A flexible porous chiral auxetic tracheal stent with ciliated epithelium

Author(s):  
Jiapeng Liu ◽  
Xinhua Yao ◽  
Zhenwei Wang ◽  
Jian Ye ◽  
Congcong Luan ◽  
...  
2006 ◽  
Vol 57 (3) ◽  
pp. 312-317
Author(s):  
Sou Hara ◽  
Shigemichi Iwae ◽  
Toshihumi Hasegawa ◽  
Kouichirou Yonezawa

2017 ◽  
Vol 33 (1) ◽  
pp. 47-52
Author(s):  
Woo joo Nam ◽  
◽  
So Yean Kim ◽  
Tae Hwan Kim ◽  
Sang Hyuk Lee ◽  
...  

2005 ◽  
Vol 114 (4) ◽  
pp. 279-288 ◽  
Author(s):  
Satish Govindaraj ◽  
Elena Fedorova ◽  
Eric M. Genden ◽  
Houtan Chaboki ◽  
Jonathan S. Bromberg ◽  
...  

Prior work has demonstrated that immunosuppressed orthotopic tracheal allografts undergo progressive reepithelialization over a 48-day period with recipient-derived tracheal epithelium. We hypothesized that reepithelialization of tracheal allografts would prevent rejection after withdrawal of immunosuppression. BALB/c murine tracheal grafts were transplanted orthotopically into either syngeneic or allogeneic C57/BL6 recipients. The recipients were either not immunosuppressed, immunosuppressed with cyclosporine A (10 mg/kg per day) continuously, or immunosuppressed for 48 days and then withdrawn from immunosuppression. The grafts were assessed for acute and chronic rejection 10 days and 50 days after immunosuppression withdrawal. The immunosuppressed allograft recipients maintained a ciliated epithelium acutely and chronically after immunosuppression withdrawal. Ten days after immunosuppression withdrawal, there was a mild cellular infiltrate, which resolved 50 days after withdrawal. Electron microscopy, lymphocyte subpopulation assays, and lamina propria analysis demonstrated that immunosuppression withdrawal did not result in tracheal allograft rejection. In vitro and in vivo assessments did not demonstrate evidence of systemic or local immune tolerance. We conclude that reepithelialization of orthotopic tracheal allografts with recipient-derived mucosa prevents rejection of allograft segments. Tracheal transplantation may require only transient immunosuppression, which can be withdrawn after tracheal reepithelialization.


2014 ◽  
Vol 39 (3) ◽  
pp. 499-505 ◽  
Author(s):  
Teruya Ohba ◽  
Jiegou Xu ◽  
David B. Alexander ◽  
Akane Yamada ◽  
Jun Kanno ◽  
...  

1982 ◽  
Vol 63 (4) ◽  
pp. 26-29
Author(s):  
V. A. Anokhin

The activation of the kinin system of the blood in diseases of the respiratory system leads to an increase in the inflammatory response in the respiratory tract, causes bronchospasm to a large extent, and has an inhibitory effect on the function of the ciliated epithelium. There are no unequivocal judgments about the therapeutic effect of prednisolone in obstructive bronchitis and bronchiolitis in the literature. There is a negative answer to this question. At the same time, the beneficial effect of corticosteroids on pulmonary mechanics in bronchiolitis was noted.


2018 ◽  
Vol 1 (5) ◽  
pp. 1328-1336 ◽  
Author(s):  
Zhu Jin ◽  
Zhaoyang Chen ◽  
Keqin Wu ◽  
Yuanyuan Shen ◽  
Shengrong Guo

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