Cardiac remodelling in secondary tricuspid regurgitation: Should we look beyond the tricuspid annulus diameter?

2021 ◽  
Author(s):  
Anne Guérin ◽  
Elsa Vabret ◽  
Julien Dreyfus ◽  
Yoan Lavie-Badie ◽  
Catherine Sportouch ◽  
...  
Keyword(s):  
Tricuspid Regurgitation ◽  
Cardiac Remodelling ◽  
Tricuspid Annulus ◽  
Annulus Diameter

Is Isolated tricuspid regurgitation different from functional tricuspid regurgitation?

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
J.M Vieitez Florez ◽  
J.M Monteagudo ◽  
P Mahia ◽  
I Marco ◽  
T Gonzalez ◽  
...  
Keyword(s):  
Prospective Study ◽  
Tricuspid Regurgitation ◽  
Functional Class ◽  
Tricuspid Annulus ◽  
Large Prospective Study ◽  
Functional Tricuspid Regurgitation ◽  
Echocardiographic Study ◽  
Rv Function ◽  
Worse Prognosis ◽  
Annulus Diameter

Abstract Introduction Isolated tricuspid regurgitation (TR) prevalence is increasing in the last decades. Its presence is associated with a worse prognosis when EROA is >40 mm2. Because of high surgery risk and increasing incidence, isolated TR is a challenge in modern cardiology. Purpose To evaluate the prevalence and characteristics of isolated TR compared to other TR aetiologies in a large cohort of patients. Methods Prospective study where consecutive patients undergoing an echocardiographic study within a three-month period were included. All studies with at least moderate TR were selected. Isolated TR was defined as TR with no likely pulmonary hypertension (>50 mmHg), no overt TR cause (no intrinsic tricuspid disease, LVEF ≥50%, no pacemaker/defibrillator wire across the tricuspid, no other significant valve disease, no disease that may cause TR, no congenital or pericardial heart disease); and no previous valve surgery. Patients with isolated TR and other aetiologies were compared. Results 2121 patients with at least moderate TR were included. Isolated TR was found in 398 patients (18.8%). Basal characteristics are shown in table 1. Patients with isolated TR did not have a higher prevalence of AF (47.5% vs. 48.6% p=0.362). Isolated TR was less severe (20.5% vs. 32.1% of patients with severe TR; p<0.001) and less symptomatic (NYHA ≥ II in 27.8% of patients vs. 69.3%; p<0.001). After selecting patients with at least severe TR, patients with isolated TR were also less symptomatic (NYHA≥II in 47.8% of patients vs. 70.7%; p<0.001) and they had better RV function (TAPSE <17 mm in 13.4% vs. 35.6%; p=0.001). We found that patients with isolated severe TR had a larger tricuspid annulus diameter (25.4±0.8 mm/m2 vs. 24.0±0.3 mm/m2; p=0.047). Conclusions In this large prospective study, isolated TR is present in 18.8% of significant TR. Isolated TR was less severe, was associated with less RV dilatation (but with larger tricuspid annulus diameter) and patients had a better functional class compared to other TR aetiologies. Differeces in NYHA and RV function Funding Acknowledgement Type of funding source: None

5940Right ventricular reverse remodeling occurs early after transcatheter tricuspid valve repair for isolated severe tricuspid regurgitation and is associated with better outcome

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
M Orban ◽  
L Stolz ◽  
D Braun ◽  
T Stocker ◽  
K Stark ◽  
...  
Keyword(s):  
Heart Failure ◽  
Clinical Outcome ◽  
Tricuspid Valve ◽  
Tricuspid Regurgitation ◽  
Significant Trend ◽  
Tricuspid Valve Repair ◽  
Tricuspid Annulus ◽  
Valve Repair ◽  
Severe Tricuspid Regurgitation

