index ◽

Inhibitory Concentration ◽

Drug Combinations ◽

Fractional Inhibitory Concentration ◽

Fractional Inhibitory Concentration Index ◽

Single Drug ◽

Microdilution Method

ABSTRACTIn vitroassociations using the checkerboard microdilution method indicated lower MIC ranges and MIC median values for each drug (terbinafine, itraconazole, voriconazole, and amphotericin B) in association than those obtained for each single drug. Fractional inhibitory concentration index (FIC) results showed 100% synergism in the association of terbinafine with voriconazole, 96.5% in the association of terbinafine with amphotericin B, and 75.9% in the association of terbinafine with itraconazole. Drug combinations may be useful for treatment of dematiaceous mold infections as an alternative treatment to enhance the effectiveness of each drug.

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TREATMENT OF SPOROTRICOSE IN THE WORLD, WITH EMPHASIS IN BRAZIL: WHAT’S NEW?

International Journal of Traditional and Complementary Medicine ◽

10.28933/ijtcm-2021-06-1805 ◽

2021 ◽

pp. 36

Author(s):

◽

Keyword(s):

Amphotericin B ◽

Alternative Treatment ◽

Scientific Literature ◽

Specific Work ◽

Alternative Treatments ◽

Work Requirements ◽

Alternative Medicines ◽

The World

Objective: To evaluate the in vitro and in vivo results of works already published on the use of traditional and alternative medicines in the treatment of sporotrichosis, both in humans and in animals. Methods: The bibliographic research was developed from the analysis of publications found in the scientific literature, with emphasis mainly on Brazil in the period from 2015 to 2020. Updated bibliographies of the medical and veterinary literature were available on MEDLINE, through PubMed, Science direct, Scielo and academic Google, with a total of 28 studies that met the specific work requirements. Results: From the analysis of the reviewed papers, conventional treatments, mainly the use of itraconazole, Amphotericin B and Terbinafine, showed good results in the studies. In addition, the use of alternative treatments, either as the main treatment or support, against sporotrichosis, have shown promise in vitro results, requiring more tests for a possible alternative treatment in the future. Conclusion: The use of alternative treatments is important, since they can be effective against sporotrichosis, becoming a viable means when the animal is resistant to conventional methods.

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A Case of Cutaneous Leishmaniasis Responding to Systemic Liposomal Amphotericin B Treatment

Çocuk Enfeksiyon Dergisi/Journal of Pediatric Infection ◽

10.5578/ced.69928 ◽

2020 ◽

Vol 54 (4) ◽

pp. 247-250

Author(s):

Esra Çakmak Taşkın ◽

Hatice Büşra Kütükçü ◽

Hatice Kübra Konca ◽

Gül Arga ◽

Halil Özdemir ◽

...

Keyword(s):

Side Effects ◽

Cutaneous Leishmaniasis ◽

Amphotericin B ◽

Alternative Treatment ◽

Liposomal Amphotericin ◽

Local Treatment ◽

Treatment Modalities ◽

Pentavalent Antimony ◽

Insufficient Response ◽

Cutaneous Form

Leishmania is a vector-induced endemic tropical disease caused by protozoans. The most common cutaneous, mucosal and visceral forms are the cutaneous form. The main drugs in treatment are pentavalent antimony compounds, but their side effects create limitation of use. Local antimony compounds are used primarily in the treatment of cutaneous leishmaniasis. In some cases, alternative treatment modalities are required due to insufficient response to local treatment. Systemic amphotericin B treatment is one of the alternative treatments. In a patient who developed cutaneous leishmania at 21 months and who did not respond with local meglumine antimoniate therapy, a total of 21 mg / kg dose of systemic amphotericin B was given intermittently and successful results were obtained.

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Effects of sterilization modes on the mechanical strengths of plaster of paris implants

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100156432 ◽

1989 ◽

Vol 47 ◽

pp. 890-891

Author(s):

K. Cowden ◽

B. Giammara ◽

T. Devine ◽

J. Hanker

Keyword(s):

Gamma Radiation ◽

Calcium Sulfate ◽

Significant Loss ◽

Potassium Sulfate ◽

Limiting Factors ◽

Radiation Sterilization ◽

Plaster Of Paris ◽

Hardness Tester ◽

Dry Heat ◽

Calcium Sulfate Hemihydrate

Plaster of Paris (calcium sulfate hemihydrate, CaSO4. ½ H2O) has been used as a biomedical implant material since 1892. One of the primary limiting factors of these implants is their mechanical properties. These materials have low compressive and tensile strengths when compared to normal bone. These are important limiting factors where large biomechanical forces exist. Previous work has suggested that sterilization techniques could affect the implant’s strength. A study of plaster of Paris implant mechanical and physical properties to find optimum sterilization techniques therefore, could lead to a significant increase in their application and promise for future use as hard tissue prosthetic materials.USG Medical Grade Calcium Sulfate Hemihydrate Types A, A-1 and B, were sterilized by dry heat and by gamma radiation. Types A and B were additionally sterilized with and without the setting agent potassium sulfate (K2SO4). The plaster mixtures were then moistened with a minimum amount of water and formed into disks (.339 in. diameter x .053 in. deep) in polyethylene molds with a microspatula. After drying, the disks were fractured with a Stokes Hardness Tester. The compressive strengths of the disks were obtained directly from the hardness tester. Values for the maximum tensile strengths σo were then calculated: where (P = applied compression, D = disk diameter, and t = disk thickness). Plaster disks (types A and B) that contained no setting agent showed a significant loss in strength with either dry heat or gamma radiation sterilization. Those that contained potassium sulfate (K2SO4) did not show a significant loss in strength with either sterilization technique. In all comparisons (with and without K2SO4 and with either dry heat or gamma radiation sterilization) the type B plaster had higher compressive and tensile strengths than that of the type A plaster. The type A-1 plaster however, which is specially modified for accelerated setting, was comparable to that of type B with K2SO4 in both compressive and tensile strength (Table 1).

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