Abstract Background Transcatheter edge-to-edge tricuspid valve repair (TTVR) is a novel treatment option in patients with severe tricuspid regurgitation (TR), right-sided heart failure and prohibitive surgical risk. Purpose We investigated whether RVRR can occur early after TTVR in patients with isolated TR and its potential association with clinical outcome. Method We measured right ventricular parameters by transthoracic echocardiography (TTE) at baseline (BL) in 44 consecutive patients undergoing TTVR for isolated severe TR. We obtained follow-up (FU) TTEs after 1 month. Results At BL, we observed dilated RVs with an RV end-diastolic area (RVEDA) of 28.0±8.3cm2, RV mid diameter of 40.7±7.3mm and tricuspid annulus of 47.5±8.1mm. The majority of patients (63%) showed RV systolic dysfunction with either a tricuspid annular plane excursion (TAPSE) <17mm or fractional area change (FAC) <35%. In 40 Patients (90%), a periprocedural TR reduction by at least 1 degree was achieved (p<0.01). During further clinical FU (272±183 days), 21 patients died (of whom 14 had prior hospitalizations for heart failure before death), 8 patients had hospitalizations for heart failure, 1 patient underwent heart transplantation and 1 patient was lost to clinical FU. We acquired a short-term echocardiographic follow-up (Echo-FU) after 30 days in 36 patients (82%). TR reduction was stable after 1 month with a TR grade ≤2+ in 26 of 36 patients (72%, p<0.01 vs BL). We detected RVRR in the majority of patients with 1-month Echo-FU: RVEDA decreased from 28.8±8.2 to 26.3±7.4cm2 (p<0.01), RV mid diameter from 41.2±7.3 to 38.5±7.7mm (p<0.01) and tricuspid annulus from 48.3±8.3 to 42.8±6.6mm (Figure, p<0.01). We observed a non-significant trend towards reduction of TAPSE (17.5mm to 16.1 mm, p=0.12) and FAC (37.8% to 35.5%, p=0.17), which could represent a normalization of systolic function of a previously hyperactive RV. Next, we evaluated whether RVRR is potentially associated with clinical outcome. We stratified patients into two groups with more or less than median change in RVEDA, RV mid diameter and TV annulus. Fewer combined clinical events (time to death or repeat intervention or first hospitalization for heart failure) were observed in patients with pronounced decrease of RV mid diameter (p=0.03) and TV annulus (Figure, p=0.02) at FU. A decrease of RVEDA showed a non-significant trend towards better outcome (p=0.06). Figure 1 Conclusions Our report demonstrates that RVRR occurs already 1 month after TTVR for isolated TR and is associated with less clinical endpoints.

scholarly journals Research on The Frame of Reference with The Downward Displacement of The Posterior Leaflet and Anterior Leaflet of Tricuspid Valve in Children by Ultrasound

2021 ◽  
Author(s):  
Jun-jian Yu ◽  
Kang Liu ◽  
Rong-cheng Tian ◽  
Xuehong Zhong ◽  
Bei Li
Keyword(s):  
Tricuspid Valve ◽  
Tricuspid Regurgitation ◽  
Color Doppler ◽  
Frame Of Reference ◽  
Posterior Leaflet ◽  
Anterior Leaflet ◽  
Tricuspid Annulus ◽  
Color Doppler Flow Imaging ◽  
Chamber View ◽  
Downward Displacement

To investigate the frame of reference with the downward displacement of the posterior leaflet and anterior leaflet of tricuspid valve in children by ultrasound.The downward degree of anterior and posterior tricuspid valve was evaluated with tricuspid annulus and coronary sinus as reference structures under ultrasound, and the position of tricuspid regurgitation orifice was shown by color ultrasound. Color Doppler flow imaging showed that the position of tricuspid regurgitation orifice moved down obviously in all 42 children. One case showed 2.2cm from the root of the anterior valve to the tricuspid annulus in the two-chamber and four-chamber view of the apical right heart. Color Doppler can show that the position and direction of tricuspid regurgitation orifice are obviously deviated to the anterolateral side. The obvious deviation of the tricuspid regurgitation orifice to the anterolateral direction may be an ultrasonic sign for diagnosing the downward displacement of the anterior tricuspid valve in children.

scholarly journals Characteristics of idiopathic tricuspid regurgitation

2021 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
LWY Li ◽  
MS Huang ◽  
WH Lee ◽  
WC Tsai
Keyword(s):  
Pulmonary Hypertension ◽  
Heart Disease ◽  
Tricuspid Regurgitation ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Systemic Approach ◽  
Left Heart ◽  
Tricuspid Annulus ◽  
Left Heart Disease ◽  
Rv Function

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Ministry of Science and Technology, Executive Yuan, Taiwan Background Tricuspid regurgitation (TR) were traditionally classified as primary and secondary TR. Recently a new category of TR was developed and named as idiopathic TR. However, diagnosis and characteristics of idiopathic TR were not consisted. We tried to identify idiopathic TR by a new systemic approach and studied its characteristics. Methods 207 consecutive patients (mean age 71.2 ± 14.7 years, 40.6% male) identified as significant TR (moderate and severe) by echocardiography were recruited. We classified TR by a new systemic approach. The classification process started from identified primary TR, then pacemaker related TR, left heart disease related TR, congenital heart related TR, right ventricular (RV) myopathy, pulmonary hypertension and, finally idiopathic TR step by step. Results There were 29 (14%) primary TR, 18 (8.7%) pacemaker related, 81 (39.1 %) left heart diseases, 6 (2.9%) congenital heart diseases, 3 (1.4%) RV myopathy, 27 (13%) pulmonary hypertension, and 43 (20.8%) idiopathic TR. Mean age of idiopathic TR was 72.9 ± 11.4 years and 39.5% was male which were not different from other groups. Atrial fibrillation was presented highest in patients with pacemaker related TR (77.8%) and left heart disease (55.6%), lowest in primary TR (24.1%) and pulmonary HT (25.9%), and modest in idiopathic TR (44.2%). Among the echocardiographic characteristics of right heart measurements, idiopathic TR had lowest TR maximal velocity (3.0 ± 0.3 m/s), pulmonary (41.2 ± 8.7 mmHg) and right atrium pressure (5.3 ± 0.3 mmHg; all p &lt;0.001). Idiopathic TR had smallest RV wall thickness (4.5 ± 1.4 mm; p = 0.008), tricuspid annulus diameter (3.2 ± 0.7 cm; p = 0.001), and right atrial area (18.9 ± 8.4 cm2; p &lt;0.001). RV function represented as tricuspid annulus velocity S’ (12.8 ± 3.3 cm/s; p = 0.011) and RV fractional area change FAC (42.6 ± 16.0 %; p &lt;0.001) were best in idiopathic TR. RV dysfunction (FAC &lt; 35%) was lowest (14%) in idiopathic TR. Conclusions Idiopathic TR had better RV function then other types of TR. Idiopathic TR can be regarded as a unique disease category in studying TR.

scholarly journals Echocardiographic Follow-Up of Right Ventricular Function After Tetralogy of Fallot Operation

2020 ◽  
pp. 1-8
Author(s):  
Canan Ayabakan ◽  
Canan Ayabakan ◽  
Kürşad Tokel ◽  
Özlem Sarısoy
Keyword(s):  
Right Ventricular ◽  
Pulmonary Valve Replacement ◽  
Volume Index ◽  
Z Score ◽  
Tricuspid Annulus ◽  
Area Index ◽  
Asymptomatic Patients ◽  
Inlet Length ◽  
Annulus Diameter

Aim: Although limited in assessing right ventricular (RV) function, echocardiography is widely used after correction for tetralogy of Fallot (TOF). The change in echocardiographic measurements of RV in asymptomatic patients after TOF repair over a long follow-up time is not explored yet. The variation in simple echocardiographic measurements during follow-up of our TOF patients are presented. The predictive value of those parameters in determining a future pulmonary valve replacement is sought. Method: Asymptomatic patients surviving the first year after correction for simple TOF from February 2007 to December 2019 at Başkent University, Istanbul Hospital are enrolled. Patients are followed annually with echocardiography including: RV area, volume, length, RV outflow tract (RVOT) diameter and gradient, tricuspid annulus diameter, tricuspid lateral annular tissue velocities, tricuspid annular plane systolic excursion, TEI index RV ejection fraction (EF) measurements. The change in the consecutive echocardiographic measurements during follow-up is analysed. Patients are evaluated with a cardiac magnetic resonance (CMR) imaging when deemed necessary and compared with echocardiographic measurements. Results: A total of 66 patients (54.5% males) are operated at age 14.4±9.3 months (78.8% with transannular patch). Twelve patients had pulmonary valve replacement (PVR) operation at an age 10.1±3.1 years. During follow-up of 7.2±4.3 years, tricuspid annulus diameter, RV area, RV inlet length, RV volume, RV volume index significantly increased (p=0.001 for all), whereas RV inlet length index, TEI and TEI z score decreased (p<0.0001 for all). When means are compared, tricuspid annulus (28.8mm vs 25.0mm; p=0.013), RV volume (72.2ml vs 52.2ml; p=0.042), RV inlet length index (77.9mm/m2 vs 60.2mm/m2 ; p=0.013), RVOT diameter (28.7 vs 23.0; p=0.007) are increased. RV EF is decreased (51.3% vs 60.5%; p=0.011) in those requiring PVR. Those with higher RV area index, RV volume index, tricuspid annulus diameter and tricuspid annular z score in their first echocardiography after the TOF repair, are more likely to have a PVR operation later on (p<0.05 for all). RV volume index ≥39ml/m2 predicts a PVR within 7 years with 100% sensitivity and 74% specificity. Tricuspid annular z score less than -0.43 seems to eliminate the possibility of having a PVR within 7 years with a sensitivity of 44% and specificity of 100%. Conclusion: Observing the sequential change in echocardiographic parameters like RV volume index, RV area index, tricuspid annulus z score is reliable in determining right ventricular function and can limit the costly CMR applications. Cut off values of RV volume index >39ml/m2 and tricuspid annulus z score ≥ - 0.43 after the initial TOF repair may determine patients with higher possibility of having early PVR and indicate a closer follow-up.

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